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de Zwaan C, Daemen MJ, Hermens WT. Mechanisms of cell death in acute myocardial infarction: pathophysiological implications for treatment. Neth Heart J. 2001;9(1):30-44
de Zwaan, C., Daemen, M. J., & Hermens, W. T. (2001). Mechanisms of cell death in acute myocardial infarction: pathophysiological implications for treatment. Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 9(1), 30-44.
de Zwaan, C, et al. "Mechanisms of cell death in acute myocardial infarction: pathophysiological implications for treatment." Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation vol. 9,1 (2001): 30-44.
de Zwaan C, Daemen MJ, Hermens WT. Mechanisms of cell death in acute myocardial infarction: pathophysiological implications for treatment. Neth Heart J. 2001 Apr;9(1):30-44. PMID: 25696691; PMCID: PMC2499566.
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Neth Heart J. 2001 Apr;9(1):30-44.

Mechanisms of cell death in acute myocardial infarction: pathophysiological implications for treatment.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

C de Zwaan, M J A P Daemen, W Th Hermens

PMID: 25696691 PMCID: PMC2499566

Abstract

The purpose of this review is to draw attention to the growing list of pathophysiological phenomena occurring in blood, the vessel wall and cardiac tissue during myocardial infarction. A further aim is to point to the complexity of factors, contributing to cardiac dysfunction and the implications for therapy, aimed at limiting myocardial cell death. Not all pathophysiological mechanisms have been elucidated yet, indicating the necessity for further research in this area. In addition we describe interventions which have shown promise in animal studies, those which may show promise in humans, and those which are accepted as therapies of choice.

Keywords: acute myocardial infarction; cell death; treatment

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