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Thomeer MG, Broker M, Verheij J, et al. Hepatocellular adenoma: when and how to treat? Update of current evidence. Therap Adv Gastroenterol. 2016;9(6):898-912doi: 10.1177/1756283X16663882.
Thomeer, M. G., Broker, M., Verheij, J., Doukas, M., Terkivatan, T., Bijdevaate, D., De Man, R. A., Moelker, A., & IJzermans, J. N. (2016). Hepatocellular adenoma: when and how to treat? Update of current evidence. Therapeutic advances in gastroenterology, 9(6), 898-912. https://doi.org/10.1177/1756283X16663882
Thomeer, Maarten G, et al. "Hepatocellular adenoma: when and how to treat? Update of current evidence." Therapeutic advances in gastroenterology vol. 9,6 (2016): 898-912. doi: https://doi.org/10.1177/1756283X16663882
Thomeer MG, Broker M, Verheij J, Doukas M, Terkivatan T, Bijdevaate D, De Man RA, Moelker A, IJzermans JN. Hepatocellular adenoma: when and how to treat? Update of current evidence. Therap Adv Gastroenterol. 2016 Nov;9(6):898-912. doi: 10.1177/1756283X16663882. Epub 2016 Sep 28. PMID: 27803743; PMCID: PMC5076773.
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Therap Adv Gastroenterol. 2016 Nov;9(6):898-912. doi: 10.1177/1756283X16663882. Epub 2016 Sep 28.

Hepatocellular adenoma: when and how to treat? Update of current evidence.

Therapeutic advances in gastroenterology

Maarten G Thomeer, Mirelle Broker, Joanne Verheij, Michael Doukas, Turkan Terkivatan, Diederick Bijdevaate, Robert A De Man, Adriaan Moelker, Jan N IJzermans

Affiliations

  1. Department of Radiology, Erasmus Medical Center Rotterdam, P.O Box 2040, 3015 CE Rotterdam, The Netherlands.
  2. Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  3. Department of Pathology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
  4. Department of pathology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  5. Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  6. Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

PMID: 27803743 PMCID: PMC5076773 DOI: 10.1177/1756283X16663882

Abstract

Hepatocellular adenoma (HCA) is a rare, benign liver tumor. Discovery of this tumor is usually as an incidental finding, correlated with the use of oral contraceptives, or pregnancy. Treatment options have focused on conservative management for the straightforward, smaller lesions (<5 cm), with resection preferred for larger lesions (>5 cm) that pose a greater risk of hemorrhage or malignant progression. In recent years, a new molecular subclassification of HCA has been proposed, associated with characteristic morphological features and loss or increased expression of immunohistochemical markers. This subclassification could possibly provide considerable benefits in terms of patient stratification, and the selection of treatment options. In this review we discuss the decision-making processes and associated risk analyses that should be made based on lesion size, and subtype. The usefulness of this subclassification system in terms of the procedures instigated as part of the diagnostic work-up of a suspected HCA will be outlined, and suitable treatment schemes proposed.

Keywords: MRI; adenoma; immunohistochemistry; liver

Conflict of interest statement

The authors declare that there is no conflict of interest.

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