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Ali N, Pickens PV, Auerbach HE. Immunoglobulin D Multiple Myeloma, Plasma Cell Leukemia and Chronic Myelogenous Leukemia in a Single Patient Treated Simultaneously with Lenalidomide, Bortezomib, Dexamethasone and Imatinib. Hematol Rep. 2016;8(1):6295doi: 10.4081/hr.2016.6295.
Ali, N., Pickens, P. V., & Auerbach, H. E. (2016). Immunoglobulin D Multiple Myeloma, Plasma Cell Leukemia and Chronic Myelogenous Leukemia in a Single Patient Treated Simultaneously with Lenalidomide, Bortezomib, Dexamethasone and Imatinib. Hematology reports, 8(1), 6295. https://doi.org/10.4081/hr.2016.6295
Ali, Naveed, et al. "Immunoglobulin D Multiple Myeloma, Plasma Cell Leukemia and Chronic Myelogenous Leukemia in a Single Patient Treated Simultaneously with Lenalidomide, Bortezomib, Dexamethasone and Imatinib." Hematology reports vol. 8,1 (2016): 6295. doi: https://doi.org/10.4081/hr.2016.6295
Ali N, Pickens PV, Auerbach HE. Immunoglobulin D Multiple Myeloma, Plasma Cell Leukemia and Chronic Myelogenous Leukemia in a Single Patient Treated Simultaneously with Lenalidomide, Bortezomib, Dexamethasone and Imatinib. Hematol Rep. 2016 Mar 17;8(1):6295. doi: 10.4081/hr.2016.6295. eCollection 2016 Mar 17. PMID: 27103978; PMCID: PMC4815947.
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Hematol Rep. 2016 Mar 17;8(1):6295. doi: 10.4081/hr.2016.6295. eCollection 2016 Mar 17.

Immunoglobulin D Multiple Myeloma, Plasma Cell Leukemia and Chronic Myelogenous Leukemia in a Single Patient Treated Simultaneously with Lenalidomide, Bortezomib, Dexamethasone and Imatinib.

Hematology reports

Naveed Ali, Peter V Pickens, Herbert E Auerbach

Affiliations

  1. Departments of Internal Medicine, Abington Memorial Hospital/Abington-Jefferson Health , PA, USA.
  2. Departments of Hematology and Oncology, Abington Memorial Hospital/Abington-Jefferson Health , PA, USA.
  3. Departments of Pathology, Abington Memorial Hospital/Abington-Jefferson Health , PA, USA.

PMID: 27103978 PMCID: PMC4815947 DOI: 10.4081/hr.2016.6295

Abstract

Multiple myeloma (MM) is a neoplastic lymphoproliferative disorder characterized by uncontrolled monoclonal plasma cell proliferation. Among different isotypes of MM, immunoglobulin D (IgD) MM is very rare, representing only 1 to 2% of all isotypes. Chronic myelogenous leukemia (CML) is a neoplastic myeloproliferative disorder of pluripotent hematopoietic stem cell, which is characterized by the uncontrolled proliferation of myeloid cells. An 88-year-old male was diagnosed simultaneously with IgD kappa MM and CML. A distinctive feature in this patient was the progression to plasma cell leukemia without any symptomatic myeloma stage. He was treated simultaneously with lenalidomide, bortezomib and imatinib. Synchronous occurrence of these rare hematological malignancies in a single patient is an exceedingly rare event. Multiple hypotheses to explain co-occurrence of CML and MM have been proposed; however, the exact etiological molecular pathophysiology remains elusive.

Keywords: Immunoglobulin D multiple myeloma; bortezomib; chronic myelogenous leukemia; imatinib; plasma cell leukemia

References

  1. N Engl J Med. 2011 Mar 17;364(11):1046-60 - PubMed
  2. Oncologist. 2009 Dec;14(12):1198-200 - PubMed
  3. Leukemia. 2013 Apr;27(4):780-91 - PubMed
  4. Oncology (Williston Park). 2013 Aug;27(8):798-803 - PubMed
  5. Int J Hematol. 2010 May;91(4):699-704 - PubMed
  6. Clin Lymphoma Myeloma Leuk. 2013 Apr;13(2):175-9 - PubMed
  7. Haematologica. 2001 Aug;86(8):894 - PubMed
  8. Oncologist. 2005 Jun-Jul;10(6):457-8 - PubMed
  9. Blood. 2012 Mar 22;119(12):2731-7 - PubMed
  10. N Engl J Med. 1999 Apr 29;340(17):1330-40 - PubMed
  11. Ann Hematol. 2009 Mar;88(3):281-2 - PubMed
  12. Case Rep Oncol Med. 2014;2014:962526 - PubMed
  13. Blood. 2012 Sep 20;120(12):2376-89 - PubMed
  14. Leukemia. 2003 Jul;17(7):1426-8 - PubMed
  15. N Engl J Med. 2003 Oct 9;349(15):1451-64 - PubMed
  16. Int J Hematol. 2012 Apr;95(4):451-2 - PubMed
  17. Case Rep Hematol. 2014;2014:738428 - PubMed
  18. Lancet Oncol. 2014 Nov;15(12):e538-48 - PubMed

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