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Tiong SS, Dickie C, Haas RL, et al. The role of radiotherapy in the management of localized soft tissue sarcomas. Cancer Biol Med. 2016;13(3):373-383doi: 10.20892/j.issn.2095-3941.2016.0028.
Tiong, S. S., Dickie, C., Haas, R. L., & O'Sullivan, B. (2016). The role of radiotherapy in the management of localized soft tissue sarcomas. Cancer biology & medicine, 13(3), 373-383. https://doi.org/10.20892/j.issn.2095-3941.2016.0028
Tiong, Siaw Sze, et al. "The role of radiotherapy in the management of localized soft tissue sarcomas." Cancer biology & medicine vol. 13,3 (2016): 373-383. doi: https://doi.org/10.20892/j.issn.2095-3941.2016.0028
Tiong SS, Dickie C, Haas RL, O'Sullivan B. The role of radiotherapy in the management of localized soft tissue sarcomas. Cancer Biol Med. 2016 Sep;13(3):373-383. doi: 10.20892/j.issn.2095-3941.2016.0028. PMID: 27807504; PMCID: PMC5069839.
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Cancer Biol Med. 2016 Sep;13(3):373-383. doi: 10.20892/j.issn.2095-3941.2016.0028.

The role of radiotherapy in the management of localized soft tissue sarcomas.

Cancer biology & medicine

Siaw Sze Tiong, Colleen Dickie, Rick L Haas, Brian O'Sullivan

Affiliations

  1. Department of Radiation Oncology, Princess Margaret Cancer Center, University of Toronto, Toronto M5G 2M9, ON, Canada.
  2. Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam 1066, CX, The Netherlands.

PMID: 27807504 PMCID: PMC5069839 DOI: 10.20892/j.issn.2095-3941.2016.0028

Abstract

The combination of radiotherapy (RT) and function-preserving surgery is the most usual contemporary approach in the management of soft tissue sarcomas (STS). Pre- and postoperative RT result in similar local control rates, as shown by a landmark trial in extremity STS. In this review, the role of RT in the management of extremity STS will be discussed, but STS in other sites, including retroperitoneal STS, will also be addressed. The focus will consider various aspects of RT including strategies to reduce the volume of tissue being irradiated, dose, scheduling, and the possible of omission of RT in selected cases. Finally, technology advances through the use of intensity-modulated radiotherapy (IMRT), image-guided IMRT, intraoperative radiotherapy (IORT) and particle therapy will also be discussed.

Keywords: Sarcoma; extremity sarcoma; radiotherapy; retroperitoneal sarcoma; surgery

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