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Hussain S, Haroon J, Ejaz S, et al. Variants of resistin gene and the risk of idiopathic dilated cardiomyopathy in Pakistan. Meta Gene. 2016;9:37-41doi: 10.1016/j.mgene.2016.03.006.
Hussain, S., Haroon, J., Ejaz, S., & Javed, Q. (2016). Variants of resistin gene and the risk of idiopathic dilated cardiomyopathy in Pakistan. Meta gene, 937-41. https://doi.org/10.1016/j.mgene.2016.03.006
Hussain, Sabir, et al. "Variants of resistin gene and the risk of idiopathic dilated cardiomyopathy in Pakistan." Meta gene vol. 9 (2016): 37-41. doi: https://doi.org/10.1016/j.mgene.2016.03.006
Hussain S, Haroon J, Ejaz S, Javed Q. Variants of resistin gene and the risk of idiopathic dilated cardiomyopathy in Pakistan. Meta Gene. 2016 Mar 30;9:37-41. doi: 10.1016/j.mgene.2016.03.006. eCollection 2016 Sep. PMID: 27114921; PMCID: PMC4833058.
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Meta Gene. 2016 Mar 30;9:37-41. doi: 10.1016/j.mgene.2016.03.006. eCollection 2016 Sep.

Variants of resistin gene and the risk of idiopathic dilated cardiomyopathy in Pakistan.

Meta gene

Sabir Hussain, Javeria Haroon, Shagufta Ejaz, Qamar Javed

Affiliations

  1. Department of Biosciences, COMSATS Institute of Information Technology, Islamabad 45550, Pakistan.
  2. Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.
  3. Department of Cardiology, Federal Government Polyclinic Hospital, G-5, Islamabad, Pakistan.

PMID: 27114921 PMCID: PMC4833058 DOI: 10.1016/j.mgene.2016.03.006

Abstract

BACKGROUND: In cardiovascular disease phenotypes, a genetic factor is an important determinant of both familial and non-familial dilated cardiomyopathies. Resistin is a novel adipocyte derived peptide, associated with inflammation and suggested to be involved in contractile abnormalities of cardiomyocytes.

METHODS: In this study, we examined the association of the RETN SNPs in - 420 and + 299 in patients with idiopathic dilated cardiomyopathy (IDCM). Patients with IDCM (n = 250) and healthy controls (n = 250) were enrolled in this study. RETN genotyping was performed by using PCR-RFLP method.

RESULTS: RETN - 420C > G and + 299G > A polymorphisms were significantly more prevalent in patient group vs. controls (P < 0.0001 and P = 0.0007, respectively). GG genotype at - 420 and AA genotype at + 299 were higher in the patient group compared with healthy controls (OR = 11.4, P < 0.0001, and OR = 2.3, P = 0.030, respectively). We found that the - 420G allele increased the risk of developing IDCM in patients (P < 0.0001). Moreover, there was a significant difference between G and A alleles at RETN + 299 from IDCM cases and controls (P = 0.0032). The RETN - 420G and + 299A haplotypes were more prevalent in the patient vs. control group (P < 0.0001).

CONCLUSION: The results suggest that the RETN - 420C > G and + 299G > A polymorphisms may have a role in the pathogenesis of IDCM.

Keywords: Association; Idiopathic dilated cardiomyopathy; Pakistan; RETN gene; Single nucleotide polymorphism

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