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Wang Y, Negishi T, Negishi K, et al. Prediction of heart failure in patients with type 2 diabetes mellitus- a systematic review and meta-analysis. Diabetes Res Clin Pract. 2015;108(1):55-66doi: 10.1016/j.diabres.2015.01.011.
Wang, Y., Negishi, T., Negishi, K., & Marwick, T. H. (2015). Prediction of heart failure in patients with type 2 diabetes mellitus- a systematic review and meta-analysis. Diabetes research and clinical practice, 108(1), 55-66. https://doi.org/10.1016/j.diabres.2015.01.011
Wang, Ying, et al. "Prediction of heart failure in patients with type 2 diabetes mellitus- a systematic review and meta-analysis." Diabetes research and clinical practice vol. 108,1 (2015): 55-66. doi: https://doi.org/10.1016/j.diabres.2015.01.011
Wang Y, Negishi T, Negishi K, Marwick TH. Prediction of heart failure in patients with type 2 diabetes mellitus- a systematic review and meta-analysis. Diabetes Res Clin Pract. 2015 Apr;108(1):55-66. doi: 10.1016/j.diabres.2015.01.011. Epub 2015 Jan 20. PMID: 25686509.
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Diabetes Res Clin Pract. 2015 Apr;108(1):55-66. doi: 10.1016/j.diabres.2015.01.011. Epub 2015 Jan 20.

Prediction of heart failure in patients with type 2 diabetes mellitus- a systematic review and meta-analysis.

Diabetes research and clinical practice

Ying Wang, Tomoko Negishi, Kazuaki Negishi, Thomas H Marwick

Affiliations

  1. Menzies Research Institute Tasmania, 17 Liverpool Street, Hobart, TAS, Australia.
  2. Menzies Research Institute Tasmania, 17 Liverpool Street, Hobart, TAS, Australia. Electronic address: [email protected].

PMID: 25686509 DOI: 10.1016/j.diabres.2015.01.011

Abstract

BACKGROUND: Heart failure (HF) is a major cause of mortality and disability in type 2 diabetes mellitus (T2DM). This study sought to improve the assessment of HF risk in patients with T2DM-a step that would be critical for effective HF screening.

METHODS: A systematic literature search was performed on electronic databases including MEDLINE and EMBASE, using MeSH terms 'heart failure', 'risk factor', 'T2DM', 'cardiac dysfunction', 'stage B heart failure', 'incident heart failure', 'risk assessment', 'risk impact', 'risk score', 'predictor', 'prediction' and related free text terms. The search was limited to human studies in full-length publications in English language journal from 1946 to 2014. Univariable and multivariable relative risk (RR) and hazard ratio (HR) were obtained from each study.

RESULTS: Twenty-one studies (n=1111,569, including 507,637 subjects with T2DM) were included in this analysis with a follow-up ranging from 1 to 12 years. Associations between incident HF and risk variables described in ≥3 studies were reported. This association was greatest for insulin use (HR 2.48; 1.24-4.99), HbA1c 7.0-8.0% (2.41; 1.62-3.59), 5 years increase in age (1.47; 1.25-1.73), fasting glucose (1.28; 1.10-1.51 per standard deviation) and HbA1c (1.18; 1.14-1.23 each 1% increase). After adjustment for confounders, there were strong associations with coronary artery disease (1.77; 1.31, 2.39), HbA1c ≥ 10% (1.66; 1.45-1.89), insulin use (1.43; 1.14-1.79), HbA1c 9.0-10.0% (1.31; 1.14-1.50), fasting glucose (1.27; 1.10-1.47 per standard deviation) and 5 years increase in age (1.26; 1.13-1.40).

CONCLUSION: Among patients with T2DM, five common clinical variables are associated with significantly increased risk of incident HF.

Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Keywords: Heart failure; Predictor; Risk factors; Type 2 diabetes mellitus

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