Display options
Cite
Nasiri J, Kargar M. Combination of citicoline and physiotherapy in children with cerebral palsy. Int J Prev Med. 2014;5(10):1308-13
Nasiri, J., & Kargar, M. (2014). Combination of citicoline and physiotherapy in children with cerebral palsy. International journal of preventive medicine, 5(10), 1308-13.
Nasiri, Jafar, and Kargar, Mehran. "Combination of citicoline and physiotherapy in children with cerebral palsy." International journal of preventive medicine vol. 5,10 (2014): 1308-13.
Nasiri J, Kargar M. Combination of citicoline and physiotherapy in children with cerebral palsy. Int J Prev Med. 2014 Oct;5(10):1308-13. PMID: 25400890; PMCID: PMC4223951.
Copy Download .nbib Format: NLM
Share it on

Int J Prev Med. 2014 Oct;5(10):1308-13.

Combination of citicoline and physiotherapy in children with cerebral palsy.

International journal of preventive medicine

Jafar Nasiri, Mehran Kargar

Affiliations

  1. Department of Pediatrics, Faculty of Medicine, Child Growth and Development Research Center, Research Institute for Primary Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 25400890 PMCID: PMC4223951

Abstract

BACKGROUND: The most common cause of physical disability in children is cerebral palsy. This study was aimed to evaluate the effect of citicoline in combination to physiotherapy versus physiotherapy alone, to improve the functional outcome in pediatric cerebral palsy.

METHODS: The clinical trial was performed on 50 pediatric patients aged 18-75 months with spastic diplegia or quadriplegic cerebral palsy. Patients were assessed in two groups: case group, under treatment, using injection of citicoline (10 mg/kg) every other day for 3 months and physiotherapy. Gross motor function classification system (GMFCS) levels were assessed in all patients before and after treatment.

RESULTS: Patient's mean age was 38.7 ± 17.2 months, and 52% were girls. Differences in the frequency of GMFCS levels between groups were not statistically significant, before (P = 0.09) and after (P = 0.47) treatment. In case group improving in GMFCS, level was occurred in 9/11 with level 2 to level 1, 3/5 with level 3 to other levels and 3/7 with level 4 to other levels. In the control group improving in GMFCS, level was occurred in 3/9 with level 2 to level 1, 3/10 with level 3 to other levels, and 2/4 with level 4 other levels. GMFCS level in 64% of cases was improved, whereas in control group, 32% was improved (P = 0.02).

CONCLUSIONS: Results demonstrated that citicoline in combination to physiotherapy appears to be a promising agent to improve gross motor function in patients with cerebral palsy versus physiotherapy alone. Although, further studies are need to be done.

Keywords: Cerebral palsy; citicoline; gross motor function classification system

References

  1. Brain. 2012 Jan;135(Pt 1):276-84 - PubMed
  2. Stroke. 1988 Feb;19(2):211-6 - PubMed
  3. Dev Med Child Neurol. 2007 Feb;49(s109):1-44 - PubMed
  4. J Neurosci Res. 2002 Oct 15;70(2):133-9 - PubMed
  5. Pediatrics. 2011 Nov;128(5):e1321-9 - PubMed
  6. Dev Med Child Neurol. 2012 Jul;54(7):640-6 - PubMed
  7. Expert Rev Pharmacoecon Outcomes Res. 2008 Apr;8(2):151-7 - PubMed
  8. Expert Opin Pharmacother. 2009 Apr;10(5):839-46 - PubMed
  9. Rev Neurol. 2012 Feb 1;54(3):173-9 - PubMed
  10. Lancet Neurol. 2011 Sep;10(9):844-52 - PubMed
  11. Neurochem Res. 1981 Aug;6(8):821-33 - PubMed
  12. Rev Neurol. 2011 Mar 14;52 Suppl 2:S1-S62 - PubMed
  13. Expert Opin Biol Ther. 2011 Apr;11(4):463-71 - PubMed
  14. Neurotherapeutics. 2011 Jul;8(3):434-51 - PubMed
  15. Clin Perinatol. 2006 Jun;33(2):251-67 - PubMed
  16. Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(3 Pt 2):21-6 - PubMed
  17. Neurology. 2001 Nov 13;57(9):1595-602 - PubMed
  18. Dev Med Child Neurol Suppl. 2007 Feb;109:8-14 - PubMed
  19. J Neurosci Rural Pract. 2011 Jan;2(1):43-9 - PubMed
  20. Clin Interv Aging. 2012;7:113-8 - PubMed
  21. Expert Opin Biol Ther. 2003 Jul;3(4):541-9 - PubMed
  22. Stroke. 2011 Jan;42(1 Suppl):S40-3 - PubMed
  23. Zh Nevrol Psikhiatr Im S S Korsakova. 2009;109(12 Suppl 2):51-4 - PubMed
  24. Eur J Neurol. 2001 Nov;8 Suppl 5:136-44 - PubMed

Publication Types