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Horev L, Ramot Y, Klapholz L. Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric. Drug Saf Case Rep. 2015;2(1):4doi: 10.1007/s40800-015-0006-4.
Horev, L., Ramot, Y., & Klapholz, L. (2015). Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric. Drug safety - case reports, 2(1), 4. https://doi.org/10.1007/s40800-015-0006-4
Horev, Liran, et al. "Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric." Drug safety - case reports vol. 2,1 (2015): 4. doi: https://doi.org/10.1007/s40800-015-0006-4
Horev L, Ramot Y, Klapholz L. Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric. Drug Saf Case Rep. 2015 Dec;2(1):4. doi: 10.1007/s40800-015-0006-4. PMID: 27747716; PMCID: PMC5005595.
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Drug Saf Case Rep. 2015 Dec;2(1):4. doi: 10.1007/s40800-015-0006-4.

Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric.

Drug safety - case reports

Liran Horev, Yuval Ramot, Laurent Klapholz

Affiliations

  1. Department of Dermatology, Hadassah-Hebrew University Medical Center, PO Box 12000, 9112001, Jerusalem, Israel. [email protected].
  2. Department of Dermatology, Hadassah-Hebrew University Medical Center, PO Box 12000, 9112001, Jerusalem, Israel.

PMID: 27747716 PMCID: PMC5005595 DOI: 10.1007/s40800-015-0006-4

Abstract

Yellow discoloration of the skin may be caused by several etiologies, including jaundice, hypervitaminosis, drug reaction or chemical exposure. Herein we describe a 68-year-old woman with a history of breast and thyroid carcinoma, presenting with a yellow discoloration of her soles, after ingestion of one capsule a day of turmeric root extract (Bluebonnet Turmeric Root, 500 mg, Vcap), taken for its anti-cancer properties, for 4 months. After drug cessation, the yellow hue disappeared completely. A Naranjo assessment score of 5 was obtained, indicating a probable relationship between the patient's symptom and her use of the drug. Curcumin, a mixture of diferuloymethane derivatives known as curcuminoids, is a yellow pigment present in the spice turmeric. Topical application of curcumin to the human skin is joined by orange-yellow discoloration. To the best of our knowledge, yellow skin discoloration after oral intake of turmeric is not mentioned in the medical literature.

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