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Li C, Kim K. Family of FLP Peptides in Caenorhabditis elegans and Related Nematodes. Front Endocrinol (Lausanne). 2014;5:150doi: 10.3389/fendo.2014.00150.
Li, C., & Kim, K. (2014). Family of FLP Peptides in Caenorhabditis elegans and Related Nematodes. Frontiers in endocrinology, 5150. https://doi.org/10.3389/fendo.2014.00150
Li, Chris, and Kim, Kyuhyung. "Family of FLP Peptides in Caenorhabditis elegans and Related Nematodes." Frontiers in endocrinology vol. 5 (2014): 150. doi: https://doi.org/10.3389/fendo.2014.00150
Li C, Kim K. Family of FLP Peptides in Caenorhabditis elegans and Related Nematodes. Front Endocrinol (Lausanne). 2014 Oct 14;5:150. doi: 10.3389/fendo.2014.00150. eCollection 2014. PMID: 25352828; PMCID: PMC4196577.
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Front Endocrinol (Lausanne). 2014 Oct 14;5:150. doi: 10.3389/fendo.2014.00150. eCollection 2014.

Family of FLP Peptides in Caenorhabditis elegans and Related Nematodes.

Frontiers in endocrinology

Chris Li, Kyuhyung Kim

Affiliations

  1. Department of Biology, City College of New York and The Graduate Center, City University of New York , New York, NY , USA.
  2. Department of Brain Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST) , Daegu , South Korea.

PMID: 25352828 PMCID: PMC4196577 DOI: 10.3389/fendo.2014.00150

Abstract

Neuropeptides regulate all aspects of behavior in multicellular organisms. Because of their ability to act at long distances, neuropeptides can exert their effects beyond the conventional synaptic connections, thereby adding an intricate layer of complexity to the activity of neural networks. In the nematode Caenorhabditis elegans, a large number of neuropeptide genes that are expressed throughout the nervous system have been identified. The actions of these peptides supplement the synaptic connections of the 302 neurons, allowing for fine tuning of neural networks and increasing the ways in which behaviors can be regulated. In this review, we focus on a large family of genes encoding FMRFamide-related peptides (FaRPs). These genes, the flp genes, have been used as a starting point to identifying flp genes throughout Nematoda. Nematodes have the largest family of FaRPs described thus far. The challenges in the future are the elucidation of their functions and the identification of the receptors and signaling pathways through which they function.

Keywords: behavior; nematodes; neural circuits; neuropeptides; worms

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