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Sebastian S, Filmalter C, Harvey J, et al. Intradialytic hypertension during chronic haemodialysis and subclinical fluid overload assessed by bioimpedance spectroscopy. Clin Kidney J. 2016;9(4):636-43doi: 10.1093/ckj/sfw052.
Sebastian, S., Filmalter, C., Harvey, J., & Chothia, M. Y. (2016). Intradialytic hypertension during chronic haemodialysis and subclinical fluid overload assessed by bioimpedance spectroscopy. Clinical kidney journal, 9(4), 636-43. https://doi.org/10.1093/ckj/sfw052
Sebastian, Sajith, et al. "Intradialytic hypertension during chronic haemodialysis and subclinical fluid overload assessed by bioimpedance spectroscopy." Clinical kidney journal vol. 9,4 (2016): 636-43. doi: https://doi.org/10.1093/ckj/sfw052
Sebastian S, Filmalter C, Harvey J, Chothia MY. Intradialytic hypertension during chronic haemodialysis and subclinical fluid overload assessed by bioimpedance spectroscopy. Clin Kidney J. 2016 Aug;9(4):636-43. doi: 10.1093/ckj/sfw052. Epub 2016 Jun 19. PMID: 27478611; PMCID: PMC4957728.
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Clin Kidney J. 2016 Aug;9(4):636-43. doi: 10.1093/ckj/sfw052. Epub 2016 Jun 19.

Intradialytic hypertension during chronic haemodialysis and subclinical fluid overload assessed by bioimpedance spectroscopy.

Clinical kidney journal

Sajith Sebastian, Christelle Filmalter, Justin Harvey, Mogamat-Yazied Chothia

Affiliations

  1. Department of Medicine, Division of General Medicine and Nephrology, Faculty of Medicine and Health Sciences , Stellenbosch University, and Tygerberg Academic Hospital , Francie van Zijl Drive, Parow Valley , Stellenbosch , Cape Town, South Africa.
  2. Central University of Technology , Bloemfontein , South Africa.
  3. Centre for Statistical Consultation, Stellenbosch University , Stellenbosch , South Africa.

PMID: 27478611 PMCID: PMC4957728 DOI: 10.1093/ckj/sfw052

Abstract

BACKGROUND: Intradialytic hypertension (IDH) increases morbidity and mortality. The prevalence in South Africa is unknown. The pathogenesis is unclear, but it has been suggested that IDH may be due to subclinical fluid overload. The objective of this study was to determine the prevalence of IDH and to evaluate its association with fluid overload using bioimpedance spectroscopy (BIS).

METHODS: A cross-sectional study involving 190 chronic haemodialysis patients in the Western Cape province of South Africa was conducted between January 2013 and May 2014. IDH was defined as a >10 mmHg increase in systolic blood pressure in at least four of six prior consecutive haemodialysis sessions.

RESULTS: The prevalence of IDH was 28.4% (n = 54). There was a trend towards pre-dialysis overhydration in the IDH group when compared with controls {2.6 L [95% confidence interval (CI) 1.7-3.4] versus 1.8 L [95% CI 1.4-2.1], respectively; P = 0.06} as measured by BIS, but no difference in mean ultrafiltration (UF) volume (2.4 versus 2.6 L; P = 0.30). A trend towards greater use of antihypertensive drugs was noted in the IDH group [2.5 drugs (95% CI 2.15-2.87) versus 2.1 (95% CI 1.82-2.30); P = 0.05]. More participants in the IDH group received calcium channel blockers (54 versus 36; P = 0.03).

CONCLUSIONS: The prevalence of IDH in our treatment centres is much higher than previously reported. Subclinical fluid overload may be a major contributing factor to the mechanism of this condition. The use of BIS identifies patients who may benefit from additional UF.

Keywords: bioimpedance monitoring; haemodialysis; intradialytic hypertension

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