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Diagnostics (Basel). 2016 Sep 02;6(3). doi: 10.3390/diagnostics6030032.

Clinical Utility and Future Applications of PET/CT and PET/CMR in Cardiology.

Diagnostics (Basel, Switzerland)

Jonathan A Pan, Michael Salerno

Affiliations

  1. Departments of Medicine Cardiology Division, University of Virginia Health System, Charlottesville, VA 22903, USA. [email protected].
  2. Departments of Medicine Cardiology Division, University of Virginia Health System, Charlottesville, VA 22903, USA. [email protected].
  3. Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903, USA. [email protected].
  4. Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22903, USA. [email protected].

PMID: 27598207 PMCID: PMC5039566 DOI: 10.3390/diagnostics6030032

Abstract

Over the past several years, there have been major advances in cardiovascular positron emission tomography (PET) in combination with either computed tomography (CT) or, more recently, cardiovascular magnetic resonance (CMR). These multi-modality approaches have significant potential to leverage the strengths of each modality to improve the characterization of a variety of cardiovascular diseases and to predict clinical outcomes. This review will discuss current developments and potential future uses of PET/CT and PET/CMR for cardiovascular applications, which promise to add significant incremental benefits to the data provided by each modality alone.

Keywords: PET/CMR; PET/CT; cardiovascular magnetic resonance; computed tomography; molecular imaging; myocardial; positron emission tomography

Conflict of interest statement

The authors declare no conflict of interest.

References

  1. JACC Cardiovasc Imaging. 2009 Jul;2(7):846-54 - PubMed
  2. JACC Cardiovasc Imaging. 2016 Jan;9(1):67-81 - PubMed
  3. Circulation. 2003 Feb 25;107(7):1046-52 - PubMed
  4. J Nucl Med. 2007 Jul;48(7):1135-46 - PubMed
  5. J Nucl Med. 2011 Dec;52(12 ):1914-22 - PubMed
  6. Nucl Med Biol. 2015 Nov;42(11):858-63 - PubMed
  7. Circulation. 1995 Sep 15;92(6):1565-9 - PubMed
  8. Circulation. 1996 Nov 15;94(10 ):2455-64 - PubMed
  9. J Am Coll Cardiol. 2012 Oct 16;60(16):1546-55 - PubMed
  10. Eur J Nucl Med Mol Imaging. 2012 Apr;39(4):683-92 - PubMed
  11. J Nucl Cardiol. 2008 Nov-Dec;15(6):745-53 - PubMed
  12. J Nucl Med. 2007 May;48(5):783-93 - PubMed
  13. Diagn Interv Radiol. 2014 Sep-Oct;20(5):438-47 - PubMed
  14. Acad Radiol. 2004 Mar;11(3):316-21 - PubMed
  15. Heart. 1999 Mar;81(3):262-70 - PubMed
  16. J Nucl Med. 2011 May;52(5):726-32 - PubMed
  17. J Nucl Med. 2012 Feb;53(2):318-23 - PubMed
  18. JACC Cardiovasc Imaging. 2013 Jul;6(7):806-22 - PubMed
  19. JACC Cardiovasc Imaging. 2010 Feb;3(2):155-64 - PubMed
  20. Eur J Nucl Med Mol Imaging. 2012 Jan;39(1):102-12 - PubMed
  21. J Nucl Cardiol. 2010 Dec;17 (6):1023-33 - PubMed
  22. J Nucl Cardiol. 2013 Oct;20(5):874-90 - PubMed
  23. J Nucl Med. 2006 Jan;47(1):59-67 - PubMed
  24. J Am Coll Cardiol. 2002 Nov 20;40(10 ):1735-43 - PubMed
  25. Curr Cardiol Rep. 2013 Apr;15(4):352 - PubMed
  26. Appl Radiat Isot. 2011 Jun;69(6):862-8 - PubMed
  27. Curr Cardiol Rep. 2012 Apr;14 (2):226-33 - PubMed
  28. Circulation. 1995 Oct 15;92 (8):2157-62 - PubMed
  29. J Cardiovasc Magn Reson. 2010 Nov 30;12:71 - PubMed
  30. Eur J Nucl Med Mol Imaging. 2013 Dec;40(12 ):1894-904 - PubMed
  31. IEEE Nucl Sci Symp Conf Rec (1997). 2014 Nov;2014:null - PubMed
  32. J Nucl Med. 2012 Jun;53(6):856-63 - PubMed
  33. Eur J Nucl Med Mol Imaging. 2009 Mar;36 Suppl 1:S86-92 - PubMed
  34. Radiology. 2013 Aug;268(2):366-73 - PubMed
  35. J Nucl Cardiol. 2015 Jun;22(3):468-79 - PubMed
  36. Appl Radiat Isot. 2009 Apr;67(4):606-10 - PubMed
  37. Circulation. 2002 Jan 15;105(2):162-7 - PubMed
  38. MAGMA. 2013 Feb;26(1):25-35 - PubMed
  39. Biochem Biophys Res Commun. 2015 Jan 2;456(1):13-9 - PubMed
  40. J Nucl Cardiol. 2013 Feb;20(1):150-65 - PubMed
  41. J Nucl Med. 2009 Apr;50(4):563-8 - PubMed
  42. AJR Am J Roentgenol. 2008 Feb;190(2):W151-6 - PubMed
  43. Phys Med Biol. 2014 Mar 7;59(5):1203-22 - PubMed
  44. Eur Heart J Cardiovasc Imaging. 2014 Feb;15(2):216-25 - PubMed
  45. JACC Cardiovasc Imaging. 2014 Feb;7(2):157-65 - PubMed
  46. J Nucl Cardiol. 2007 Nov-Dec;14 (6):782-8 - PubMed
  47. Eur J Nucl Med Mol Imaging. 2009 Dec;36(12 ):2027-33 - PubMed
  48. Circulation. 1985 Dec;72(6 Pt 2):V123-35 - PubMed
  49. J Am Coll Cardiol. 2013 Jan 29;61(4):469-77 - PubMed
  50. J Comput Assist Tomogr. 1989 Jan-Feb;13(1):20-6 - PubMed
  51. J Am Coll Cardiol. 2009 Jul 7;54(2):150-6 - PubMed
  52. J Cardiovasc Magn Reson. 2011 Feb 18;13:13 - PubMed
  53. Semin Nucl Med. 2013 Jan;43(1):19-29 - PubMed
  54. J Nucl Med. 2012 Aug;53(8):1230-4 - PubMed
  55. Eur J Nucl Med Mol Imaging. 2014 Aug;41(8):1617-23 - PubMed
  56. J Am Coll Cardiol. 2003 Apr 16;41(8):1341-8 - PubMed
  57. J Nucl Med. 2007 Mar;48(3):349-58 - PubMed
  58. Nat Rev Cardiol. 2014 Aug;11(8):443-57 - PubMed
  59. Diagn Interv Radiol. 2015 Jan-Feb;21(1):28-33 - PubMed
  60. Circulation. 2012 Sep 4;126(10):1206-16 - PubMed
  61. Eur J Nucl Med Mol Imaging. 2011 Sep;38(9):1691-701 - PubMed
  62. Expert Rev Mol Med. 2016 Apr 08;18:e6 - PubMed
  63. Circulation. 1995 Dec 15;92 (12 ):3436-44 - PubMed
  64. Circ Cardiovasc Imaging. 2009 Mar;2(2):77-84 - PubMed
  65. Lancet. 2014 Feb 22;383(9918):705-13 - PubMed
  66. Cardiovasc Res. 2008 May 1;78(2):395-403 - PubMed
  67. Circulation. 2009 May 5;119(17):2333-42 - PubMed
  68. J Nucl Med. 2007 Jul;48(7):1112-21 - PubMed
  69. J Nucl Med. 2004 Dec;45(12 ):1989-98 - PubMed
  70. J Nucl Med. 1996 Oct;37(10 ):1701-12 - PubMed
  71. Phys Med Biol. 2011 May 21;56(10):3091-106 - PubMed
  72. Eur J Nucl Med Mol Imaging. 2007 Jun;34 Suppl 1:S1-8 - PubMed
  73. J Nucl Med. 2012 Apr;53(4):575-83 - PubMed
  74. Circ Cardiovasc Imaging. 2012 Jul;5(4):481-90 - PubMed
  75. J Nucl Med. 2013 Jan;54(1):55-63 - PubMed
  76. Circ Cardiovasc Imaging. 2016 Jan;9(1):e003738 - PubMed
  77. Curr Probl Cardiol. 2007 Jul;32(7):375-410 - PubMed
  78. Circulation. 2009 Sep 29;120(13):1203-12 - PubMed
  79. J Cardiol. 2010 Mar;55(2):163-73 - PubMed
  80. Circulation. 1990 Aug;82(2):457-64 - PubMed
  81. J Am Coll Cardiol. 2013 Jan 15;61(2):176-84 - PubMed
  82. J Nucl Med. 2014 Oct;55(10 ):1629-35 - PubMed
  83. Eur Heart J. 2013 Aug;34(30):2354-61 - PubMed
  84. Eur J Radiol. 2014 Jul;83(7):1120-8 - PubMed
  85. Am J Cardiol. 2015 Nov 1;116(9):1469-78 - PubMed
  86. J Nucl Med. 2010 Mar;51(3):333-6 - PubMed
  87. AJR Am J Roentgenol. 2013 Aug;201(2):W245-52 - PubMed
  88. J Am Coll Cardiol. 2006 Sep 5;48(5):1029-39 - PubMed
  89. J Nucl Med. 2007 Feb;48(2):175-81 - PubMed
  90. J Nucl Cardiol. 2008 Sep-Oct;15(5):719-26 - PubMed
  91. J Nucl Med. 1990 Aug;31(8):1328-34 - PubMed
  92. J Am Coll Cardiol. 2005 May 3;45(9):1505-12 - PubMed
  93. Circ Cardiovasc Imaging. 2009 Sep;2(5):412-24 - PubMed
  94. J Am Coll Cardiol. 1993 Aug;22(2):368-75 - PubMed
  95. Can J Cardiol. 2006 Feb;22 Suppl B:25B-30B - PubMed
  96. JACC Cardiovasc Imaging. 2010 Apr;3(4):388-97 - PubMed
  97. JACC Cardiovasc Imaging. 2014 Feb;7(2):143-56 - PubMed
  98. Cardiol Clin. 2016 Feb;34(1):13-23 - PubMed
  99. Atherosclerosis. 2013 Jul;229(1):34-7 - PubMed
  100. J Mol Cell Cardiol. 2001 Mar;33(3):461-72 - PubMed
  101. Circ Cardiovasc Imaging. 2011 Nov;4(6):678-84 - PubMed
  102. Eur J Nucl Med Mol Imaging. 2013 Jul;40(7):1102-7 - PubMed
  103. J Nucl Med. 2015 Sep;56(9):1345-50 - PubMed
  104. Am Heart J. 1978 Feb;95(2):204-9 - PubMed
  105. JACC Cardiovasc Imaging. 2013 Apr;6(4):488-97 - PubMed
  106. J Am Coll Cardiol. 2012 May 8;59(19):1719-28 - PubMed
  107. J Nucl Med. 2014 Jan;55(1):99-106 - PubMed
  108. J Nucl Cardiol. 2007 Nov-Dec;14(6):789-98 - PubMed
  109. J Am Coll Cardiol. 2002 Feb 6;39(3):420-7 - PubMed
  110. Bioorg Med Chem. 2016 Feb 15;24(4):902-9 - PubMed
  111. J Nucl Cardiol. 2004 Jul-Aug;11(4):440-9 - PubMed
  112. Rofo. 2002 Jul;174(7):867-73 - PubMed
  113. Circulation. 1996 Aug 15;94(4):660-6 - PubMed
  114. Eur Heart J Cardiovasc Imaging. 2015 Jun;16(6):661-9 - PubMed
  115. Atherosclerosis. 2013 Jul;229(1):124-9 - PubMed
  116. Circ Cardiovasc Imaging. 2014 Mar;7(2):282-91 - PubMed
  117. Br Med Bull. 2015 Sep;115(1):151-63 - PubMed
  118. J Nucl Med. 2008 Apr;49(4):630-6 - PubMed
  119. Eur J Nucl Med Mol Imaging. 2014 Sep;41(9):1652-62 - PubMed
  120. Heart Fail Rev. 2015 Mar;20(2):133-44 - PubMed
  121. J Am Coll Cardiol. 2011 Aug 9;58(7):740-8 - PubMed
  122. Neth Heart J. 2010 Feb;18(2):90-8 - PubMed
  123. Atherosclerosis. 2013 Jun;228(2):339-45 - PubMed
  124. Phys Med Biol. 2015 Feb 21;60(4):R115-54 - PubMed
  125. Acad Radiol. 2008 Apr;15(4):444-51 - PubMed
  126. Eur J Nucl Med. 2001 Mar;28(3):373-6 - PubMed
  127. J Nucl Med Technol. 2009 Dec;37(4):215-9 - PubMed
  128. Circ Cardiovasc Imaging. 2016 Mar;9(3):e003900 - PubMed
  129. Radiology. 2015 Nov;277(2):388-97 - PubMed
  130. Circulation. 2009 Nov 17;120(20):1969-77 - PubMed
  131. Circulation. 2010 Aug 10;122(6):603-13 - PubMed
  132. Circulation. 1981 Jun;63(6):1259-72 - PubMed
  133. Radiology. 2002 May;223(2):474-80 - PubMed
  134. J Am Coll Cardiol. 2014 Jan 21;63(2):141-9 - PubMed
  135. J Cardiovasc Magn Reson. 2014 Feb 24;16:19 - PubMed
  136. AJR Am J Roentgenol. 2009 Jan;192(1):235-43 - PubMed
  137. Circulation. 2008 Apr 1;117(13):1693-700 - PubMed
  138. J Nucl Med. 2013 Aug;54(8):1485-507 - PubMed
  139. Radiology. 2013 Apr;267(1):26-44 - PubMed
  140. Am J Physiol. 1987 Apr;252(4 Pt 2):H777-87 - PubMed
  141. J Nucl Med. 2011 Sep;52(9):1392-9 - PubMed
  142. J Am Coll Cardiol. 2013 Jun 11;61(23 ):2374-82 - PubMed
  143. Am J Respir Crit Care Med. 2014 Jan 1;189(1):109-12 - PubMed
  144. J Nucl Cardiol. 2013 Dec;20(6):976-89 - PubMed
  145. J Nucl Cardiol. 2010 Jan-Feb;17(1):45-51 - PubMed
  146. Eur Heart J. 2014 Mar;35(10):624-32 - PubMed
  147. Circ Res. 2013 Jun 21;113(1):72-7 - PubMed
  148. J Am Coll Cardiol. 2014 Sep 23;64(12):1217-26 - PubMed
  149. J Nucl Med. 2007 Feb;48(2):188-93 - PubMed
  150. J Nucl Med. 2008 Nov;49(11):1875-83 - PubMed
  151. J Comput Assist Tomogr. 1993 Jul-Aug;17 (4):536-46 - PubMed
  152. J Cardiovasc Magn Reson. 2015 Aug 01;17:68 - PubMed
  153. J Nucl Cardiol. 2012 Aug;19(4):670-80 - PubMed
  154. Circulation. 2007 Dec 11;116(24):2841-50 - PubMed
  155. J Cardiovasc Pharmacol Ther. 2011 Sep-Dec;16(3-4):313-20 - PubMed
  156. Biomed Res Int. 2014;2014:504532 - PubMed
  157. N Engl J Med. 2000 Nov 16;343(20):1445-53 - PubMed

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