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Sun M, Birkenfeld J, de Castro A, et al. OCT 3-D surface topography of isolated human crystalline lenses. Biomed Opt Express. 2014;5(10):3547-61doi: 10.1364/BOE.5.003547.
Sun, M., Birkenfeld, J., de Castro, A., Ortiz, S., & Marcos, S. (2014). OCT 3-D surface topography of isolated human crystalline lenses. Biomedical optics express, 5(10), 3547-61. https://doi.org/10.1364/BOE.5.003547
Sun, Mengchan, et al. "OCT 3-D surface topography of isolated human crystalline lenses." Biomedical optics express vol. 5,10 (2014): 3547-61. doi: https://doi.org/10.1364/BOE.5.003547
Sun M, Birkenfeld J, de Castro A, Ortiz S, Marcos S. OCT 3-D surface topography of isolated human crystalline lenses. Biomed Opt Express. 2014 Sep 11;5(10):3547-61. doi: 10.1364/BOE.5.003547. eCollection 2014 Oct 01. PMID: 25360371; PMCID: PMC4206323.
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Biomed Opt Express. 2014 Sep 11;5(10):3547-61. doi: 10.1364/BOE.5.003547. eCollection 2014 Oct 01.

OCT 3-D surface topography of isolated human crystalline lenses.

Biomedical optics express

Mengchan Sun, Judith Birkenfeld, Alberto de Castro, Sergio Ortiz, Susana Marcos

Affiliations

  1. Instituto de Óptica "Daza de Valdés", Tel: + 34 915616800; Consejo Superior de Investigaciones Científicas. Serrano 121, 28006, Madrid, Spain.

PMID: 25360371 PMCID: PMC4206323 DOI: 10.1364/BOE.5.003547

Abstract

Quantitative 3-D Optical Coherence Tomography was used to measure surface topography of 36 isolated human lenses, and to evaluate the relationship between anterior and posterior lens surface shape and their changes with age. All lens surfaces were fitted to 6th order Zernike polynomials. Astigmatism was the predominant surface aberration in anterior and posterior lens surfaces (accounting for ~55% and ~63% of the variance respectively), followed by spherical terms, coma, trefoil and tetrafoil. The amount of anterior and posterior surface astigmatism did not vary significantly with age. The relative angle between anterior and posterior surface astigmatism axes was on average 36.5 deg, tended to decrease with age, and was >45 deg in 36.1% lenses. The anterior surface RMS spherical term, RMS coma and 3rd order RMS decreased significantly with age. In general, there was a statistically significant correlation between the 3rd and 4th order terms of the anterior and posterior surfaces. Understanding the coordination of anterior and posterior lens surface geometries and their topographical changes with age sheds light into the role of the lens in the optical properties of the eye and the lens aging mechanism.

Keywords: (100.2960) Image analysis; (110.4500) Optical coherence tomography; (200.4560) Optical data processing

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