Display options
Cite
Cho SK, Cho SK, Kim KH, et al. Effects of age on arterial stiffness and blood pressure variables in patients with newly diagnosed untreated hypertension. Korean Circ J. 2015;45(1):44-50doi: 10.4070/kcj.2015.45.1.44.
Cho, S. K., Cho, S. K., Kim, K. H., Cho, J. Y., Yoon, H. J., Yoon, N. S., Hong, Y. J., Park, H. W., Kim, J. H., Ahn, Y., Jeong, M. H., Cho, J. G., & Park, J. C. (2015). Effects of age on arterial stiffness and blood pressure variables in patients with newly diagnosed untreated hypertension. Korean circulation journal, 45(1), 44-50. https://doi.org/10.4070/kcj.2015.45.1.44
Cho, Soo Kyung, et al. "Effects of age on arterial stiffness and blood pressure variables in patients with newly diagnosed untreated hypertension." Korean circulation journal vol. 45,1 (2015): 44-50. doi: https://doi.org/10.4070/kcj.2015.45.1.44
Cho SK, Cho SK, Kim KH, Cho JY, Yoon HJ, Yoon NS, Hong YJ, Park HW, Kim JH, Ahn Y, Jeong MH, Cho JG, Park JC. Effects of age on arterial stiffness and blood pressure variables in patients with newly diagnosed untreated hypertension. Korean Circ J. 2015 Jan;45(1):44-50. doi: 10.4070/kcj.2015.45.1.44. Epub 2015 Jan 26. PMID: 25653703; PMCID: PMC4310979.
Copy Download .nbib Format: NLM
Share it on

Korean Circ J. 2015 Jan;45(1):44-50. doi: 10.4070/kcj.2015.45.1.44. Epub 2015 Jan 26.

Effects of age on arterial stiffness and blood pressure variables in patients with newly diagnosed untreated hypertension.

Korean circulation journal

Soo Kyung Cho, Sang Ki Cho, Kye Hun Kim, Jae Yeong Cho, Hyun Ju Yoon, Nam Sik Yoon, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park

Affiliations

  1. Department of Internal Medicine, Christian Hospital, Gwangju, Korea.
  2. Department of Cardiology, Translational Research Center on Aging, Chonnam National University Hospital, Gwangju, Korea.

PMID: 25653703 PMCID: PMC4310979 DOI: 10.4070/kcj.2015.45.1.44

Abstract

BACKGROUND AND OBJECTIVES: To investigate the impact of age on arterial stiffness and blood pressure (BP) variables in newly diagnosed untreated hypertension (HT).

SUBJECTS AND METHODS: A total of 144 patients with newly diagnosed untreated HT were divided into two groups: young group (age ≤50 years, n=71), and old group (age >50 years, n=73). BP variables were measured on office or 24 hours ambulatory BP monitoring (ABPM). Parameters of arterial stiffness were measured on pulse wave velocity (PWV). Pulse wave analysis (PWA) was compared.

RESULTS: Although office BP and pulse pressure (PP) were significantly (p<0.05) higher in the young group than in the old group, BP and PP on ABPM were not significantly different. Central systolic BP and PP, augmentation pressure, augmentation index on PWA, and PWV were significantly higher or faster in the old group compared to that in the young group. Age showed significant positive correlation with both PWV and PWA variables in the young group with HT. However, age only showed significant positive correlation with PWV in the old group with HT. In the young group with HT, PWA variable showed better correlation with age than PWV.

CONCLUSION: Considering BP levels on ABPM, office BP is prone to be overestimated in young patients with HT. Parameters of arterial stiffness measured by PWV and PWA were more affected by age rather than by BP level in patients with HT. Therefore, PWA variable might be a more sensitive marker of arterial stiffness in young patients with HT. However, PWV might be a better marker for old patients with HT.

Keywords: Aging; Hypertension; Vascular stiffness

References

  1. J Hum Hypertens. 1999 Feb;13(2):111-6 - PubMed
  2. JAMA. 1988 Jan 8;259(2):225-8 - PubMed
  3. Arterioscler Thromb Vasc Biol. 2001 Dec;21(12):2046-50 - PubMed
  4. Hypertension. 2007 Jul;50(1):154-60 - PubMed
  5. Am J Hypertens. 2001 Jul;14(7 Pt 1):649-52 - PubMed
  6. Korean Circ J. 2013 Feb;43(2):73-9 - PubMed
  7. Hypertension. 1997 Jan;29(1 Pt 1):30-9 - PubMed
  8. Circulation. 1999 May 11;99(18):2434-9 - PubMed
  9. Circulation. 2005 Apr 12;111(14):1777-83 - PubMed
  10. Hypertension. 2002 Jan;39(1):10-5 - PubMed
  11. Hypertension. 2005 Apr;45(4):592-6 - PubMed
  12. J Am Coll Cardiol. 2005 Nov 1;46(9):1753-60 - PubMed
  13. Circulation. 2006 Feb 7;113(5):664-70 - PubMed
  14. Hypertension. 2001 Oct;38(4):932-7 - PubMed
  15. Circulation. 2006 Mar 7;113(9):1213-25 - PubMed
  16. Blood Press Monit. 2004 Dec;9(6):307-9 - PubMed
  17. Circulation. 1988 Mar;77(3):504-14 - PubMed
  18. Lancet. 2003 Nov 8;362(9395):1527-35 - PubMed
  19. Acta Med Austriaca. 1994;21(3):86-9 - PubMed
  20. Hypertension. 2007 Jul;50(1):197-203 - PubMed
  21. Circulation. 2005 Jun 28;111(25):3384-90 - PubMed
  22. BMJ. 2012 Jan 13;344:e181 - PubMed
  23. Hypertension. 1998 Dec;32(6):983-8 - PubMed
  24. Clin Exp Hypertens. 2003 Oct;25(7):443-54 - PubMed
  25. Clin Cardiol. 1992 Oct;15(5 Suppl 2):II3-5 - PubMed
  26. Circulation. 2006 Feb 7;113(5):657-63 - PubMed
  27. J Hypertens. 1993 Nov;11(11):1289-97 - PubMed

Publication Types