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Madabhavi I, Patel A, Choudhary M, et al. Paraneoplastic recurrent hypoglycaemic seizures: an initial presentation of hepatoblastoma in an adolescent male-a rare entity. Case Rep Pediatr. 2014;2014:104543doi: 10.1155/2014/104543.
Madabhavi, I., Patel, A., Choudhary, M., Aagre, S., Revannasiddaiah, S., Modi, G., Anand, A., Panchal, H., Parikh, S., & Raut, S. (2014). Paraneoplastic recurrent hypoglycaemic seizures: an initial presentation of hepatoblastoma in an adolescent male-a rare entity. Case reports in pediatrics, 2014104543. https://doi.org/10.1155/2014/104543
Madabhavi, Irappa, et al. "Paraneoplastic recurrent hypoglycaemic seizures: an initial presentation of hepatoblastoma in an adolescent male-a rare entity." Case reports in pediatrics vol. 2014 (2014): 104543. doi: https://doi.org/10.1155/2014/104543
Madabhavi I, Patel A, Choudhary M, Aagre S, Revannasiddaiah S, Modi G, Anand A, Panchal H, Parikh S, Raut S. Paraneoplastic recurrent hypoglycaemic seizures: an initial presentation of hepatoblastoma in an adolescent male-a rare entity. Case Rep Pediatr. 2014;2014:104543. doi: 10.1155/2014/104543. Epub 2014 Nov 30. PMID: 25525545; PMCID: PMC4267168.
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Case Rep Pediatr. 2014;2014:104543. doi: 10.1155/2014/104543. Epub 2014 Nov 30.

Paraneoplastic recurrent hypoglycaemic seizures: an initial presentation of hepatoblastoma in an adolescent male-a rare entity.

Case reports in pediatrics

Irappa Madabhavi, Apurva Patel, Mukesh Choudhary, Suhas Aagre, Swaroop Revannasiddaiah, Gaurang Modi, Asha Anand, Harsha Panchal, Sonia Parikh, Shreeniwas Raut

Affiliations

  1. Department of Medical and Paediatric Oncology, GCRI, Ahmedabad, Gujarat 380016, India.
  2. Department of Radiotherapy, Government Medical College, Haldwani, India.

PMID: 25525545 PMCID: PMC4267168 DOI: 10.1155/2014/104543

Abstract

Hepatoblastoma (HB) is a rare malignant tumour of the liver and usually occurs in the first three years of life. Hepatoblastoma in adolescents and young adults is extremely rare; nevertheless the prognosis is much worse than in childhood, because these kinds of tumours are usually diagnosed late. Characteristic imaging and histopathological and AFP levels help in the diagnosis of hepatoblastoma. Paraneoplastic features of hepatoblastoma are not uncommon at presentation and include erythrocytosis, thrombocytosis, hypocalcaemia, isosexual precocious puberty, and rarely hypoglycaemia. Even though hypoglycaemia is commonly seen in hepatocellular carcinoma, its association with hepatoblastoma is very rare. We present a case of 15-year-old male patient presenting with complaints of recurrent hypoglycaemic seizures ultimately leading to diagnosis of hepatoblastoma. Managed successfully with neoadjuvant chemotherapy, surgery and adjuvant chemotherapy with adriamycin and cisplatin based regimens. An extensive review of literature in the PubMed and MEDLINE did not reveal much data on paraneoplastic recurrent hypoglycaemic seizures as an initial presentation of hepatoblastomas in adolescents and young adults.

References

  1. J Pediatr Surg. 2004 Dec;39(12):1775-8 - PubMed
  2. J Clin Oncol. 2000 Jul;18(14):2665-75 - PubMed
  3. World J Gastroenterol. 2005 Oct 21;11(39):6235-7 - PubMed
  4. Cancer. 2003 Aug 15;98(4):668-78 - PubMed
  5. J Clin Oncol. 2005 Feb 20;23(6):1245-52 - PubMed
  6. J Korean Med Sci. 1997 Aug;12(4):369-73 - PubMed
  7. J Pathol. 2003 Oct;201(2):250-9 - PubMed
  8. Semin Surg Oncol. 1999 Mar;16(2):159-72 - PubMed
  9. Med Pediatr Oncol. 1980;8(4):335-41 - PubMed
  10. Pediatr Radiol. 2006 Mar;36(3):187-91 - PubMed
  11. Cancer Genet Cytogenet. 2005 Jan 1;156(1):8-13 - PubMed
  12. Cancer. 1999 Sep 1;86(5):799-804 - PubMed
  13. Hepatogastroenterology. 1996 Jul-Aug;43(10):1073-8 - PubMed
  14. Ann Hepatol. 2006 Jul-Sep;5(3):179-81 - PubMed
  15. Eur J Cancer. 2004 Feb;40(3):411-21 - PubMed

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