Display options
Cite
Rafieian N, Abdolsamadi H, Moghadamnia A, et al. Efficacy of alum for treatment of recurrent aphthous stomatitis. Caspian J Intern Med. 2016;7(3):201-205
Rafieian, N., Abdolsamadi, H., Moghadamnia, A., Jazayeri, M., Seif-Rabiee, M., Salmanzadeh, M., & Radi, S. (2016). Efficacy of alum for treatment of recurrent aphthous stomatitis. Caspian journal of internal medicine, 7(3), 201-205.
Rafieian, Nasrin, et al. "Efficacy of alum for treatment of recurrent aphthous stomatitis." Caspian journal of internal medicine vol. 7,3 (2016): 201-205.
Rafieian N, Abdolsamadi H, Moghadamnia A, Jazayeri M, Seif-Rabiee M, Salmanzadeh M, Radi S. Efficacy of alum for treatment of recurrent aphthous stomatitis. Caspian J Intern Med. 2016;7(3):201-205. PMID: 27757206; PMCID: PMC5062179.
Copy Download .nbib Format: NLM
Share it on

Caspian J Intern Med. 2016;7(3):201-205.

Efficacy of alum for treatment of recurrent aphthous stomatitis.

Caspian journal of internal medicine

Nasrin Rafieian, Hamidreza Abdolsamadi, Aliakbar Moghadamnia, Mina Jazayeri, Mohammadali Seif-Rabiee, Mina Salmanzadeh, Shahrbanoo Radi

Affiliations

  1. Department of Oral Medicine, Faculty of Dentistry, Alborz University of Medical Sciences, Karaj, Iran.
  2. Dental Research Center and Center for Molecular Medicine, Faculty of Dentistry, Alborz University of Medical Sciences, Karaj, Iran.
  3. Department of Pharmacology, Babol University of Medical Sciences, Babol, Iran.
  4. Department of Social Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.
  5. Hamedan University of Medical Sciences, Hamedan, Iran.
  6. Faculty of Dentistry, Hamedan University of Medical Sciences, Hamedan, Iran.

PMID: 27757206 PMCID: PMC5062179

Abstract

BACKGROUND: Recurrent aphthous stomatitis (RAS) is the most common painful ulcers of oral mucosal which can cause many sufferings. Treatment of RAS often includes administration of corticosteroids, analgesics and regulators of the immune system. However, considering the side effects of these medications, even their topical application must be done with caution. Alum is used in traditional medicine for treatment of oral ulcers without significant side effect. This study sought to assess the effect of topical application of alum on aphthous ulcers.

METHODS: This clinical randomized double-blind placebo-controlled study was conducted on 50 females aged 21 to 27 years. Mucosal adhesive patches were prepared in two forms of basic and 7% alum-containing patches. Subjects in two groups of case and control randomly received the mucosal adhesive patches containing alum and the basic patches, respectively three times in five days. Duration of recovery, changes in size of lesion and severity of pain were recorded. Data were entered into SPSS Version 16 and analyzed using t-test.

RESULTS: The average period of full recovery was 7.52 days in the case and 12.2 days in the control groups; which was significantly different (p<0.001). Size of wound and severity of pain were significantly lower at one, three and five days posttreatment compared to baseline values before treatment in the case group (p<0.001) and the difference in this regard between the case and control groups was statistically significant.

CONCLUSION: Alum can significantly decrease the size of aphthous lesions, severity of pain and expedite the recovery of patients with RAS.

Keywords: Alum compounds; Aphthous; Stomatitis

References

  1. J Am Acad Dermatol. 1994 Sep;31(3 Pt 1):459-61 - PubMed
  2. Crit Rev Oral Biol Med. 1998;9(3):306-21 - PubMed
  3. Pediatr Dent. 1996 Mar-Apr;18(2):139-44 - PubMed
  4. J Clin Exp Dent. 2014 Apr 01;6(2):e168-74 - PubMed
  5. J Am Dent Assoc. 2012 Apr;143(4):370-6 - PubMed
  6. Clin Dermatol. 2000 Sep-Oct;18(5):569-78 - PubMed
  7. J Oral Sci. 2000 Mar;42(1):15-9 - PubMed
  8. Quintessence Int. 2000 Feb;31(2):95-112 - PubMed
  9. J Am Dent Assoc. 1992 Oct;123(10):83-6 - PubMed
  10. J Am Dent Assoc. 2003 Feb;134(2):200-7 - PubMed
  11. Oral Dis. 2006 Jan;12(1):1-21 - PubMed
  12. Am J Health Syst Pharm. 2001 Jan 1;58(1):41-50; quiz 51-3 - PubMed
  13. Am J Otolaryngol. 2000 Nov-Dec;21(6):389-93 - PubMed
  14. Antimicrob Agents Chemother. 1998 Oct;42(10):2492-4 - PubMed
  15. Phytother Res. 2009 Feb;23(2):246-50 - PubMed
  16. Community Dent Oral Epidemiol. 1973;1(1):37-40 - PubMed
  17. Br J Dermatol. 2005 Sep;153(3):521-5 - PubMed

Publication Types