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Front Physiol. 2016 Oct 21;7:479. doi: 10.3389/fphys.2016.00479. eCollection 2016.

Mitochondrial Quality Control in Cardiac Diseases.

Frontiers in physiology

Juliane C Campos, Luiz H M Bozi, Luiz R G Bechara, Vanessa M Lima, Julio C B Ferreira

Affiliations

  1. Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo, Brazil.

PMID: 27818636 PMCID: PMC5073139 DOI: 10.3389/fphys.2016.00479

Abstract

Disruption of mitochondrial homeostasis is a hallmark of cardiac diseases. Therefore, maintenance of mitochondrial integrity through different surveillance mechanisms is critical for cardiomyocyte survival. In this review, we discuss the most recent findings on the central role of mitochondrial quality control processes including regulation of mitochondrial redox balance, aldehyde metabolism, proteostasis, dynamics, and clearance in cardiac diseases, highlighting their potential as therapeutic targets.

Keywords: 4-hydroxynonenal; aldehyde dehydrogenase 2; bioenergetics; fusion-fission balance; mitochondrial unfolded protein response; mitophagy; oxidative stress

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