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Capurso G, Signoretti M, Archibugi L, et al. Systematic review and meta-analysis: Small intestinal bacterial overgrowth in chronic pancreatitis. United European Gastroenterol J. 2016;4(5):697-705doi: 10.1177/2050640616630117.
Capurso, G., Signoretti, M., Archibugi, L., Stigliano, S., & Delle Fave, G. (2016). Systematic review and meta-analysis: Small intestinal bacterial overgrowth in chronic pancreatitis. United European gastroenterology journal, 4(5), 697-705. https://doi.org/10.1177/2050640616630117
Capurso, Gabriele, et al. "Systematic review and meta-analysis: Small intestinal bacterial overgrowth in chronic pancreatitis." United European gastroenterology journal vol. 4,5 (2016): 697-705. doi: https://doi.org/10.1177/2050640616630117
Capurso G, Signoretti M, Archibugi L, Stigliano S, Delle Fave G. Systematic review and meta-analysis: Small intestinal bacterial overgrowth in chronic pancreatitis. United European Gastroenterol J. 2016 Oct;4(5):697-705. doi: 10.1177/2050640616630117. Epub 2016 Feb 03. PMID: 27733912; PMCID: PMC5042309.
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United European Gastroenterol J. 2016 Oct;4(5):697-705. doi: 10.1177/2050640616630117. Epub 2016 Feb 03.

Systematic review and meta-analysis: Small intestinal bacterial overgrowth in chronic pancreatitis.

United European gastroenterology journal

Gabriele Capurso, Marianna Signoretti, Livia Archibugi, Serena Stigliano, Gianfranco Delle Fave

Affiliations

  1. Digestive and Liver Disease Unit, S. Andrea Hospital, Rome, Italy.

PMID: 27733912 PMCID: PMC5042309 DOI: 10.1177/2050640616630117

Abstract

BACKGROUND: Evidence on small intestinal bacterial overgrowth (SIBO) in patients with chronic pancreatitis (CP) is conflicting.

AIM: The purpose of this study was to perform a systematic review and meta-analysis on the prevalence of SIBO in CP and to examine the relationship of SIBO with symptoms and nutritional status.

METHODS: Case-control and cross-sectional studies investigating SIBO in CP patients were analysed. The prevalence of positive tests was pooled across studies, and the rate of positivity between CP cases and controls was calculated.

RESULTS: In nine studies containing 336 CP patients, the pooled prevalence of SIBO was 36% (95% confidence interval (CI) 17-60%) with considerable heterogeneity (

CONCLUSIONS: One-third of CP patients have SIBO, with a significantly increased risk over controls, although results are heterogeneous, and studies carry several limitations. The impact of SIBO and its treatment in CP patients deserve further investigation.

Keywords: Chronic pancreatitis; nutrition; pancreatic exocrine insufficiency; small intestinal bacterial overgrowth; symptoms

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