Display options
Cite
Bansal D, Gudala K, Muthyala H, et al. Prevalence and risk factors of development of peripheral diabetic neuropathy in type 2 diabetes mellitus in a tertiary care setting. J Diabetes Investig. 2014;5(6):714-21doi: 10.1111/jdi.12223.
Bansal, D., Gudala, K., Muthyala, H., Esam, H. P., Nayakallu, R., & Bhansali, A. (2014). Prevalence and risk factors of development of peripheral diabetic neuropathy in type 2 diabetes mellitus in a tertiary care setting. Journal of diabetes investigation, 5(6), 714-21. https://doi.org/10.1111/jdi.12223
Bansal, Dipika, et al. "Prevalence and risk factors of development of peripheral diabetic neuropathy in type 2 diabetes mellitus in a tertiary care setting." Journal of diabetes investigation vol. 5,6 (2014): 714-21. doi: https://doi.org/10.1111/jdi.12223
Bansal D, Gudala K, Muthyala H, Esam HP, Nayakallu R, Bhansali A. Prevalence and risk factors of development of peripheral diabetic neuropathy in type 2 diabetes mellitus in a tertiary care setting. J Diabetes Investig. 2014 Nov;5(6):714-21. doi: 10.1111/jdi.12223. Epub 2014 Apr 02. PMID: 25422773; PMCID: PMC4234236.
Copy Download .nbib Format: NLM
Share it on

J Diabetes Investig. 2014 Nov;5(6):714-21. doi: 10.1111/jdi.12223. Epub 2014 Apr 02.

Prevalence and risk factors of development of peripheral diabetic neuropathy in type 2 diabetes mellitus in a tertiary care setting.

Journal of diabetes investigation

Dipika Bansal, Kapil Gudala, Harini Muthyala, Hari Prasad Esam, Ramya Nayakallu, Anil Bhansali

Affiliations

  1. Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research Mohali, India.
  2. Department of Endocrinology, Postgraduate Institute of Medical Education and Research Chandigarh, India.

PMID: 25422773 PMCID: PMC4234236 DOI: 10.1111/jdi.12223

Abstract

AIMS/INTRODUCTION: The study was carried out to assess the prevalence of diabetic peripheral neuropathy (DPN), compare the prevalence between known diabetes mellitus (KDM) and newly detected diabetes mellitus (NDDM), identify risk factors associated, its prevalence pattern and to assess if any sex-specific differences are present.

MATERIALS AND METHODS: A cross-sectional study was carried out in a tertiary care hospital. Patients with duration of diabetes ≤6 months were considered to be NDDM. DPN was diagnosed by the combination of more than one abnormal result of 10-g monofilament, pinprick sensations and ankle reflexes, and categorized according to the severity level using vibration perception threshold. The study included 1,637 KDM and 369 NDDM patients.

RESULTS: A total of 586 participants were found to have DPN, accounting for 29.2% (95% confidence interval [CI] 27.2-31.2) prevalence. The higher prevalence was observed in KDM compared with NDDM 33.7% (95% CI 31.42-36.01) vs 9.2% (95% CI 6.3-12.2; P < 0.001). Prevalence of mild, moderate, and severe neuropathies was 8.06, 14.55 and 6.63%, respectively. Regression analysis showed age (P < 0.001), duration of diabetes (P < 0.001), dyslipidemia (P = 0.03), glycated hemoglobin (P < 0.001), the presence of other microvascular complications (P < 0.001), macrovascular complications (P = 0.003) and alcoholic status (P < 0.033) to be associated. No sex-specific differences were observed in the mean age at diagnosis of diabetes, mean age at the diagnosis of neuropathy, and duration taken for the DPN development among females and males.

CONCLUSIONS: The study showed a high prevalence (29.2%) of DPN among north Indian type 2 diabetes mellitus patients. Thus, timely screening with earlier detection and intervention would be useful in preventing the progression of neuropathy.

Keywords: Diabetic peripheral neuropathy; Prevalence; Risk factors

References

  1. J Diabetes Complications. 2012 Mar-Apr;26(2):123-8 - PubMed
  2. Int J Diabetes Dev Ctries. 2010 Jan;30(1):11-7 - PubMed
  3. Gend Med. 2010 Dec;7(6):600-15 - PubMed
  4. J Diabetes Complications. 2008 Mar-Apr;22(2):83-7 - PubMed
  5. Prim Care Diabetes. 2007 Sep;1(3):129-34 - PubMed
  6. Pain Med. 2008 Sep;9(6):660-74 - PubMed
  7. Diabetes Care. 2004 Jul;27(7):1591-7 - PubMed
  8. Diabetes Care. 2008 Sep;31(9):1837-41 - PubMed
  9. Neurology. 1991 Jun;41(6):799-807 - PubMed
  10. Pain. 1989 Jul;38(1):25-8 - PubMed
  11. Diabetes Res Clin Pract. 2012 Dec;98(3):524-5 - PubMed
  12. Diabetes Res Clin Pract. 2010 Jun;88(3):289-94 - PubMed
  13. Diabetes Res Clin Pract. 1998 Nov;42(2):131-9 - PubMed
  14. J Diabetes Investig. 2013 Nov 27;4(6):640-50 - PubMed
  15. Diabetes Care. 2008 Aug;31(8):1679-85 - PubMed
  16. Diabetes Care. 1998 Dec;21 Suppl 3:C19-24 - PubMed
  17. Neurology. 1967 Oct;17(10):972-80 - PubMed
  18. Diabet Med. 2003 Feb;20(2):105-13 - PubMed
  19. Diabetes Metab Syndr. 2012 Jul-Sep;6(3):167-72 - PubMed
  20. Diabetes Care. 2006 Jul;29(7):1518-22 - PubMed
  21. J Diabetes Complications. 2007 Sep-Oct;21(5):306-14 - PubMed
  22. Diabetes Res Clin Pract. 2008 Aug;81(2):223-30 - PubMed
  23. Diabet Med. 2008 Apr;25(4):407-12 - PubMed
  24. Diabetes Care. 2005 Jun;28(6):1480-1 - PubMed
  25. Diabetes Care. 1994 Jun;17(6):557-60 - PubMed
  26. J Pain. 2010 Apr;11(4):360-8 - PubMed
  27. Diabetes Care. 1997 May;20(5):836-43 - PubMed
  28. Diabetol Metab Syndr. 2012 May 29;4(1):21 - PubMed
  29. Neurology. 2003 Jan 14;60(1):108-11 - PubMed
  30. Diabetes Care. 2013 May;36(5):1193-9 - PubMed
  31. Indian J Med Sci. 2010 Feb;64(2):51-7 - PubMed
  32. Diabetes Metab Syndr. 2012 Apr-Jun;6(2):85-9 - PubMed
  33. J Diabetes Complications. 2008 May-Jun;22(3):164-70 - PubMed
  34. Diabetes. 1988 Apr;37(4):476-81 - PubMed

Publication Types