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Valinoti AC, da Costa LC, Farah A, et al. Are Pediatric Antibiotic Formulations Potentials Risk Factors for Dental Caries and Dental Erosion?. Open Dent J. 2016;10:420-30doi: 10.2174/1874210601610010420.
Valinoti, A. C., da Costa, L. C., Farah, A., Pereira de Sousa, V., Fonseca-Gonçalves, A., & Maia, L. C. (2016). Are Pediatric Antibiotic Formulations Potentials Risk Factors for Dental Caries and Dental Erosion?. The open dentistry journal, 10420-30. https://doi.org/10.2174/1874210601610010420
Valinoti, Ana Carolina, et al. "Are Pediatric Antibiotic Formulations Potentials Risk Factors for Dental Caries and Dental Erosion?." The open dentistry journal vol. 10 (2016): 420-30. doi: https://doi.org/10.2174/1874210601610010420
Valinoti AC, da Costa LC, Farah A, Pereira de Sousa V, Fonseca-Gonçalves A, Maia LC. Are Pediatric Antibiotic Formulations Potentials Risk Factors for Dental Caries and Dental Erosion?. Open Dent J. 2016 Aug 22;10:420-30. doi: 10.2174/1874210601610010420. eCollection 2016. PMID: 27583053; PMCID: PMC4995533.
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Open Dent J. 2016 Aug 22;10:420-30. doi: 10.2174/1874210601610010420. eCollection 2016.

Are Pediatric Antibiotic Formulations Potentials Risk Factors for Dental Caries and Dental Erosion?.

The open dentistry journal

Ana Carolina Valinoti, Luiz Carlos da Costa, Adriana Farah, Valéria Pereira de Sousa, Andréa Fonseca-Gonçalves, Lucianne Cople Maia

Affiliations

  1. Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, RJ,Brazil.
  2. Systems and Computing Engineering, COPPE/ Universidade Federal do Rio de Janeiro, RJ,Brazil.
  3. Institute of Nutrition, Universidade Federal do Rio de Janeiro, RJ,Brazil.
  4. Quality Control of Drugs and Medicines Laboratory, Department of Medicines, Universidade Federal do Rio de Janeiro, RJ,Brazil.

PMID: 27583053 PMCID: PMC4995533 DOI: 10.2174/1874210601610010420

Abstract

INTRODUCTION: One of the most frequent parents' concerns is that oral antibiotic formulations induce dental damage in their children's. This study aimed to assess the cariogenic and erosive potentials of 29 pediatric antibiotics.

MATERIALS AND METHODS: Replicates of each antibiotic were analyzed for the concentration of sugars (sucrose, glucose and fructose) and sorbitol by high performance liquid chromatography (HPLC). The pH was determined by digital pHmeter. Titratable acidity was determined in triplicate using the same pHmeter by gradual addition of 0.1N sodium hydroxide (NaOH) until pH 7.0. Viscosity measurements were carried out using a viscosimeter. In order to rank the relative performance of each medicine, the DEA (Data Envelopment Analysis) methodology was used.

RESULTS: Sucrose was present in most samples (n=24) with concentrations ranging from 26 to ≈ 100g% (w/w). Only one antibiotic contained sorbitol (66.9g%). Twenty seven antibiotics presented pH values ranging from 4.1 to 6.9 and most of them (n=15) showed the pH below the critical value for dissolution of hydroxyapatite. The values of titratable acidity and viscosity ranged from 0.26 to 40.48 ml and from 20 to 1780cP, respectively. DEA methodology showed that two medicines were distant from the performance frontier (Klaricid(®) 50mg and Zinnat(®) 250mg), which means that these medicines showed the worst performance and, therefore, greater potential for dissolution of dental enamel.

CONCLUSION: Many antibiotics presented high concentration of sugars, high titratable acidity, pH below the critical value and high viscosity which can be considered risk factors for dental caries and erosion, when consumed frequently.

Keywords: Antibiotics; Dental caries; Pharmaceutical preparations; Sweetening agents; Tooth erosion; Viscosity

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