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Busch RM, Najm I, Hermann BP, et al. Genetics of cognition in epilepsy. Epilepsy Behav. 2014;41:297-306doi: 10.1016/j.yebeh.2014.05.026.
Busch, R. M., Najm, I., Hermann, B. P., & Eng, C. (2014). Genetics of cognition in epilepsy. Epilepsy & behavior : E&B, 41297-306. https://doi.org/10.1016/j.yebeh.2014.05.026
Busch, Robyn M, et al. "Genetics of cognition in epilepsy." Epilepsy & behavior : E&B vol. 41 (2014): 297-306. doi: https://doi.org/10.1016/j.yebeh.2014.05.026
Busch RM, Najm I, Hermann BP, Eng C. Genetics of cognition in epilepsy. Epilepsy Behav. 2014 Dec;41:297-306. doi: 10.1016/j.yebeh.2014.05.026. Epub 2014 Jun 25. PMID: 24973143; PMCID: PMC4268334.
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Epilepsy Behav. 2014 Dec;41:297-306. doi: 10.1016/j.yebeh.2014.05.026. Epub 2014 Jun 25.

Genetics of cognition in epilepsy.

Epilepsy & behavior : E&B

Robyn M Busch, Imad Najm, Bruce P Hermann, Charis Eng

Affiliations

  1. Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Psychiatry & Psychology, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: [email protected].
  2. Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
  3. Charles Matthew Neuropsychology Section, Department of Neurology, University of Wisconsin, Madison, WI, USA.
  4. Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.

PMID: 24973143 PMCID: PMC4268334 DOI: 10.1016/j.yebeh.2014.05.026

Abstract

With the completion of the Human Genome Project and the advent of more advanced sequencing platforms capable of high throughput genotyping at reduced cost, research on the genetics/genomics of cognition has expanded rapidly over the past several decades. This has been facilitated even further by global consortia including HapMap, 1000 Genomes Project, ENCODE, and others, which have made information regarding genetic variation and genomic functional elements readily available to all researchers. Thus, the goal of this Targeted Review is not to provide an exhaustive review of the existing literature on the role of genetic factors in cognition. Rather, we will highlight some of the most consistent findings in this field, review the research in epilepsy to date, and provide a background within which to set forth unique opportunities epilepsy may provide to further elucidate the role of genetics in cognition.

Copyright © 2014 Elsevier Inc. All rights reserved.

Keywords: Cognition; Epilepsy; Epilepsy surgery; Genetics; Genomics; Neuropsychology

References

  1. Cereb Cortex. 2007 Feb;17(2):261-71 - PubMed
  2. Nature. 2007 May 10;447(7141):178-82 - PubMed
  3. Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):403-6 - PubMed
  4. Adv Tech Stand Neurosurg. 2012;39:131-63 - PubMed
  5. J Neurosci. 1997 Jan 15;17(2):516-29 - PubMed
  6. Curr Top Behav Neurosci. 2012;12:345-60 - PubMed
  7. Neuropsychologia. 2010 Jan;48(2):402-8 - PubMed
  8. Am J Med Genet A. 2009 Mar;149A(3):387-95 - PubMed
  9. Neurology. 2007 Feb 6;68(6):409-14 - PubMed
  10. Nat Neurosci. 2003 Nov;6(11):1141-2 - PubMed
  11. Nature. 2012 Nov 1;491(7422):56-65 - PubMed
  12. Cold Spring Harb Perspect Biol. 2014 Jan 01;6(1): - PubMed
  13. Nature. 2010 Oct 28;467(7319):1061-73 - PubMed
  14. Eur J Hum Genet. 2006 Jun;14(6):701-13 - PubMed
  15. Nature. 2007 Jun 14;447(7146):799-816 - PubMed
  16. Science. 2006 Oct 20;314(5798):475-8 - PubMed
  17. PLoS Med. 2005 Aug;2(8):e124 - PubMed
  18. Neurologist. 2012 Nov;18(6):343-9 - PubMed
  19. Psychol Med. 2009 Nov;39(11):1831-9 - PubMed
  20. Annu Rev Genet. 2011;45:81-104 - PubMed
  21. Brain Dev. 2014 Sep;36(8):711-5 - PubMed
  22. JAMA Psychiatry. 2013 Mar;70(3):311-8 - PubMed
  23. Psychol Med. 2007 Feb;37(2):163-80 - PubMed
  24. Nat Rev Genet. 2012 Jul 10;13(8):537-51 - PubMed
  25. Epilepsy Behav. 2012 Mar;23(3):177-86 - PubMed
  26. Eur J Hum Genet. 2012 Mar;20(3):341-7 - PubMed
  27. Proc Natl Acad Sci U S A. 1986 Feb;83(4):1125-9 - PubMed
  28. Brain. 2008 Apr;131(Pt 4):918-27 - PubMed
  29. Epilepsy Behav. 2010 Apr;17(4):531-5 - PubMed
  30. Psychol Med. 2003 Feb;33(2):335-44 - PubMed
  31. Trends Cogn Sci. 2011 Sep;15(9):381-7 - PubMed
  32. Neurology. 2013 Sep 10;81(11):992-8 - PubMed
  33. Int J Neuropsychopharmacol. 2008 Dec;11(8):1163-7 - PubMed
  34. Epilepsy Behav. 2013 Feb;26(2):165-9 - PubMed
  35. Behav Genet. 2009 Mar;39(2):133-44 - PubMed
  36. Nat Rev Genet. 2013 May;14(5):347-59 - PubMed
  37. J Gerontol A Biol Sci Med Sci. 2012 Jun;67(7):741-6 - PubMed
  38. Front Hum Neurosci. 2008 Sep 23;2:11 - PubMed
  39. Behav Genet. 2004 Sep;34(5):533-9 - PubMed
  40. Hum Mol Genet. 2006 Apr 1;15(7):1195-207 - PubMed
  41. Mol Psychiatry. 2011 Oct;16(10):996-1005 - PubMed
  42. Science. 1993 Aug 13;261(5123):921-3 - PubMed
  43. Annu Rev Genomics Hum Genet. 2011;12:121-44 - PubMed
  44. Psychol Aging. 2004 Dec;19(4):592-600 - PubMed
  45. Neurobiol Aging. 2006 Jan;27(1):150-4 - PubMed
  46. Brain Imaging Behav. 2014 Jun;8(2):153-82 - PubMed
  47. JAMA. 2002 May 8;287(18):2335-8 - PubMed
  48. Hum Mol Genet. 2007 Jun 15;16(12):1469-77 - PubMed
  49. Epilepsy Behav. 2013 Mar;26(3):343-51 - PubMed
  50. Neuroreport. 2005 May 31;16(8):839-42 - PubMed
  51. Neuroscience. 2009 Nov 24;164(1):88-107 - PubMed
  52. Nature. 2005 Oct 27;437(7063):1299-320 - PubMed
  53. Biol Psychiatry. 2009 Apr 15;65(8):671-9 - PubMed
  54. Epilepsia. 2013 May;54 Suppl 2:41-7 - PubMed
  55. Epilepsia. 2011 Apr;52 Suppl 2:39-43 - PubMed
  56. Behav Genet. 2004 Jan;34(1):75-84 - PubMed
  57. Nat Genet. 2008 Jun;40(6):776-81 - PubMed
  58. Nat Genet. 2009 May;41(5):535-43 - PubMed
  59. Int J Dev Neurosci. 2013 Nov;31(7):667-78 - PubMed
  60. J Child Psychol Psychiatry. 2013 Jan;54(1):3-16 - PubMed
  61. Neuropsychol Rev. 2007 Dec;17(4):427-44 - PubMed
  62. Genes Brain Behav. 2006 Jun;5(4):311-28 - PubMed
  63. Neurology. 2007 Jan 2;68(1):62-4 - PubMed
  64. Epilepsia. 2005 Jan;46(1):110-7 - PubMed
  65. Science. 1994 May 6;264(5160):850-2 - PubMed
  66. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4270-4 - PubMed
  67. Am J Med Genet. 1999 Dec 15;88(6):642-6 - PubMed
  68. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12604-9 - PubMed
  69. Eur J Hum Genet. 2012 May;20(5):510-5 - PubMed
  70. Science. 2010 May 7;328(5979):753-6 - PubMed
  71. Epilepsia. 2011 Apr;52 Suppl 2:24-9 - PubMed
  72. Brain Dev. 2012 Jun;34(6):459-68 - PubMed
  73. Ann Neurol. 2014 Feb;75(2):324-6 - PubMed
  74. Ann Hum Genet. 2012 Jul;76(4):277-82 - PubMed
  75. Epilepsy Behav. 2006 May;8(3):635-42 - PubMed
  76. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6917-22 - PubMed
  77. Brain Dev. 2009 Feb;31(2):95-103 - PubMed
  78. Neurosci Lett. 1992 Feb 3;135(2):235-8 - PubMed
  79. Nat Rev Genet. 2008 May;9(5):341-55 - PubMed
  80. Am J Med Genet B Neuropsychiatr Genet. 2012 Dec;159B(8):958-69 - PubMed
  81. J Alzheimers Dis. 2011;23(3):433-42 - PubMed
  82. J Neurosci. 2004 Nov 10;24(45):10099-102 - PubMed
  83. Genes Brain Behav. 2011 Jun;10(4):410-7 - PubMed
  84. Behav Genet. 1995 Sep;25(5):421-31 - PubMed
  85. Nature. 1994 Nov 3;372(6501):92-4 - PubMed
  86. Behav Genet. 2010 Jan;40(1):22-30 - PubMed
  87. Genet Epidemiol. 2002 Feb;22(2):146-55 - PubMed
  88. Am Psychol. 1989 Oct;44(10):1285-92 - PubMed
  89. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1977-81 - PubMed
  90. Epilepsia. 2013 Jul;54(7):1282-7 - PubMed
  91. Nat Genet. 1996 Sep;14(1):55-61 - PubMed
  92. J Neurosci. 2003 Jul 30;23(17):6690-4 - PubMed
  93. Epilepsia. 2009 May;50 Suppl 5:20-3 - PubMed
  94. Nat Genet. 2013 Sep;45(9):1073-6 - PubMed
  95. Am J Psychiatry. 2003 Apr;160(4):636-45 - PubMed
  96. Neuron. 2011 Jun 9;70(5):813-29 - PubMed
  97. Annu Rev Neurosci. 2001;24:677-736 - PubMed
  98. N Engl J Med. 2006 Sep 28;355(13):1345-56 - PubMed
  99. Neuropsychopharmacology. 2012 Jan;37(1):247-60 - PubMed
  100. Psychol Aging. 1995 Sep;10(3):437-46 - PubMed
  101. Mol Psychiatry. 2013 Feb;18(2):255-63 - PubMed
  102. Curr Psychiatry Rep. 2012 Oct;14(5):579-89 - PubMed
  103. Annu Rev Pharmacol Toxicol. 2013;53:311-30 - PubMed
  104. Science. 2004 Oct 22;306(5696):636-40 - PubMed
  105. Neurology. 1993 Aug;43(8):1467-72 - PubMed
  106. Nature. 2003 Dec 18;426(6968):789-96 - PubMed
  107. Mol Psychiatry. 2010 Nov;15(11):1112-20 - PubMed
  108. J Biol Chem. 1995 Nov 10;270(45):27063-71 - PubMed
  109. Psychiatry Res. 2007 Jul 15;155(2):173-7 - PubMed
  110. J Neural Transm (Vienna). 2009 Jul;116(7):897-903 - PubMed
  111. Neurology. 2011 Jul 26;77(4):380-3 - PubMed
  112. Arch Dis Child. 2004 Jun;89(6):530-3 - PubMed
  113. Curr Top Behav Neurosci. 2012;12:579-613 - PubMed
  114. Biol Psychol. 2008 Oct;79(2):239-42 - PubMed
  115. J Gerontol B Psychol Sci Soc Sci. 1999 May;54(3):P173-9 - PubMed
  116. Epilepsia. 2012 Apr;53(4):705-11 - PubMed
  117. Neuropsychology. 2011 Jul;25(4):488-98 - PubMed
  118. Trends Cogn Sci. 2004 Jul;8(7):325-35 - PubMed

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