Display options
Cite
Hingorani DV, Bernstein AS, Pagel MD. A review of responsive MRI contrast agents: 2005-2014. Contrast Media Mol Imaging. 2014;10(4):245-65doi: 10.1002/cmmi.1629.
Hingorani, D. V., Bernstein, A. S., & Pagel, M. D. (2015). A review of responsive MRI contrast agents: 2005-2014. Contrast media & molecular imaging, 10(4), 245-65. https://doi.org/10.1002/cmmi.1629
Hingorani, Dina V, et al. "A review of responsive MRI contrast agents: 2005-2014." Contrast media & molecular imaging vol. 10,4 (2015): 245-65. doi: https://doi.org/10.1002/cmmi.1629
Hingorani DV, Bernstein AS, Pagel MD. A review of responsive MRI contrast agents: 2005-2014. Contrast Media Mol Imaging. 2015 Jul-Aug;10(4):245-65. doi: 10.1002/cmmi.1629. Epub 2014 Oct 29. PMID: 25355685; PMCID: PMC4414668.
Copy Download .nbib Format: NLM
Share it on

Contrast Media Mol Imaging. 2015 Jul-Aug;10(4):245-65. doi: 10.1002/cmmi.1629. Epub 2014 Oct 29.

A review of responsive MRI contrast agents: 2005-2014.

Contrast media & molecular imaging

Dina V Hingorani, Adam S Bernstein, Mark D Pagel

Affiliations

  1. Department of Chemistry and Biochemistry, University of Arizona, USA.
  2. Department of Biomedical Engineering, University of Arizona, USA.
  3. Department of Medical Imaging, University of Arizona, USA.
  4. University of Arizona Cancer Center, University of Arizona, USA.

PMID: 25355685 PMCID: PMC4414668 DOI: 10.1002/cmmi.1629

Abstract

This review focuses on MRI contrast agents that are responsive to a change in a physiological biomarker. The response mechanisms are dependent on six physicochemical characteristics, including the accessibility of water to the agent, tumbling time, proton exchange rate, electron spin state, MR frequency or superparamagnetism of the agent. These characteristics can be affected by changes in concentrations or activities of enzymes, proteins, nucleic acids, metabolites, or metal ions, or changes in redox state, pH, temperature, or light. A total of 117 examples are presented, including ones that employ nuclei other than (1) H, which attests to the creativity of multidisciplinary research efforts to develop responsive MRI contrast agents.

Copyright © 2014 John Wiley & Sons, Ltd.

Keywords: CEST agents; MRI contrast agents; MRS agents; T1 agents; T2* agents; hyperpolarized agents; responsive agents

References

  1. Analyst. 2013 Nov 7;138(21):6266-9 - PubMed
  2. Hum Gene Ther. 2005 Dec;16(12):1429-38 - PubMed
  3. Ital J Biochem. 2006 Sep-Dec;55(3-4):263-82 - PubMed
  4. NMR Biomed. 2012 Nov;25(11):1286-94 - PubMed
  5. Mol Biosyst. 2012 Oct;8(10):2733-40 - PubMed
  6. Magn Reson Med. 2007 Nov;58(5):1072-7 - PubMed
  7. J Comput Tomogr. 1981 Dec;5(6):543-7 - PubMed
  8. Magn Reson Imaging. 2013 Jul;31(6):900-10 - PubMed
  9. Magn Reson Med. 2013 Oct;70(4):1016-25 - PubMed
  10. Inorg Chem. 2012 Sep 3;51(17):9153-5 - PubMed
  11. Mol Imaging. 2012 Feb;11(1):47-57 - PubMed
  12. Curr Med Chem. 2005;12(7):819-48 - PubMed
  13. Int J Cancer. 2010 Aug 1;127(3):729-36 - PubMed
  14. Magn Reson Med. 2012 Dec;68(6):1764-73 - PubMed
  15. Tetrahedron. 2009 Feb;65(7):1241 - PubMed
  16. Mitochondrion. 2013 May;13(3):246-53 - PubMed
  17. Biomaterials. 2014 Jan;35(1):337-43 - PubMed
  18. NMR Biomed. 2011 Dec;24(10):1226-34 - PubMed
  19. J Med Chem. 2009 Mar 26;52(6):1576-81 - PubMed
  20. Novartis Found Symp. 2001;240:199-211; discussion 265-8 - PubMed
  21. Breast Cancer Res. 2005;7(4):149-52 - PubMed
  22. Inorg Chem. 2013 Mar 4;52(5):2277-9 - PubMed
  23. Chembiochem. 2007 Sep 24;8(14):1637-41 - PubMed
  24. Contrast Media Mol Imaging. 2009 Sep-Oct;4(5):220-9 - PubMed
  25. J Magn Reson. 2010 Jan;202(1):85-92 - PubMed
  26. J Magn Reson. 2013 Mar;228:59-65 - PubMed
  27. J Control Release. 2010 Apr 2;143(1):120-7 - PubMed
  28. Magn Reson Med. 2012 Dec;68(6):1919-23 - PubMed
  29. Magn Reson Med. 2012 Mar;67(3):760-8 - PubMed
  30. Bioconjug Chem. 2007 Nov-Dec;18(6):1716-27 - PubMed
  31. Angew Chem Int Ed Engl. 2011 Feb 18;50(8):1798-800 - PubMed
  32. Contrast Media Mol Imaging. 2007 Jan-Feb;2(1):50-4 - PubMed
  33. J Nanobiotechnology. 2011;9:7 - PubMed
  34. Magn Reson Med. 2009 Mar;61(3):615-25 - PubMed
  35. Neuro Oncol. 2012 Mar;14(3):315-25 - PubMed
  36. J Am Chem Soc. 2011 Oct 19;133(41):16326-9 - PubMed
  37. J Am Chem Soc. 2008 Jan 23;130(3):794-5 - PubMed
  38. J Am Chem Soc. 2009 Jun 24;131(24):8527-36 - PubMed
  39. J Control Release. 2011 Sep 5;154(2):196-202 - PubMed
  40. Nat Med. 2012 Feb;18(2):302-6 - PubMed
  41. J Am Chem Soc. 2009 Jan 21;131(2):563-9 - PubMed
  42. J Am Chem Soc. 2012 Jan 18;134(2):934-43 - PubMed
  43. Tetrahedron Lett. 2009 Aug 5;50(31):4459-4462 - PubMed
  44. Magn Reson Med. 2008 Feb;59(2):374-81 - PubMed
  45. Contrast Media Mol Imaging. 2011 Jul-Aug;6(4):219-28 - PubMed
  46. Nucleic Acids Res. 2006;34(6):e51 - PubMed
  47. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10589-93 - PubMed
  48. Diabetes Metab Res Rev. 2013 Feb;29(2):125-9 - PubMed
  49. Radiology. 1990 Jul;176(1):211-20 - PubMed
  50. Angew Chem Int Ed Engl. 2008;47(23):4370-2 - PubMed
  51. Cancer Res. 2009 Mar 15;69(6):2260-8 - PubMed
  52. Bioconjug Chem. 2011 Dec 21;22(12):2625-35 - PubMed
  53. Curr Opin Chem Biol. 2010 Feb;14(1):80-9 - PubMed
  54. Chem Commun (Camb). 2007 Oct 21;(39):4044-6 - PubMed
  55. Angew Chem Int Ed Engl. 2005 Oct 28;44(42):6920-3 - PubMed
  56. Angew Chem Int Ed Engl. 2001 Aug 3;40(15):2903-2906 - PubMed
  57. Biomaterials. 2014 Jan;35(1):304-15 - PubMed
  58. Magn Reson Med. 2014 Nov;72(5):1408-17 - PubMed
  59. Magn Reson Med. 2011 Jan;65(1):202-11 - PubMed
  60. J Cell Biochem. 2003 Oct 15;90(3):518-24 - PubMed
  61. Magn Reson Med. 2006 Jun;55(6):1272-80 - PubMed
  62. Cancer Biomark. 2009;5(2):99-107 - PubMed
  63. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18400-5 - PubMed
  64. Life Sci. 2012 Mar 10;90(11-12):381-7 - PubMed
  65. NMR Biomed. 2012 Feb;25(2):305-11 - PubMed
  66. Front Biosci (Schol Ed). 2011;3:331-40 - PubMed
  67. Neurocrit Care. 2011 Feb;14(1):127-33 - PubMed
  68. Bioorg Med Chem. 2011 Feb 1;19(3):1097-105 - PubMed
  69. Mol Imaging. 2003 Oct;2(4):333-41 - PubMed
  70. Chem Sci. 2011 Jun;2(6):1103-1110 - PubMed
  71. Bioorg Med Chem. 2011 Feb 1;19(3):1115-22 - PubMed
  72. NMR Biomed. 2005 Apr;18(2):74-82 - PubMed
  73. Magn Reson Med. 2007 Dec;58(6):1249-56 - PubMed
  74. Curr Opin Chem Biol. 2010 Feb;14(1):97-104 - PubMed
  75. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2798-802 - PubMed
  76. J Am Chem Soc. 2013 Jun 19;135(24):8966-72 - PubMed
  77. J Mol Biol. 2012 Sep 14;422(2):245-62 - PubMed
  78. Chemphyschem. 2007 Oct 8;8(14):2082-5 - PubMed
  79. Magn Reson Med. 2011 May;65(5):1253-9 - PubMed
  80. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18606-11 - PubMed
  81. JAMA. 2012 Jun 13;307(22):2400-9 - PubMed
  82. Magn Reson Med. 2010 Jul;64(1):65-71 - PubMed
  83. Nat Med. 2013 Aug;19(8):1067-72 - PubMed
  84. Magn Reson Med. 2009 Jan;61(1):244-8 - PubMed
  85. NMR Biomed. 2011 Dec;24(10):1380-91 - PubMed
  86. Contrast Media Mol Imaging. 2007 Jul;2(4):163-71 - PubMed
  87. Magn Reson Med. 2007 Feb;57(2):442-7 - PubMed
  88. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E958-67 - PubMed
  89. Inorg Chem. 2006 Jun 26;45(13):5092-102 - PubMed
  90. AJR Am J Roentgenol. 1983 Nov;141(5):1019-23 - PubMed
  91. Acc Chem Res. 2003 Oct;36(10):783-90 - PubMed
  92. Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4100-3 - PubMed
  93. Mol Pharm. 2011 Oct 3;8(5):1970-4 - PubMed
  94. J Am Chem Soc. 2012 Nov 14;134(45):18503-5 - PubMed
  95. Inorg Chem. 2002 Jul 29;41(15):4018-24 - PubMed
  96. Angew Chem Int Ed Engl. 2010 Mar 22;49(13):2382-4 - PubMed
  97. J Am Chem Soc. 2013 May 1;135(17):6396-8 - PubMed
  98. Small. 2010 Jun 6;6(11):1201-4 - PubMed
  99. Chemistry. 2011 Jan 3;17(1):223-30 - PubMed
  100. Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):425-32 - PubMed
  101. J Am Chem Soc. 2010 Feb 17;132(6):1784-5 - PubMed
  102. J Am Chem Soc. 2005 Dec 21;127(50):17572-3 - PubMed
  103. Chem Commun (Camb). 2011 May 7;47(17):4998-5000 - PubMed
  104. J Biol Chem. 2011 Jul 15;286(28):24572-80 - PubMed
  105. J Am Chem Soc. 2010 May 5;132(17):5934-5 - PubMed
  106. Curr Med Imaging Rev. 2009 May 1;3(2):91-107 - PubMed
  107. Neuroimage. 2011 Feb 1;54(3):2079-85 - PubMed
  108. Biomaterials. 2012 Oct;33(29):7126-37 - PubMed
  109. Bioorg Med Chem. 2011 Feb 1;19(3):1131-5 - PubMed
  110. Proc Natl Acad Sci U S A. 2014 May 6;111(18):6588-93 - PubMed
  111. Front Biosci. 2008;13:1733-52 - PubMed
  112. Dalton Trans. 2013 Jun 14;42(22):8066-9 - PubMed
  113. Magn Reson Med. 2014 Jan;71(1):164-72 - PubMed
  114. Biomaterials. 2013 Jun;34(17):4387-93 - PubMed
  115. Eur Radiol. 2010 Oct;20(10):2461-74 - PubMed
  116. Inorg Chem. 2012 Jul 16;51(14):7448-50 - PubMed
  117. J Am Chem Soc. 2010 Jan 13;132(1):168-77 - PubMed
  118. Circulation. 1982 Nov;66(5):1012-6 - PubMed
  119. Cell Mol Biol (Noisy-le-grand). 2000 Jun;46(4):731-41 - PubMed
  120. J Am Chem Soc. 2013 Mar 27;135(12):4620-3 - PubMed
  121. J Magn Reson. 2000 Mar;143(1):79-87 - PubMed
  122. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8443-8 - PubMed
  123. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10780-5 - PubMed
  124. NMR Biomed. 2008 Oct;21(8):899-907 - PubMed
  125. Contrast Media Mol Imaging. 2012 Sep-Oct;7(5):478-83 - PubMed
  126. Angew Chem Int Ed Engl. 2005 Feb 4;44(7):1004-11 - PubMed
  127. Chembiochem. 2012 Jul 23;13(11):1579-83 - PubMed
  128. Chem Commun (Camb). 2013 Nov 4;49(85):10025-7 - PubMed
  129. Org Lett. 2013 Sep 20;15(18):4702-5 - PubMed
  130. Nat Biotechnol. 2010 Mar;28(3):264-70 - PubMed
  131. Radiology. 1982 Jul;144(2):343-7 - PubMed
  132. Acc Chem Res. 2009 Jul 21;42(7):893-903 - PubMed
  133. Sci Rep. 2013;3:1024 - PubMed
  134. Nat Med. 2005 Apr;11(4):450-4 - PubMed
  135. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5205-10 - PubMed
  136. J Med Chem. 2013 Mar 28;56(6):2466-77 - PubMed
  137. J Am Chem Soc. 2010 Oct 13;132(40):14002-3 - PubMed
  138. Magn Reson Med. 2008 Aug;60(2):253-7 - PubMed
  139. Mol Imaging. 2007 Nov-Dec;6(6):393-403 - PubMed
  140. Magn Reson Imaging. 1994;12(1):61-9 - PubMed
  141. Science. 2006 Apr 14;312(5771):217-24 - PubMed
  142. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13881-6 - PubMed
  143. Int J Hyperthermia. 2005 Sep;21(6):515-31 - PubMed
  144. Biomaterials. 2014 Jan;35(1):356-67 - PubMed
  145. Chem Commun (Camb). 2008 Aug 7;(29):3444-6 - PubMed
  146. Org Biomol Chem. 2010 Dec 7;8(23):5333-8 - PubMed
  147. Angew Chem Int Ed Engl. 2010 May 25;49(23):3909-11 - PubMed
  148. Magn Reson Med. 2009 Nov;62(5):1300-4 - PubMed
  149. Magn Reson Med. 2010 Mar;63(3):745-53 - PubMed
  150. Contrast Media Mol Imaging. 2010 Sep-Oct;5(5):294-6 - PubMed
  151. J Am Chem Soc. 2009 Aug 19;131(32):11387-91 - PubMed
  152. Magn Reson Med. 2003 Jan;49(1):89-98 - PubMed
  153. Magn Reson Med. 2010 Dec;64(6):1792-9 - PubMed
  154. Angew Chem Int Ed Engl. 2009;48(23):4142-5 - PubMed
  155. J Biol Inorg Chem. 2008 Jan;13(1):35-46 - PubMed
  156. Exp Biol Med (Maywood). 2001 May;226(5):367-76 - PubMed
  157. Bioorg Med Chem. 2012 Jan 15;20(2):769-74 - PubMed
  158. Org Biomol Chem. 2010 Jun 7;8(11):2560-6 - PubMed
  159. Contrast Media Mol Imaging. 2006 Nov-Dec;1(6):267-78 - PubMed
  160. Inorg Chem. 2011 Nov 21;50(22):11568-80 - PubMed
  161. Magn Reson Med. 2008 Oct;60(4):803-12 - PubMed
  162. Bioconjug Chem. 2009 Jul;20(7):1375-82 - PubMed
  163. J Am Chem Soc. 2009 Feb 25;131(7):2484-6 - PubMed
  164. Neuroimage. 2006 Sep;32(3):1142-9 - PubMed
  165. J Am Chem Soc. 2012 Apr 4;134(13):5798-800 - PubMed
  166. J Am Chem Soc. 2009 Apr 1;131(12):4206-7 - PubMed
  167. Lancet. 1984 Mar 3;1(8375):484-6 - PubMed
  168. Contrast Media Mol Imaging. 2013 May-Jun;8(3):289-92 - PubMed
  169. J Am Chem Soc. 2006 Dec 20;128(50):15942-3 - PubMed
  170. J Nucl Med. 2008 Mar;49(3):341-4 - PubMed
  171. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):13997-4000 - PubMed
  172. Philos Trans A Math Phys Eng Sci. 2011 Nov 28;369(1955):4605-19 - PubMed
  173. J Am Chem Soc. 2011 Mar 23;133(11):3776-9 - PubMed
  174. Magn Reson Med. 2014 Mar;71(3):1221-30 - PubMed
  175. NMR Biomed. 2013 Mar;26(3):299-306 - PubMed
  176. J Am Chem Soc. 2009 Dec 9;131(48):17591-6 - PubMed
  177. Magn Reson Med. 2013 Sep;70(3):732-44 - PubMed
  178. Bioconjug Chem. 2008 Dec;19(12):2440-5 - PubMed
  179. Radiology. 1994 Apr;191(1):155-64 - PubMed
  180. NMR Biomed. 2008 Aug;21(7):704-12 - PubMed

Substances

MeSH terms

Publication Types

Grant support