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Lange I, Koomoa DL. MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines. FEBS Open Bio. 2014;4:966-75doi: 10.1016/j.fob.2014.10.012.
Lange, I., & Koomoa, D. L. (2014). MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines. FEBS open bio, 4966-75. https://doi.org/10.1016/j.fob.2014.10.012
Lange, Ingo, and Koomoa, Dana-Lynn T. "MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines." FEBS open bio vol. 4 (2014): 966-75. doi: https://doi.org/10.1016/j.fob.2014.10.012
Lange I, Koomoa DL. MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines. FEBS Open Bio. 2014 Oct 30;4:966-75. doi: 10.1016/j.fob.2014.10.012. eCollection 2014. PMID: 25426416; PMCID: PMC4241534.
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FEBS Open Bio. 2014 Oct 30;4:966-75. doi: 10.1016/j.fob.2014.10.012. eCollection 2014.

MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines.

FEBS open bio

Ingo Lange, Dana-Lynn T Koomoa

Affiliations

  1. University of Hawaii at Hilo, The Daniel K. Inouye College of Pharmacy, Hilo, HI 96720, USA.

PMID: 25426416 PMCID: PMC4241534 DOI: 10.1016/j.fob.2014.10.012

Abstract

Neuroblastoma is an extra-cranial solid cancer in children. MYCN gene amplification is a prognostic indicator of poor outcome in neuroblastoma. Recent studies have shown that the multiple steps involved in cell migration are dependent on the availability of intracellular calcium (Ca(2+)). Although significant advances have been made in understanding the role of Ca(2+) during migration, little has been achieved towards understanding its impact on the progression of diseases such as cancer. Interestingly, previous studies showed that cancer cell migration is regulated by TRPM7, a calcium-permeable ion channel. The objective of the current study was to elucidate the mechanism by which MycN promotes NB cell migration and the mechanism regulating TRPM7 expression. The results showed that MycN increased TRPM7 expression, induced TRPM7 channel activity, increased intracellular Ca(2+) signaling, and promoted cell migration in NB cells. The results also showed that inhibition or down-regulation of ornithine decarboxylase (ODC) inhibited TRPM7 expression, a process that was reversed by spermidine. Overall, this study provides evidence that MycN promotes TRPM7 expression and cell migration through a mechanism that involves ODC synthesis of polyamines.

Keywords: Migration; MycN; NB, neuroblastoma; Neuroblastoma; ODC, ornithine decarboxylase; Polyamines; RPE-1, rat pigment epithelial cells; TRPM7; bHLHz, basic helix–loop–helix zipper motif

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