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Xiao S, Shaw RM. Cardiomyocyte protein trafficking: Relevance to heart disease and opportunities for therapeutic intervention. Trends Cardiovasc Med. 2014;25(5):379-89doi: 10.1016/j.tcm.2014.12.012.
Xiao, S., & Shaw, R. M. (2015). Cardiomyocyte protein trafficking: Relevance to heart disease and opportunities for therapeutic intervention. Trends in cardiovascular medicine, 25(5), 379-89. https://doi.org/10.1016/j.tcm.2014.12.012
Xiao, Shaohua, and Shaw, Robin M. "Cardiomyocyte protein trafficking: Relevance to heart disease and opportunities for therapeutic intervention." Trends in cardiovascular medicine vol. 25,5 (2015): 379-89. doi: https://doi.org/10.1016/j.tcm.2014.12.012
Xiao S, Shaw RM. Cardiomyocyte protein trafficking: Relevance to heart disease and opportunities for therapeutic intervention. Trends Cardiovasc Med. 2015 Jul;25(5):379-89. doi: 10.1016/j.tcm.2014.12.012. Epub 2014 Dec 29. PMID: 25649302; PMCID: PMC4468031.
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Trends Cardiovasc Med. 2015 Jul;25(5):379-89. doi: 10.1016/j.tcm.2014.12.012. Epub 2014 Dec 29.

Cardiomyocyte protein trafficking: Relevance to heart disease and opportunities for therapeutic intervention.

Trends in cardiovascular medicine

Shaohua Xiao, Robin M Shaw

Affiliations

  1. Heart Institute and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
  2. Heart Institute and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA; Department of Medicine, University of California Los Angeles, Los Angeles, CA. Electronic address: [email protected].

PMID: 25649302 PMCID: PMC4468031 DOI: 10.1016/j.tcm.2014.12.012

Abstract

Cardiomyocytes, the individual contractile units of heart muscle, are long-lived and robust. Given the longevity of these cells, it can be easy to overlook their dynamic intracellular environment that contain rapid protein movements and frequent protein turnover. Critical gene transcription and protein translation occur continuously, as well as trafficking and localization of proteins to specific functional zones of cell membrane. As heart failure becomes an increasingly important clinical entity, growing numbers of investigative teams are examining the cell biology of healthy and diseased cardiomyocytes. In this review, we introduce the major architectural structures and types of protein movements within cardiac cells, and then review recent studies that explore the regulation of such movements. We conclude by introducing current translational directions of the basic studies with a focus on novel areas of therapeutic development.

Copyright © 2015 Elsevier Inc. All rights reserved.

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