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Chia SL, Leong DT. Reducing ZnO nanoparticles toxicity through silica coating. Heliyon. 2016;2(10):e00177doi: 10.1016/j.heliyon.2016.e00177.
Chia, S. L., & Leong, D. T. (2016). Reducing ZnO nanoparticles toxicity through silica coating. Heliyon, 2(10), e00177. https://doi.org/10.1016/j.heliyon.2016.e00177
Chia, Sing Ling, and Leong, David Tai. "Reducing ZnO nanoparticles toxicity through silica coating." Heliyon vol. 2,10 (2016): e00177. doi: https://doi.org/10.1016/j.heliyon.2016.e00177
Chia SL, Leong DT. Reducing ZnO nanoparticles toxicity through silica coating. Heliyon. 2016 Oct 21;2(10):e00177. doi: 10.1016/j.heliyon.2016.e00177. eCollection 2016 Oct. PMID: 27812550; PMCID: PMC5079660.
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Heliyon. 2016 Oct 21;2(10):e00177. doi: 10.1016/j.heliyon.2016.e00177. eCollection 2016 Oct.

Reducing ZnO nanoparticles toxicity through silica coating.

Heliyon

Sing Ling Chia, David Tai Leong

Affiliations

  1. Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore.

PMID: 27812550 PMCID: PMC5079660 DOI: 10.1016/j.heliyon.2016.e00177

Abstract

ZnO NPs have good antimicrobial activity that can be utilized as agents to prevent harmful microorganism growth in food. However, the use of ZnO NPs as food additive is limited by the perceived high toxicity of ZnO NPs in many earlier toxicity studies. In this study, surface modification by silica coating was used to reduce the toxicity of ZnO NPs by significantly reducing the dissolution of the core ZnO NPs. To more accurately recapitulate the scenario of ingested ZnO NPs, we tested our as synthesized ZnO NPs in ingestion fluids (synthetic saliva and synthetic gastric juice) to determine the possible forms of ZnO NPs in digestive system before exposing the products to colorectal cell lines. The results showed that silica coating is highly effective in reducing toxicity of ZnO NPs through prevention of the dissociation of ZnO NPs to zinc ions in both neutral and acidic condition. The silica coating however did not alter the desired antimicrobial activity of ZnO NPs to

Keywords: Inorganic chemistry; Materials science; Physical chemistry

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