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Napolitano M, Megna M, Balato A, et al. Systemic Treatment of Pediatric Psoriasis: A Review. Dermatol Ther (Heidelb). 2016;6(2):125-42doi: 10.1007/s13555-016-0117-6.
Napolitano, M., Megna, M., Balato, A., Ayala, F., Lembo, S., Villani, A., & Balato, N. (2016). Systemic Treatment of Pediatric Psoriasis: A Review. Dermatology and therapy, 6(2), 125-42. https://doi.org/10.1007/s13555-016-0117-6
Napolitano, Maddalena, et al. "Systemic Treatment of Pediatric Psoriasis: A Review." Dermatology and therapy vol. 6,2 (2016): 125-42. doi: https://doi.org/10.1007/s13555-016-0117-6
Napolitano M, Megna M, Balato A, Ayala F, Lembo S, Villani A, Balato N. Systemic Treatment of Pediatric Psoriasis: A Review. Dermatol Ther (Heidelb). 2016 Jun;6(2):125-42. doi: 10.1007/s13555-016-0117-6. Epub 2016 Apr 16. PMID: 27085539; PMCID: PMC4906111.
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Dermatol Ther (Heidelb). 2016 Jun;6(2):125-42. doi: 10.1007/s13555-016-0117-6. Epub 2016 Apr 16.

Systemic Treatment of Pediatric Psoriasis: A Review.

Dermatology and therapy

Maddalena Napolitano, Matteo Megna, Anna Balato, Fabio Ayala, Serena Lembo, Alessia Villani, Nicola Balato

Affiliations

  1. Department of Dermatology, University of Naples Federico II, Naples, Italy.
  2. Department of Dermatology, University of Naples Federico II, Naples, Italy. [email protected].

PMID: 27085539 PMCID: PMC4906111 DOI: 10.1007/s13555-016-0117-6

Abstract

Psoriasis is a chronic, immune-mediated, inflammatory skin disease, affecting 1-3% of the white population. Although the existence of two psoriasis incidence peaks has been suggested (one in adolescence before 20 years of age and another in adulthood), its onset may occur at any age, including childhood and adolescence, in which the incidence is now estimated at 40.8 per 100,000. As for adult psoriasis, pediatric psoriasis has recently been associated with obesity, metabolic syndrome, increased waist circumference percentiles and metabolic laboratory abnormalities, warranting early monitoring and lifestyle modifications. In addition, due to psoriasis' chronic nature and frequently occurring relapses, psoriatic patients tend to have an impaired quality of life, often requiring long-term treatment. Therefore, education of both pediatric patients and their parents is essential to successful and safe disease management. Given the lack of officially approved therapies, the very limited evidence-based data from randomized controlled trials, and the absence of standardized guidelines, to date, pediatric psoriasis treatment is primarily based on published case reports, case series, guidelines for adult psoriasis, expert opinions and experience with these drugs in other pediatric disorders coming from the disciplines of rheumatology, gastroenterology and oncology. This review focuses on the use of systemic treatments in pediatric psoriasis and their specific features, analyzing the few literature evidences available, expanding the treatment repertoire and guiding dermatologists in better managing of recalcitrant pediatric psoriasis.

Keywords: Biologics; Childhood; Pediatric psoriasis; Systemic treatments

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