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Miri-Aliabad G, Sadat-Hosseini M, Dorgalaleh A. Bilineal Acute Leukemia Associated With Fanconi Syndrome: The First Case Report. Iran J Pediatr. 2016;26(3):e3723doi: 10.5812/ijp.3723.
Miri-Aliabad, G., Sadat-Hosseini, M., & Dorgalaleh, A. (2016). Bilineal Acute Leukemia Associated With Fanconi Syndrome: The First Case Report. Iranian journal of pediatrics, 26(3), e3723. https://doi.org/10.5812/ijp.3723
Miri-Aliabad, Ghasem, et al. "Bilineal Acute Leukemia Associated With Fanconi Syndrome: The First Case Report." Iranian journal of pediatrics vol. 26,3 (2016): e3723. doi: https://doi.org/10.5812/ijp.3723
Miri-Aliabad G, Sadat-Hosseini M, Dorgalaleh A. Bilineal Acute Leukemia Associated With Fanconi Syndrome: The First Case Report. Iran J Pediatr. 2016 May 28;26(3):e3723. doi: 10.5812/ijp.3723. eCollection 2016 Jun. PMID: 27617066; PMCID: PMC4992150.
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Iran J Pediatr. 2016 May 28;26(3):e3723. doi: 10.5812/ijp.3723. eCollection 2016 Jun.

Bilineal Acute Leukemia Associated With Fanconi Syndrome: The First Case Report.

Iranian journal of pediatrics

Ghasem Miri-Aliabad, Maryam Sadat-Hosseini, Akbar Dorgalaleh

Affiliations

  1. Department of Pediatrics, Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran.
  2. Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
  3. Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, IR Iran.

PMID: 27617066 PMCID: PMC4992150 DOI: 10.5812/ijp.3723

Abstract

Fanconi syndrome is a metabolic disorder involving dysfunction of the renal proximal tubules, resulting in excessive urinary excretion of several metabolites. Various factors may lead to Fanconi syndrome, as it may be a genetic disease with primary or secondary etiologies, or may be acquired. In this study, we report a unique case of Fanconi syndrome with development of a relatively rare acute leukemia, a condition that has not been reported before. The case was an 8-year-old boy with familial occurrence of Fanconi syndrome, presenting with pallor, asthenia, recurrent infections, growth failure, and a variety of biochemical and hematological abnormalities. After physical examination, radiographic studies, and comprehensive laboratory analyses, Fanconi syndrome associated with bilineal acute leukemia, of myeloid and T-lymphoid lineages, was diagnosed.

Keywords: Bilineal Leukemia; Fanconi Syndrome; Renal Dysfunction

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