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Harada M, Takeshima T, Okayama M, et al. Differences in genotype frequencies of salt-sensitive genes between fishing and nonfishing communities in Japan. Int J Gen Med. 2016;9:73-8doi: 10.2147/IJGM.S93148.
Harada, M., Takeshima, T., Okayama, M., & Kajii, E. (2016). Differences in genotype frequencies of salt-sensitive genes between fishing and nonfishing communities in Japan. International journal of general medicine, 973-8. https://doi.org/10.2147/IJGM.S93148
Harada, Masanori, et al. "Differences in genotype frequencies of salt-sensitive genes between fishing and nonfishing communities in Japan." International journal of general medicine vol. 9 (2016): 73-8. doi: https://doi.org/10.2147/IJGM.S93148
Harada M, Takeshima T, Okayama M, Kajii E. Differences in genotype frequencies of salt-sensitive genes between fishing and nonfishing communities in Japan. Int J Gen Med. 2016 Apr 12;9:73-8. doi: 10.2147/IJGM.S93148. eCollection 2016. PMID: 27110136; PMCID: PMC4835121.
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Int J Gen Med. 2016 Apr 12;9:73-8. doi: 10.2147/IJGM.S93148. eCollection 2016.

Differences in genotype frequencies of salt-sensitive genes between fishing and nonfishing communities in Japan.

International journal of general medicine

Masanori Harada, Taro Takeshima, Masanobu Okayama, Eiji Kajii

Affiliations

  1. Department for Support of Rural Health Care, Yamaguchi Grand Medical Center, Hofu, Yamaguchi, Japan.
  2. Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Shimotsuke, Japan.
  3. Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Shimotsuke, Japan; Division of Community Medicine and Medical Education, Kobe University Graduate School of Medicine, Kobe, Japan.

PMID: 27110136 PMCID: PMC4835121 DOI: 10.2147/IJGM.S93148

Abstract

PURPOSE: To identify the differences in genotype frequencies of salt-sensitive genes between residents of fishing communities (FCs) and nonfishing communities (NFCs).

METHODS: The subjects included 18,156 individuals (8,043 males [44%] and 10,113 females [56%]; average age: 57.2±16.1 years) from the general population who were registered with large-scale genome banks and resided in 30 prefectures and 78 different regions in Japan. The measurement items were age, sex, blood pressure, presence or absence of hypertension, body mass index, alcohol consumption, and smoking habit. Furthermore, to analyze the genotype frequencies of salt-sensitive genes, α-adducin 1 (ADD1), angiotensinogen (AGT), angiotensin II receptor type 1 (AT1), and guanine nucleotide-binding protein β peptide 3 (GNB3) were measured. According to the 2004 government classification of municipalities (cities, towns, and villages), communities existing in areas bordering an ocean and with an ocean port were defined as FCs (28 areas). The others were defined as NFCs (50 areas). A logistic regression model was used for comparison of genotype frequencies between subjects residing in FCs and NFCs.

RESULTS: Of the included subjects, 4,916 (27.0%) and 13,240 (73.0%) resided in FCs and NFCs, respectively. In FCs, the mean age was 59.4±16.7 years and men accounted for 41.0% of the cohort (n=2,015). In NFCs, the mean age was 56.4±15.8 years and men accounted for 45.5% of the cohort (n=6,028). The adjusted odds ratios of the AA and AG genotypes compared with the GG genotype for AGT were 0.80 (95% confidence interval [CI]: 0.68-0.95) and 0.76 (95% CI: 0.64-0.91), respectively. The adjusted odds ratio of the CC genotype compared with AA for AT1 was 0.63 (95% CI: 0.40-0.93).

CONCLUSION: The incidence of the salt-sensitive genotypes AGT and AT1 in residents of FCs were significantly lower than in NFCs.

Keywords: behavior; hypertension; lifestyle; regional difference; salt-sensitive; single-nucleotide polymorphisms

References

  1. JAMA. 2003 May 14;289(18):2363-9 - PubMed
  2. Lancet. 2005 Jan 15-21;365(9455):217-23 - PubMed
  3. Circulation. 1997 Aug 19;96(4):1082-8 - PubMed
  4. Hypertension. 1986 Jun;8(6 Pt 2):II127-34 - PubMed
  5. Genet Mol Res. 2015 May 25;14(2):5527-34 - PubMed
  6. Hypertens Res. 2003 Jul;26(7):521-5 - PubMed
  7. Hypertension. 1999 Feb;33(2):694-7 - PubMed
  8. Am J Hypertens. 2011 Apr;24(4):437-43 - PubMed
  9. Hypertension. 2004 Jun;43(6):1332-7 - PubMed
  10. Appl Environ Microbiol. 2012 Feb;78(4):1063-8 - PubMed
  11. Ann N Y Acad Sci. 1997 Apr 15;811:412-9 - PubMed
  12. Hypertens Res. 2002 May;25(3):319-27 - PubMed
  13. Cell. 1992 Oct 2;71(1):169-80 - PubMed
  14. J Nutr Sci Vitaminol (Tokyo). 1985 Aug;31(4):417-22 - PubMed
  15. Lancet. 2006 May 27;367(9524):1747-57 - PubMed
  16. Circulation. 2008 Dec 16;118(25):2702-9 - PubMed
  17. J Hum Hypertens. 2000 Oct-Nov;14(10-11):765-9 - PubMed
  18. Nat Genet. 1998 Jan;18(1):45-8 - PubMed
  19. Hypertension. 2007 Mar;49(3):631-9 - PubMed
  20. Hypertension. 2000 Jan;35(1 Pt 2):512-7 - PubMed
  21. Hypertension. 1994 Jul;24(1):63-9 - PubMed
  22. J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):898-909 - PubMed
  23. Lancet. 2008 May 3;371(9623):1513-8 - PubMed
  24. Clin Sci (Lond). 1996 Aug;91(2):155-61 - PubMed
  25. Atherosclerosis. 2000 Dec;153(2):469-81 - PubMed
  26. Am J Kidney Dis. 1990 Oct;16(4 Suppl 1):35-40 - PubMed
  27. Lancet. 2002 Nov 2;360(9343):1347-60 - PubMed
  28. Hypertension. 2008 Mar;51(3):778-83 - PubMed
  29. J Hypertens. 2007 Jan;25(1):73-9 - PubMed
  30. J Intern Med Suppl. 1989;731:69-75 - PubMed

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