Display options
Cite
Pepke W, Kasten P, Beckmann NA, et al. Core Decompression and Autologous Bone Marrow Concentrate for Treatment of Femoral Head Osteonecrosis: A Randomized Prospective Study. Orthop Rev (Pavia). 2016;8(1):6162doi: 10.4081/or.2016.6162.
Pepke, W., Kasten, P., Beckmann, N. A., Janicki, P., & Egermann, M. (2016). Core Decompression and Autologous Bone Marrow Concentrate for Treatment of Femoral Head Osteonecrosis: A Randomized Prospective Study. Orthopedic reviews, 8(1), 6162. https://doi.org/10.4081/or.2016.6162
Pepke, Wojciech, et al. "Core Decompression and Autologous Bone Marrow Concentrate for Treatment of Femoral Head Osteonecrosis: A Randomized Prospective Study." Orthopedic reviews vol. 8,1 (2016): 6162. doi: https://doi.org/10.4081/or.2016.6162
Pepke W, Kasten P, Beckmann NA, Janicki P, Egermann M. Core Decompression and Autologous Bone Marrow Concentrate for Treatment of Femoral Head Osteonecrosis: A Randomized Prospective Study. Orthop Rev (Pavia). 2016 Mar 21;8(1):6162. doi: 10.4081/or.2016.6162. eCollection 2016 Mar 21. PMID: 27114808; PMCID: PMC4821226.
Copy Download .nbib Format: NLM
Share it on

Orthop Rev (Pavia). 2016 Mar 21;8(1):6162. doi: 10.4081/or.2016.6162. eCollection 2016 Mar 21.

Core Decompression and Autologous Bone Marrow Concentrate for Treatment of Femoral Head Osteonecrosis: A Randomized Prospective Study.

Orthopedic reviews

Wojciech Pepke, Philip Kasten, Nicholas A Beckmann, Patricia Janicki, Marcus Egermann

Affiliations

  1. Clinic for Orthopedics and Trauma Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital , Germany.
  2. Orthopedic Surgery Center , Tübingen, Germany.
  3. Clinic for Orthopedics and Trauma Surgery, St. Vincenz and Elisabeth Hospital Mainz , Germany.

PMID: 27114808 PMCID: PMC4821226 DOI: 10.4081/or.2016.6162

Abstract

The aim of this study was to investigate the safety of injection of bone marrow aspirate concentrate during core decompression and to study its clinical (visual analogue scale; Harris-Hip-score) and radiological outcomes (magnetic resonance imaging). In this prospective and randomized clinical trial we evaluated 24 consecutive patients with non-traumatic femoral head necrosis (FHN) during a period of two years after intervention. In vitro analysis of mesenchymal stem cells was performed by evaluating the fibroblast colony forming units (CFU-Fs). Postoperatively, significant decrease in pain associated with a functional benefit lasting was observed. However, there was no difference in the clinical outcome between the two study groups. Over the period of two years there was no significant difference between the head survival rate between both groups. In contrast to that, we could not perceive any significant change in the volume of FHN in both treatment groups related to the longitudinal course after treating. The number of CFU showed a significant increase after centrifugation. This trial could not detect a benefit from the additional injection of bone marrow concentrate with regard to bone regeneration and clinical outcome in the short term.

Keywords: Femoral head necrosis; autologous bone marrow concentrate; core decompression; mesenchymal stem cells

References

  1. Arch Orthop Trauma Surg. 2000;120(5-6):241-4 - PubMed
  2. Clin Orthop Relat Res. 1996 Mar;(324):169-78 - PubMed
  3. Blood. 1980 Aug;56(2):289-301 - PubMed
  4. Clin Orthop Relat Res. 1997 Feb;(335):181-9 - PubMed
  5. Orthopade. 2000 May;29(5):389-402 - PubMed
  6. J Bone Joint Surg Am. 1995 Mar;77(3):459-74 - PubMed
  7. Bone. 2012 Jan;50(1):325-30 - PubMed
  8. Bone. 2011 Nov;49(5):1005-9 - PubMed
  9. J Arthroplasty. 2000 Feb;15(2):171-8 - PubMed
  10. Orthop Clin North Am. 2004 Jul;35(3):273-83, vii-viii - PubMed
  11. J Bone Joint Surg Br. 1985 Jan;67(1):3-9 - PubMed
  12. Clin Orthop Relat Res. 2002 Dec;(405):14-23 - PubMed
  13. J Bone Joint Surg Br. 1988 Jan;70(1):78-84 - PubMed
  14. J Bone Joint Surg Br. 1995 Nov;77(6):870-4 - PubMed
  15. Orthopade. 2000 May;29(5):420-9 - PubMed
  16. Bone Joint J. 2013 Nov;95-B(11 Suppl A):46-50 - PubMed
  17. Orthop Rev (Pavia). 2009 Oct 10;1(2):e32 - PubMed
  18. Curr Opin Rheumatol. 2004 Jul;16(4):443-9 - PubMed
  19. J Bone Joint Surg Br. 2005 Jul;87(7):896-902 - PubMed
  20. Eur Cell Mater. 2008 Oct 23;16:47-55 - PubMed
  21. Hip Int. 2012 Sep-Oct;22(5):489-93 - PubMed
  22. Expert Opin Biol Ther. 2005 Apr;5(4):437-42 - PubMed
  23. Instr Course Lect. 2003;52:337-55 - PubMed
  24. Int Orthop. 2012 Aug;36(8):1583-8 - PubMed

Publication Types