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Nakahara T, Moroi Y, Tashiro A, et al. The interaction of inflammatory cells in granuloma faciale. Dermatol Reports. 2010;2(2):e17doi: 10.4081/dr.2010.e17.
Nakahara, T., Moroi, Y., Tashiro, A., Kiryu, H., & Furue, M. (2010). The interaction of inflammatory cells in granuloma faciale. Dermatology reports, 2(2), e17. https://doi.org/10.4081/dr.2010.e17
Nakahara, Takeshi, et al. "The interaction of inflammatory cells in granuloma faciale." Dermatology reports vol. 2,2 (2010): e17. doi: https://doi.org/10.4081/dr.2010.e17
Nakahara T, Moroi Y, Tashiro A, Kiryu H, Furue M. The interaction of inflammatory cells in granuloma faciale. Dermatol Reports. 2010 Nov 15;2(2):e17. doi: 10.4081/dr.2010.e17. eCollection 2010 Aug 31. PMID: 25386252; PMCID: PMC4211470.
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Dermatol Reports. 2010 Nov 15;2(2):e17. doi: 10.4081/dr.2010.e17. eCollection 2010 Aug 31.

The interaction of inflammatory cells in granuloma faciale.

Dermatology reports

Takeshi Nakahara, Yoichi Moroi, Akari Tashiro, Hiromaro Kiryu, Masutaka Furue

Affiliations

  1. Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;
  2. Department of Dermatopathology, Kiryu Clinic, Fukuoka, Japan.

PMID: 25386252 PMCID: PMC4211470 DOI: 10.4081/dr.2010.e17

Abstract

Granuloma faciale (GF) is a rare chronic inflammatory skin disease characterized by single or multiple reddish-brown cutaneous plaques or nodules. Although this condition is benign, its clinical course is extremely chronic with poor response to therapy. The typical histopathological features of GF include vasculitis with mixed cellular infiltration; however, its etiopathogenesis remains unknown. Here, we describe the case of a 76-year-old man with GF resistant to topical steroids. Biopsy of the lesion revealed i) dense mixed inflammatory cellular infiltrates of lymphocytes, histiocytes, neutrophils, and eosinophils, ii) mild perivascular nuclear dust and swollen endothelium of blood vessels, and iii) a narrow Grenz zone beneath the epidermis. Immunohistochemical staining demonstrated mixed cellular infiltrates intermixed with CD1a(+) dendritic cells, CD68(+) histiocytes, and CD4(+) and CD8(+) T cells.

Keywords: dendritic cells; granuloma faciale; helper T cells; histiocytes

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