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Viggiano E, Monda V, Messina A, et al. Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5. Neuropsychiatr Dis Treat. 2016;12:1705-10doi: 10.2147/NDT.S107074.
Viggiano, E., Monda, V., Messina, A., Moscatelli, F., Valenzano, A., Tafuri, D., Cibelli, G., De Luca, B., Messina, G., & Monda, M. (2016). Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5. Neuropsychiatric disease and treatment, 121705-10. https://doi.org/10.2147/NDT.S107074
Viggiano, Emanuela, et al. "Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5." Neuropsychiatric disease and treatment vol. 12 (2016): 1705-10. doi: https://doi.org/10.2147/NDT.S107074
Viggiano E, Monda V, Messina A, Moscatelli F, Valenzano A, Tafuri D, Cibelli G, De Luca B, Messina G, Monda M. Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5. Neuropsychiatr Dis Treat. 2016 Jul 11;12:1705-10. doi: 10.2147/NDT.S107074. eCollection 2016. PMID: 27468234; PMCID: PMC4946829.
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Neuropsychiatr Dis Treat. 2016 Jul 11;12:1705-10. doi: 10.2147/NDT.S107074. eCollection 2016.

Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5.

Neuropsychiatric disease and treatment

Emanuela Viggiano, Vincenzo Monda, Antonietta Messina, Fiorenzo Moscatelli, Anna Valenzano, Domenico Tafuri, Giuseppe Cibelli, Bruno De Luca, Giovanni Messina, Marcellino Monda

Affiliations

  1. Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, Second University of Naples, Naples; Department of Medicine, University of Padua, Padua.
  2. Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, Second University of Naples, Naples.
  3. Department of Clinical and Experimental Medicine, University of Foggia, Foggia.
  4. Department of Motor Sciences and Wellness, University of Naples "Parthenope", Naples, Italy.
  5. Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, Second University of Naples, Naples; Department of Clinical and Experimental Medicine, University of Foggia, Foggia.

PMID: 27468234 PMCID: PMC4946829 DOI: 10.2147/NDT.S107074

Abstract

Depression of electrocorticogram propagating over the cortex surface results in cortical spreading depression (CSD), which is probably related to the pathophysiology of stroke, epilepsy, and migraine. However, preconditioning with CSD produces neuroprotection to subsequent ischemic episodes. Such effects require the expression or activation of several genes, including neuroprotective ones. Recently, it has been demonstrated that the expression of the uncoupling proteins (UCPs) 2 and 5 is amplified during brain ischemia and their expression exerts a long-term effect upon neuron protection. To evaluate the neuroprotective consequence of CSD, the expression of UCP-5 in the brain cortex was measured following CSD induction. CSD was evoked in four samples of rats, which were sacrificed after 2 hours, 4 hours, 6 hours, and 24 hours. Western blot analyses were carried out to measure UCP-5 concentrations in the prefrontal cortices of both hemispheres, and immunohistochemistry was performed to determine the localization of UCP-5 in the brain cortex. The results showed a significant elevation in UCP-5 expression at 24 hours in all cortical strata. Moreover, UCP-5 was triggered by CSD, indicating that UCP-5 production can have a neuroprotective effect.

Keywords: cortical spreading depression; neuroprotective effect; uncoupling protein-5

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