Display options
Cite
Afolayan AJ, Wintola OA. Dietary supplements in the management of hypertension and diabetes - a review. Afr J Tradit Complement Altern Med. 2014;11(3):248-58doi: 10.4314/ajtcam.v11i3.35.
Afolayan, A. J., & Wintola, O. A. (2014). Dietary supplements in the management of hypertension and diabetes - a review. African journal of traditional, complementary, and alternative medicines : AJTCAM, 11(3), 248-58. https://doi.org/10.4314/ajtcam.v11i3.35
Afolayan, Anthony Jide, and Wintola, Olubunmi Abosede. "Dietary supplements in the management of hypertension and diabetes - a review." African journal of traditional, complementary, and alternative medicines : AJTCAM vol. 11,3 (2014): 248-58. doi: https://doi.org/10.4314/ajtcam.v11i3.35
Afolayan AJ, Wintola OA. Dietary supplements in the management of hypertension and diabetes - a review. Afr J Tradit Complement Altern Med. 2014 Apr 03;11(3):248-58. doi: 10.4314/ajtcam.v11i3.35. eCollection 2014. PMID: 25371590; PMCID: PMC4202446.
Copy Download .nbib Format: NLM
Share it on

Afr J Tradit Complement Altern Med. 2014 Apr 03;11(3):248-58. doi: 10.4314/ajtcam.v11i3.35. eCollection 2014.

Dietary supplements in the management of hypertension and diabetes - a review.

African journal of traditional, complementary, and alternative medicines : AJTCAM

Anthony Jide Afolayan, Olubunmi Abosede Wintola

Affiliations

  1. Medicinal Plant and Economic Development Research Centre, Department of Botany, University of Fort Hare, Alice 5700, South Africa.

PMID: 25371590 PMCID: PMC4202446 DOI: 10.4314/ajtcam.v11i3.35

Abstract

BACKGROUND: The use of alternative therapies like herbs and dietary supplements is very common among hypertensive and diabetic patients all over the globe. Hypertension is a silent disease that causes increase in cardiovascular, cerebrovascular, renal morbidity and mortality whereas diabetic complications cause heart attack, stroke, blindness and kidney disease. These are serious and chronic metabolic disorders that have a significant impact on the health, quality of life, and life expectancy of patients, as well as on the health care systems. Orthodox drugs used for the treatment of hypertension and diabetes produce side effects such as headache, nausea, vomiting, stomach pain, constipation, diarrhea, weakness, fatigue and erectile dysfunction. The need for considering alternate therapies in the form of dietary supplements known to promote good health, having little or no side effects therefore arises.

MATERIALS AND METHODS: This review was carried out using comprehensive and systematic literature reports on the concurrent use of dietary supplements in the management of diabetes and hypertension. Empirical searches were conducted using Google scholar (http://scholar.google.com), and Science Direct (http://www.sciencedirect.com). In addition to these databases, the University database was also used. Searches were also undertaken using keyword combinations such as dietary supplements and the names of the diseases in question.

RESULT AND DISCUSSION: This review chronicled the therapeutic values of vitamins, minerals, amino acids, fruits, vegetables, herbs and other botanicals used as dietary supplements. Results show that these supplements provided better and safe substitutes to toxic and expensive conventional drugs. Generally dietary supplements are free from major side effects, readily available and affordable. It is envisaged that the use of dietary supplement will promote good health and improve the status of hypertensive and diabetic patients.

CONCLUSION: Medical doctors are therefore encouraged to incorporate dietary supplements into the regimen employed for hypertension and diabetes management.

Keywords: Blood pressure; blood glucose; botanicals; minerals; vitamins

References

  1. Ethn Dis. 2001 Winter;11(1):11-8 - PubMed
  2. Endocr Metab Immune Disord Drug Targets. 2011 Sep 1;11(3):232-46 - PubMed
  3. J Biol Chem. 2007 Oct 12;282(41):30143-9 - PubMed
  4. Hypertension. 1994 Mar;23(3):308-12 - PubMed
  5. Pharmacogn Rev. 2011 Jan;5(9):30-40 - PubMed
  6. Atherosclerosis. 2001 Feb 1;154(2):475-83 - PubMed
  7. Am J Physiol Endocrinol Metab. 2007 May;292(5):E1378-87 - PubMed
  8. Circulation. 2001 Nov 27;104(22):2746-53 - PubMed
  9. Ann Emerg Med. 2000 Mar;35(3):226-8 - PubMed
  10. J Clin Endocrinol Metab. 1995 Nov;80(11):3311-20 - PubMed
  11. Diabetes Care. 2004 May;27(5):1047-53 - PubMed
  12. Cochrane Database Syst Rev. 2008 Jan 23;(1):CD003205 - PubMed
  13. Diabetes Care. 2007 Aug;30(8):2154-63 - PubMed
  14. Med Hypotheses. 1999 May;52(5):401-6 - PubMed
  15. J Clin Invest. 1995 Jun;95(6):2501-9 - PubMed
  16. J Epidemiol Community Health. 2004 Jun;58(6):468-75 - PubMed
  17. Prostaglandins Leukot Essent Fatty Acids. 1999 Aug;61(2):83-7 - PubMed
  18. Diabetologia. 2007 Aug;50(8):1593-602 - PubMed
  19. Circulation. 1998 Aug 11;98(6):613-7 - PubMed
  20. Nutr J. 2002 Nov 19;1:4 - PubMed
  21. Arch Intern Med. 1998 Nov 9;158(20):2192-9 - PubMed
  22. J Pediatr Endocrinol Metab. 2000 Nov-Dec;13(9):1621-7 - PubMed
  23. JAMA. 2002 Jun 26;287(24):3223-9 - PubMed
  24. J Hum Hypertens. 2000 Oct-Nov;14(10-11):749-63 - PubMed
  25. J Biol Chem. 2007 May 4;282(18):13736-45 - PubMed
  26. BMJ. 2006 Apr 1;332(7544):752-60 - PubMed
  27. Circulation. 2002 Apr 23;105(16):1897-903 - PubMed
  28. Pharmacol Ther. 2006 Aug;111(2):434-75 - PubMed
  29. Eur J Clin Nutr. 2002 Nov;56(11):1137-42 - PubMed
  30. Lancet. 2005 Jan 15-21;365(9455):217-23 - PubMed
  31. Metabolism. 2007 Oct;56(10):1340-4 - PubMed
  32. J Hum Hypertens. 1997 Jun;11(6):343-50 - PubMed
  33. Diabetes Res Clin Pract. 2001 May;52(2):77-84 - PubMed
  34. Lipids. 2011 May;46(5):417-23 - PubMed
  35. Am Fam Physician. 2005 Sep 15;72(6):1065-70 - PubMed
  36. Circulation. 2001 Mar 27;103(12):1618-23 - PubMed
  37. Diabetes. 1994 Jul;43(7):857-61 - PubMed
  38. Am J Clin Nutr. 2003 Apr;77(4 Suppl):1001S-1007S - PubMed
  39. Am J Clin Nutr. 1998 May;67(5 Suppl):1035S-1040S - PubMed
  40. Diabetes Care. 2002 Feb;25(2):324-9 - PubMed
  41. N Engl J Med. 1983 Aug 25;309(8):445-8 - PubMed
  42. Am J Clin Nutr. 2001 Dec;74(6):714-22 - PubMed
  43. Ann N Y Acad Sci. 1990;585:321-30 - PubMed
  44. Diabetes Care. 1999 Feb;22(2):280-7 - PubMed
  45. JAMA. 2002 Jun 26;287(24):3230-7 - PubMed
  46. Diabetologia. 1995 Dec;38(12):1425-33 - PubMed
  47. Exp Clin Endocrinol Diabetes. 1996;104(3):284-8 - PubMed
  48. JAMA. 2005 Jan 19;293(3):320-9 - PubMed
  49. J Am Board Fam Pract. 2003 Jan-Feb;16(1):47-57 - PubMed
  50. J Hum Hypertens. 1999 Mar;13(3):203-8 - PubMed
  51. Free Radic Res. 1999 Sep;31(3):171-9 - PubMed
  52. J Intern Med. 2007 Aug;262(2):208-14 - PubMed
  53. J Am Diet Assoc. 2006 Dec;106(12):1966-74 - PubMed
  54. Hypertension. 2006 Feb;47(2):296-308 - PubMed
  55. Arterioscler Thromb Vasc Biol. 2001 Dec;21(12):2072-9 - PubMed
  56. Gend Med. 2008;5 Suppl A:S76-90 - PubMed
  57. N Engl J Med. 2007 Apr 12;356(15):1499-501 - PubMed
  58. J Am Coll Nutr. 1998 Apr;17(2):116-23 - PubMed
  59. Diabetes Care. 2003 Dec;26(12):3215-8 - PubMed
  60. Indian J Exp Biol. 1992 Jun;30(6):523-6 - PubMed
  61. Diabet Med. 2001 Sep;18(9):756-60 - PubMed
  62. Hypertension. 1982 Sep-Oct;4(5 Pt 2):III128-34 - PubMed
  63. J Intern Med. 2002 Dec;252(6):497-503 - PubMed
  64. Biomed Pharmacother. 1998;52(2):89-95 - PubMed
  65. N Engl J Med. 2002 Dec 19;347(25):2046-56 - PubMed
  66. Biochem Biophys Res Commun. 1991 Aug 30;179(1):615-9 - PubMed
  67. Altern Ther Health Med. 2001 May-Jun;7(3):79-91 - PubMed
  68. N Engl J Med. 1991 Sep 26;325(13):938-48 - PubMed
  69. Thromb Res. 1998 Aug 1;91(3):105-12 - PubMed
  70. Am J Physiol. 1994 Feb;266(2 Pt 1):E261-8 - PubMed
  71. Am J Clin Nutr. 1993 May;57(5):650-6 - PubMed
  72. CMAJ. 1999 May 4;160(9 Suppl):S35-45 - PubMed
  73. Arzneimittelforschung. 1995 Aug;45(8):872-4 - PubMed
  74. J Hypertens Suppl. 1996 Dec;14(5):S139-45 - PubMed
  75. Heart Dis. 2000 Jan-Feb;2(1):3-9 - PubMed
  76. Am J Hypertens. 2001 Sep;14(9 Pt 1):971-5 - PubMed
  77. Indian J Med Res. 2010 Nov;132:531-42 - PubMed
  78. Diabetes Care. 2006 Aug;29(8):1826-32 - PubMed
  79. Chem Res Toxicol. 2007 Apr;20(4):577-82 - PubMed
  80. Evid Based Complement Alternat Med. 2013;2013:929074 - PubMed
  81. Eur Rev Med Pharmacol Sci. 2009 Jan-Feb;13(1):51-5 - PubMed
  82. J Clin Endocrinol Metab. 2001 Mar;86(3):1410-7 - PubMed
  83. Metabolism. 1996 Sep;45(9):1130-5 - PubMed
  84. Am J Emerg Med. 2001 Sep;19(5):337-95 - PubMed
  85. J Clin Biochem Nutr. 2010 Sep;47(2):98-106 - PubMed
  86. J Nutr Sci Vitaminol (Tokyo). 2005 Oct;51(5):335-42 - PubMed
  87. Int J Epidemiol. 2006 Jun;35(3):556-8 - PubMed
  88. Med Hypotheses. 1991 Oct;36(2):140-1 - PubMed
  89. Diabetes Res Clin Pract. 2006 Mar;71(3):356-8 - PubMed
  90. Lancet. 1993 Feb 20;341(8843):454-7 - PubMed
  91. Am J Clin Nutr. 1997 Feb;65(2 Suppl):712S-716S - PubMed
  92. Arch Intern Med. 2007 May 14;167(9):956-65 - PubMed
  93. J Am Coll Nutr. 1995 Aug;14(4):387-92 - PubMed
  94. Br J Psychiatry Suppl. 2004 Apr;47:S55-63 - PubMed
  95. Diabetes Care. 2004 Nov;27(11):2741-51 - PubMed
  96. Circulation. 2000 Jan 25;101(3):329-35 - PubMed
  97. J Clin Hypertens (Greenwich). 2012 Jul;14(7):467-71 - PubMed
  98. Am J Clin Nutr. 2002 Jul;76(1):148-55 - PubMed
  99. Cell Mol Life Sci. 2000 Dec;57(13-14):1874-9 - PubMed
  100. Am J Health Syst Pharm. 2000 Jul 15;57(14):1361-2 - PubMed
  101. Altern Med Rev. 2002 Feb;7(1):45-58 - PubMed
  102. Hypertension. 1999 Oct;34(4 Pt 2):1002-6 - PubMed
  103. Brain Res. 2000 Dec 29;887(2):436-9 - PubMed

MeSH terms

Publication Types