Display options
Cite
Schattner A, Nissim F, Berrebi A. Cured Multiple Myeloma Followed by Primary Malignant Lymphoma of the Lung. Leuk Lymphoma. 1991;5(5):441-5doi: 10.3109/10428199109067641.
Schattner, A., Nissim, F., & Berrebi, A. (1991). Cured Multiple Myeloma Followed by Primary Malignant Lymphoma of the Lung. Leukemia & lymphoma, 5(5), 441-5. https://doi.org/10.3109/10428199109067641
Schattner, A, et al. "Cured Multiple Myeloma Followed by Primary Malignant Lymphoma of the Lung." Leukemia & lymphoma vol. 5,5 (1991): 441-5. doi: https://doi.org/10.3109/10428199109067641
Schattner A, Nissim F, Berrebi A. Cured Multiple Myeloma Followed by Primary Malignant Lymphoma of the Lung. Leuk Lymphoma. 1991;5(5):441-5. doi: 10.3109/10428199109067641. PMID: 27463358.
Copy Download .nbib Format: NLM
Share it on

Leuk Lymphoma. 1991;5(5):441-5. doi: 10.3109/10428199109067641.

Cured Multiple Myeloma Followed by Primary Malignant Lymphoma of the Lung.

Leukemia & lymphoma

A Schattner, F Nissim, A Berrebi

Affiliations

  1. a Departments of Medicine 'A', Kaplan Hospital, Rehovot, affiliated to the Hebrew University and Hadassah Medical School Jerusalem, Israel.
  2. b Pathology, Kaplan Hospital, Rehovot, affiliated to the Hebrew University and Hadassah Medical School Jerusalem, Israel.
  3. c Hematology, Kaplan Hospital, Rehovot, affiliated to the Hebrew University and Hadassah Medical School Jerusalem, Israel.

PMID: 27463358 DOI: 10.3109/10428199109067641

Abstract

A 56-year-old patient was found to have smouldering myeloma which remained asymptomatic and untreated for 13 years. Localised osteolytic lesions then appeared, which responded to local irradiation. Six years later, an increased serum M-protein became evident (IgG$LD, 3 gr/dl) associated with 35% plasma cells in the bone marrow, which necessitated melphalan/prednisone therapy. A prolonged complete remission was achieved lasting 6 years. Thereafter, the patient developed a myelodysplastic syndrome with leukopenia and refractory anemia and he finally died of pulmonary disease. Autopsy revealed extensive thoracic involvement by a primary malignant lymphoma of the lungs (IgMK) with no evidence of myeloma. Such a long follow-up with subsequent cure is rare in multiple myeloma as is the appearance of a second B cell malignancy, which may either be associated with the myeloma and/or chemotherapy given, or a coincidental occurrence.

Keywords: Multiple myeloma; extranodal lymphoma; malignant lymphoma

Publication Types