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Entenza JM, Giddey M, Vouillamoz J, et al. Assessment of the in vitro synergy of daptomycin plus linezolid against multidrug-resistant enterococci. J Glob Antimicrob Resist. 2014;2(4):306-308doi: 10.1016/j.jgar.2014.09.004.
Entenza, J. M., Giddey, M., Vouillamoz, J., Moreillon, P., & Mancini, S. (2014). Assessment of the in vitro synergy of daptomycin plus linezolid against multidrug-resistant enterococci. Journal of global antimicrobial resistance, 2(4), 306-308. https://doi.org/10.1016/j.jgar.2014.09.004
Entenza, José M, et al. "Assessment of the in vitro synergy of daptomycin plus linezolid against multidrug-resistant enterococci." Journal of global antimicrobial resistance vol. 2,4 (2014): 306-308. doi: https://doi.org/10.1016/j.jgar.2014.09.004
Entenza JM, Giddey M, Vouillamoz J, Moreillon P, Mancini S. Assessment of the in vitro synergy of daptomycin plus linezolid against multidrug-resistant enterococci. J Glob Antimicrob Resist. 2014 Dec;2(4):306-308. doi: 10.1016/j.jgar.2014.09.004. Epub 2014 Oct 02. PMID: 27873692.
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J Glob Antimicrob Resist. 2014 Dec;2(4):306-308. doi: 10.1016/j.jgar.2014.09.004. Epub 2014 Oct 02.

Assessment of the in vitro synergy of daptomycin plus linezolid against multidrug-resistant enterococci.

Journal of global antimicrobial resistance

José M Entenza, Marlyse Giddey, Jacques Vouillamoz, Philippe Moreillon, Stefano Mancini

Affiliations

  1. Department of Fundamental Microbiology, Biophore Building, University of Lausanne, CH-1015 Lausanne, Switzerland.
  2. Department of Fundamental Microbiology, Biophore Building, University of Lausanne, CH-1015 Lausanne, Switzerland. Electronic address: [email protected].

PMID: 27873692 DOI: 10.1016/j.jgar.2014.09.004

Abstract

The widespread incidence of enterococci resistant to ampicillin, vancomycin and aminoglycosides, the first-line anti-enterococcal antibiotics, has made the treatment of severe enterococcal infections difficult and alternatives should be explored. We investigated the activity of daptomycin combined with linezolid against three Enterococcus faecalis and four Enterococcus faecium strains resistant to standard drugs used for therapy. Minimum inhibitory concentrations (MICs) were determined by the broth dilution method. Drug interactions were assessed by the checkerboard and time-kill methods. Synergy was defined by a fractional inhibitory concentration index (FICI) of ≤0.5 or a ≥2log

Copyright © 2014 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.

Keywords: Daptomycin; Enterococcus faecalis; Enterococcus faecium; Linezolid; Synergy

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