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Bootsma M, Swenne CA, Janssen MJ, et al. Heart rate variability and sympathovagal balance: pharmacological validation. Neth Heart J. 2003;11(6):250-259
Bootsma, M., Swenne, C. A., Janssen, M. J., Cats, V. M., & Schalij, M. J. (2003). Heart rate variability and sympathovagal balance: pharmacological validation. Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 11(6), 250-259.
Bootsma, M, et al. "Heart rate variability and sympathovagal balance: pharmacological validation." Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation vol. 11,6 (2003): 250-259.
Bootsma M, Swenne CA, Janssen MJ, Cats VM, Schalij MJ. Heart rate variability and sympathovagal balance: pharmacological validation. Neth Heart J. 2003 Jun;11(6):250-259. PMID: 25696224; PMCID: PMC2499895.
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Neth Heart J. 2003 Jun;11(6):250-259.

Heart rate variability and sympathovagal balance: pharmacological validation.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

M Bootsma, C A Swenne, M J A Janssen, V Manger Cats, M J Schalij

PMID: 25696224 PMCID: PMC2499895

Abstract

RATIONALE: We validated heart rate (HR) and six time and six frequency domain measures of heart rate variability (HRV) as estimators of autonomic outflow in 44 young healthy male subjects. Gold standards for autonomic outflow were the Rosenblueth-Simeone factors m (sympathetic tone) and n (vagal tone), and the sympathovagal balance m·n, determined by two-stage complete autonomic blockade.

METHODS: Rank correlations were computed between HR and the HRV measures obtained before autonomic blockade, and m, n and m·n. Also, the maximal mean performances (averaged sensitivity and specificity) for HR and HRV as discriminators between low and high values of m, n or m·n were computed.

RESULTS: The spectral HRV measures showed less good correlations and performances than the time domain HRV measures. Correlations with sympathetic tone were all below 0.31. Respiratory sinus arrhythmia during 15 cycles/min metronome breathing was superior in estimating vagal tone and sympathovagal balance (correlations -0.71/-0.73; both performances 0.82), heart rate scored similarly for assessing the sympathovagal balance (correlation 0.71; performance 0.82).

CONCLUSIONS: It does not appear justified to evaluate HR or HRV in terms of sympathetic tone, vagal tone, or sympathovagal balance. HR and HRV are specifically weak in assessing sympathetic tone. Respiratory sinus arrhythmia during 15 cycles/min metronome breathing is superior in assessing vagal tone. Current HRV analysis techniques offer no advantages compared with HR in assessing the sympathovagal balance.

Keywords: Rosenblueth-Simeone model; atropine; heart rate variability; metoprolol; sympathovagal balance

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