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Genome Announc. 2015 Jan 29;3(1). doi: 10.1128/genomeA.01447-14.

Complete Genome Sequence of Mycobacterium sp. Strain VKM Ac-1817D, Capable of Producing 9α-Hydroxy-androst-4-ene-3,17-dione from Phytosterol.

Genome announcements

Victoriya Y Shtratnikova, Mikhail I Schelkunov, Dmitry V Dovbnya, Yury A Pekov, Eugeny Y Bragin, Vasily V Ashapkin, Marina V Donova

Affiliations

  1. Department of Bioengineering and Bioinformatics, M.V. Lomonosov Moscow State University, Moscow, Russia.
  2. G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
  3. A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russia.
  4. G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow Region, Russia [email protected].

PMID: 25635031 PMCID: PMC4319502 DOI: 10.1128/genomeA.01447-14

Abstract

Mycobacterium sp. strain VKM Ac-1817D is capable of converting phytosterol into 9α-hydroxy androst-4-ene-3,17-dione (9-OH-AD), which is a valuable intermediate for the steroid pharmaceutical industry. Here, a complete genome sequence of the strain is reported. The genome consists of a single circular 6,324,222-bp chromosome with a G+C content of 66.2% and encodes approximately 6,000 CDSs, 54 tRNAs, and 6 rRNAs.

Copyright © 2015 Shtratnikova et al.

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