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Sheng P, Cheng YL, Cai CC, et al. Clinicopathological Features and Immunohistochemical Alterations of Keratinocyte Proliferation, Melanocyte Density, Smooth Muscle Hyperplasia and Nerve Fiber Distribution in Becker's Nevus. Ann Dermatol. 2016;28(6):697-703doi: 10.5021/ad.2016.28.6.697.
Sheng, P., Cheng, Y. L., Cai, C. C., Guo, W. J., Zhou, Y., Shi, G., & Fan, Y. M. (2016). Clinicopathological Features and Immunohistochemical Alterations of Keratinocyte Proliferation, Melanocyte Density, Smooth Muscle Hyperplasia and Nerve Fiber Distribution in Becker's Nevus. Annals of dermatology, 28(6), 697-703. https://doi.org/10.5021/ad.2016.28.6.697
Sheng, Ping, et al. "Clinicopathological Features and Immunohistochemical Alterations of Keratinocyte Proliferation, Melanocyte Density, Smooth Muscle Hyperplasia and Nerve Fiber Distribution in Becker's Nevus." Annals of dermatology vol. 28,6 (2016): 697-703. doi: https://doi.org/10.5021/ad.2016.28.6.697
Sheng P, Cheng YL, Cai CC, Guo WJ, Zhou Y, Shi G, Fan YM. Clinicopathological Features and Immunohistochemical Alterations of Keratinocyte Proliferation, Melanocyte Density, Smooth Muscle Hyperplasia and Nerve Fiber Distribution in Becker's Nevus. Ann Dermatol. 2016 Dec;28(6):697-703. doi: 10.5021/ad.2016.28.6.697. Epub 2016 Nov 23. PMID: 27904268; PMCID: PMC5125950.
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Ann Dermatol. 2016 Dec;28(6):697-703. doi: 10.5021/ad.2016.28.6.697. Epub 2016 Nov 23.

Clinicopathological Features and Immunohistochemical Alterations of Keratinocyte Proliferation, Melanocyte Density, Smooth Muscle Hyperplasia and Nerve Fiber Distribution in Becker's Nevus.

Annals of dermatology

Ping Sheng, Yun-Long Cheng, Chuan-Chuan Cai, Wei-Jin Guo, Ying Zhou, Ge Shi, Yi-Ming Fan

Affiliations

  1. Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Guangdong, China.
  2. Department of Dermatology, Gaobu Hospital of Dongguan, Guangdong, China.

PMID: 27904268 PMCID: PMC5125950 DOI: 10.5021/ad.2016.28.6.697

Abstract

BACKGROUND: Although Becker's nevus (BN) is a relatively common disease, the systematic studies of clinicopathological and immunohistochemical results are poorly reported.

OBJECTIVE: To investigate the clinicopathological features and immunohistochemical alterations of keratinocyte proliferation, melanocyte density, smooth muscle hyperplasia and nerve fiber distribution in BN.

METHODS: Clinical and pathological data were collected in 60 newly-diagnosed BN cases. Immunohistochemical stain of Ki-67, Melan-A, keratin 15, smooth muscle actin and protein gene product 9.5 was performed in 21 cases.

RESULTS: The median diagnostic and onset age was 17 and 12 years, respectively. Skin lesions usually appeared on the upper trunk and upper limbs. The pathological features included the rete ridge elongation and fusion and basal hyperpigmentation. Epidermal Ki-67, Melan-A and keratin 15 expression and dermal nerve fiber length were significantly higher in lesional and perilesional skin than in normal skin (

CONCLUSION: Although the clinical diagnosis of BN is often straightforward, histopathology is helpful to differentiate from other pigmentary disorders. The hyperproliferation of keratinocytes, melanocytes, arrector pili muscle and dermal nerve fibers could be involved in the pathogenesis of BN.

Keywords: Becker's nevus; Keratinocytes; Keratins; Melanocytes

References

  1. Pediatr Dermatol. 2012 Sep-Oct;29(5):571-4 - PubMed
  2. J Dermatol. 2012 Aug;39(8):682-7 - PubMed
  3. J Cutan Pathol. 2008 Dec;35(12):1121-6 - PubMed
  4. Mod Pathol. 2011 Jan;24(1):90-7 - PubMed
  5. J Cutan Pathol. 2003 Jan;30(1):11-7 - PubMed
  6. Int J Trichology. 2014 Jul;6(3):88-94 - PubMed
  7. Br J Dermatol. 2011 Aug;165(2):277-84 - PubMed
  8. Int J Dermatol. 2005 Jan;44(1):20-4 - PubMed
  9. Cell. 2011 Feb 18;144(4):577-89 - PubMed
  10. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):323-7 - PubMed
  11. J Cutan Pathol. 1980 Dec;7(6):404-9 - PubMed
  12. ISRN Dermatol. 2014 Apr 30;2014:953747 - PubMed
  13. Ann Indian Acad Neurol. 2015 Jan-Mar;18(1):90-2 - PubMed
  14. J Drugs Dermatol. 2009 Aug;8(8):745-8 - PubMed
  15. Neurology. 2011 Jul 19;77(3):242-9 - PubMed
  16. Eur J Dermatol. 2008 Sep-Oct;18(5):518-23 - PubMed
  17. Br J Dermatol. 2005 Apr;152(4):632-8 - PubMed
  18. Am J Clin Dermatol. 2015 Jun;16(3):197-204 - PubMed
  19. J Am Acad Dermatol. 2008 Nov;59(5):834-8 - PubMed
  20. Clin Exp Dermatol. 2006 Nov;31(6):807-12 - PubMed
  21. Int J Dermatol. 2010 Jun;49(6):718-20 - PubMed
  22. Histol Histopathol. 2011 Jun;26(6):673-8 - PubMed

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