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Del Grande F, Tatizawa-Shiga N, Jalali Farahani S, et al. Chemical shift imaging: preliminary experience as an alternative sequence for defining the extent of a bone tumor. Quant Imaging Med Surg. 2014;4(3):173-80doi: 10.3978/j.issn.2223-4292.2014.05.01.
Del Grande, F., Tatizawa-Shiga, N., Jalali Farahani, S., Chalian, M., & Fayad, L. M. (2014). Chemical shift imaging: preliminary experience as an alternative sequence for defining the extent of a bone tumor. Quantitative imaging in medicine and surgery, 4(3), 173-80. https://doi.org/10.3978/j.issn.2223-4292.2014.05.01
Del Grande, Filippo, et al. "Chemical shift imaging: preliminary experience as an alternative sequence for defining the extent of a bone tumor." Quantitative imaging in medicine and surgery vol. 4,3 (2014): 173-80. doi: https://doi.org/10.3978/j.issn.2223-4292.2014.05.01
Del Grande F, Tatizawa-Shiga N, Jalali Farahani S, Chalian M, Fayad LM. Chemical shift imaging: preliminary experience as an alternative sequence for defining the extent of a bone tumor. Quant Imaging Med Surg. 2014 Jun;4(3):173-80. doi: 10.3978/j.issn.2223-4292.2014.05.01. PMID: 24914418; PMCID: PMC4032920.
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Quant Imaging Med Surg. 2014 Jun;4(3):173-80. doi: 10.3978/j.issn.2223-4292.2014.05.01.

Chemical shift imaging: preliminary experience as an alternative sequence for defining the extent of a bone tumor.

Quantitative imaging in medicine and surgery

Filippo Del Grande, Ney Tatizawa-Shiga, Sahar Jalali Farahani, Majid Chalian, Laura Marie Fayad

Affiliations

  1. 1 The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Medical Institutions, 601 North Wolfe Street, Baltimore, MD 21287, USA ; 2 Ospedale Regionale di Lugano, Via Tesserete, 6900 Lugano, Ti Switzerland.

PMID: 24914418 PMCID: PMC4032920 DOI: 10.3978/j.issn.2223-4292.2014.05.01

Abstract

OBJECTIVE: To investigate chemical shift imaging (CSI) with in-phase and opposed-phase (OP) gradient-echo sequences as an alternative sequence to spin-echo T1 imaging for defining intra-medullary skeletal tumor extent.

METHODS AND MATERIALS: This retrospective HIPAA-compliant study was approved by our institutional institutional review board (IRB). Twenty-three subjects with histologically-proven tumors (17 appendicular, 6 axial) underwent magnetic resonance imaging (MRI) with T1-weighted spin echo (T1SE), fluid-sensitive, CSI, and contrast-enhanced T1 sequences. One observer recorded intra-medullary tumor extent (millimeters), with 153 total measurements on each sequence. Red marrow grade [0 (none), 1 (<50%), 2 (50-75%) and 3 (>75%)] in each bone was recorded. Tumor extent on different sequences was compared (Student's t-test); the impact of red marrow grade on measurements was assessed (Spearman's correlation coefficient).

RESULTS: There was good agreement between measurements of tumor extent on T1SE and CSI sequences in all cases (T1SE-CSI measurement difference range 0-13.2 mm, P>0.05). Measurements from other sequences were significantly different from those of T1SE (P<0.05). As red marrow grade in the bone increased, a significant increase in measurement difference obtained on T1SE and CSI sequences was observed (P<0.001).

CONCLUSIONS: CSI is a potential alternative technique to T1SE imaging for defining the intra-medullary extent of a bone tumor, possibly especially useful in regions with abundant red marrow.

ADVANCE IN KNOWLEDGE: CSI could be an alternative technique to T1SE imaging for defining the intra-medullary extent of bone tumor by abundant red marrow in the surrounding bone.

Keywords: Bone marrow lesion; chemical shift imaging (CSI); magnetic resonance imaging (MRI); red bone marrow

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