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Bomberg H, Groesdonk HV, Bellgardt M, et al. AnaConDa™ and Mirus™ for intensive care sedation, 24 h desflurane versus isoflurane in one patient. Springerplus. 2016;5:420doi: 10.1186/s40064-016-2065-0.
Bomberg, H., Groesdonk, H. V., Bellgardt, M., Volk, T., & Meiser, A. (2016). AnaConDa™ and Mirus™ for intensive care sedation, 24 h desflurane versus isoflurane in one patient. SpringerPlus, 5420. https://doi.org/10.1186/s40064-016-2065-0
Bomberg, Hagen, et al. "AnaConDa™ and Mirus™ for intensive care sedation, 24 h desflurane versus isoflurane in one patient." SpringerPlus vol. 5 (2016): 420. doi: https://doi.org/10.1186/s40064-016-2065-0
Bomberg H, Groesdonk HV, Bellgardt M, Volk T, Meiser A. AnaConDa™ and Mirus™ for intensive care sedation, 24 h desflurane versus isoflurane in one patient. Springerplus. 2016 Apr 06;5:420. doi: 10.1186/s40064-016-2065-0. eCollection 2016. PMID: 27099825; PMCID: PMC4823227.
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Springerplus. 2016 Apr 06;5:420. doi: 10.1186/s40064-016-2065-0. eCollection 2016.

AnaConDa™ and Mirus™ for intensive care sedation, 24 h desflurane versus isoflurane in one patient.

SpringerPlus

Hagen Bomberg, Heinrich V Groesdonk, Martin Bellgardt, Thomas Volk, Andreas Meiser

Affiliations

  1. Department of Anaesthesiology, Intensive Care Medicine and Pain Medicine, Saarland University Medical Center, Kirrbergerstrasse 1, 66421 Homburg/Saar, Germany.
  2. Department of Anaesthesiology and Intensive Care Medicine, St. Josef Hospital, Katholisches Klinikum Bochum, Ruhr-University, Bochum, Germany.

PMID: 27099825 PMCID: PMC4823227 DOI: 10.1186/s40064-016-2065-0

Abstract

INTRODUCTION: With the AnaConDa™ system, inhalational sedation in the intensive care unit has become popular. The device can be used with common intensive care unit ventilators and is inserted between the Y-piece and the patient. Liquid isoflurane or sevoflurane are delivered by a syringe pump. 90 % of anesthetic exhaled by the patient is absorbed by a reflector and resupplied during the next inspiration. The new Mirus™ system also uses a reflector. Its control unit identifies end-tidal concentrations from the flow, injects anesthetics during early inspiration, controls anesthetic concentrations automatically, and can also apply desflurane. The AnaConDa™ and Mirus™ system are certified 'conformité établi', however, little is known about the Mirus™ and case reports are still lacking.

CASE DESCRIPTION: We used the Mirus™ with desflurane for 24 h in a patient suffering from acute respiratory distress syndrome. The patient was treated with kinetic lateral rotational therapy. While deeply sedated, our patient breathed 9.0-12.0 l min(-1) spontaneously. Thereafter, awakening and wash-out were considerably shorter than after isoflurane in the same patient with AnaConDa™. There were no major problems during the sedation. However, consumption of desflurane was high.

CONCLUSION: Desflurane sedation with the Mirus™ seems promising, but the reflector should be improved to absorb and resupply more of the anesthetic agent.

Keywords: AnaConDa™; Desflurane; Intensive care unit (ICU); Mirus™; Sedation

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