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Bednarek A, Jankowski P, Olszanecka A, et al. 24-hour central blood pressure and intermediate cardiovascular phenotypes in untreated subjects. Am J Cardiovasc Dis. 2014;4(4):177-87
Bednarek, A., Jankowski, P., Olszanecka, A., Windak, A., Kawecka-Jaszcz, K., & Czarnecka, D. (2014). 24-hour central blood pressure and intermediate cardiovascular phenotypes in untreated subjects. American journal of cardiovascular disease, 4(4), 177-87.
Bednarek, Agnieszka, et al. "24-hour central blood pressure and intermediate cardiovascular phenotypes in untreated subjects." American journal of cardiovascular disease vol. 4,4 (2014): 177-87.
Bednarek A, Jankowski P, Olszanecka A, Windak A, Kawecka-Jaszcz K, Czarnecka D. 24-hour central blood pressure and intermediate cardiovascular phenotypes in untreated subjects. Am J Cardiovasc Dis. 2014 Dec 29;4(4):177-87. eCollection 2014. PMID: 25628959; PMCID: PMC4299692.
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Am J Cardiovasc Dis. 2014 Dec 29;4(4):177-87. eCollection 2014.

24-hour central blood pressure and intermediate cardiovascular phenotypes in untreated subjects.

American journal of cardiovascular disease

Agnieszka Bednarek, Piotr Jankowski, Agnieszka Olszanecka, Adam Windak, Kalina Kawecka-Jaszcz, Danuta Czarnecka

Affiliations

  1. Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College Kraków, Poland.
  2. Department of Family Medicine, Chair of Internal Medicine and Gerontology, Jagiellonian University Medical College Kraków, Poland.

PMID: 25628959 PMCID: PMC4299692

Abstract

BACKGROUND: Recently, 24-hour monitoring of central systolic blood pressure (SBP) has become available. However, the relation between end-organ damage and the 24-hour central SBP profile and variability has not so far been analyzed. Therefore, the aim of this cross-sectional study was to evaluate the relation between 24-hour central SBP, 24-hour central SBP profile as well as central SBP short-term variability and parameters of cardiac and vascular intermediate phenotypes.

METHODS: The study group consisted of 50 patients with newly diagnosed, untreated hypertension (age 40.4 ± 11.5 years, 35 men) and 50 normotensive subjects (age 38.3 ± 12.0 years, 35 men). Applanation tonometry of the radial artery and the "n-point forward moving average" method were used to determine 24-hour central SBP. Each study participant underwent echocardiography and carotid ultrasonography.

RESULTS: 24-hour, daytime, and nighttime central SBP was related to left ventricle end-diastole diameter (p < 0.05), left ventricular mass index (p < 0.001), relative wall thickness (p < 0.05), E/E' ratio (p < 0.01), and left atrium volume (p < 0.01). The nocturnal central SBP fall was not related to any of the mentioned parameters, whereas parameters of short-term variability were related to IMT in hypertensives only (p < 0.05).

CONCLUSIONS: The present study showed that 24-hour central SBP is related to intermediate cardiac phenotypes as assessed by echocardiography whereas short-term central SBP variability is mainly related to vascular phenotype as determined by IMT.

Keywords: Blood pressure; ambulatory blood pressure monitoring; blood pressure profile; central blood pressure; pressure amplification

References

  1. J Hypertens. 2009 Sep;27(9):1784-8 - PubMed
  2. Am J Hypertens. 2012 Apr;25(4):414-20 - PubMed
  3. Hypertension. 2013 Jun;61(6):1168-76 - PubMed
  4. Hypertens Res. 2012 Jun;35(6):617-23 - PubMed
  5. Hypertension. 2007 Aug;50(2):325-32 - PubMed
  6. Eur Heart J. 2010 Mar;31(6):747-52 - PubMed
  7. Am J Cardiol. 2009 Oct 15;104(8):1098-104 - PubMed
  8. J Hypertens. 2013 Sep;31(9):1731-68 - PubMed
  9. Am J Hypertens. 1991 Nov;4(11):603S-607S - PubMed
  10. J Hypertens. 2013 Oct;31(10):1925-38 - PubMed
  11. Am J Hypertens. 2009 Dec;22(12 ):1235-41 - PubMed
  12. J Am Coll Cardiol. 2011 Feb 22;57(8):951-61 - PubMed
  13. J Hypertens. 2014 Sep;32(9):1805-14 - PubMed
  14. Eur J Echocardiogr. 2008 Jul;9(4):438-48 - PubMed
  15. Hypertension. 2014 Jun;63(6):1148-53 - PubMed
  16. Hypertension. 2011 Aug;58(2):133-5 - PubMed
  17. Cardiovasc Diabetol. 2013 Aug 27;12:122 - PubMed
  18. Am J Hypertens. 2012 Aug;25(8):876-82 - PubMed
  19. J Hypertens. 2009 Mar;27(3):461-7 - PubMed
  20. Int J Cardiol. 2012 Feb 9;154(3):344-7 - PubMed
  21. J Hypertens. 2011 Dec;29(12):2462-8 - PubMed
  22. J Hum Hypertens. 2012 Jan;26(1):14-9 - PubMed
  23. Hypertension. 2007 Jul;50(1):197-203 - PubMed
  24. Hypertension. 2005 Jul;46(1):156-61 - PubMed
  25. Hypertension. 2011 Nov;58(5):825-32 - PubMed
  26. Am J Hypertens. 2011 Jun;24(6):628-34 - PubMed
  27. J Hypertens. 2010 Feb;28(2):384-8 - PubMed
  28. Clin Sci (Lond). 2009 Feb;116(4):273-82 - PubMed
  29. Am J Hypertens. 2012 Jan;25(1):41-5 - PubMed
  30. Cerebrovasc Dis. 2007;23 (1):75-80 - PubMed
  31. Eur Heart J. 2010 Aug;31(15):1865-71 - PubMed
  32. Am J Hypertens. 2013 Jan;26(1):27-33 - PubMed

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