Display options
Cite
Milani-Nejad N, Schultz EJ, Slabaugh JL, et al. Myocardial Contractile Dysfunction Is Present without Histopathology in a Mouse Model of Limb-Girdle Muscular Dystrophy-2F and Is Prevented after Claudin-5 Virotherapy. Front Physiol. 2016;7:539doi: 10.3389/fphys.2016.00539.
Milani-Nejad, N., Schultz, E. J., Slabaugh, J. L., Janssen, P. M., & Rafael-Fortney, J. A. (2016). Myocardial Contractile Dysfunction Is Present without Histopathology in a Mouse Model of Limb-Girdle Muscular Dystrophy-2F and Is Prevented after Claudin-5 Virotherapy. Frontiers in physiology, 7539. https://doi.org/10.3389/fphys.2016.00539
Milani-Nejad, Nima, et al. "Myocardial Contractile Dysfunction Is Present without Histopathology in a Mouse Model of Limb-Girdle Muscular Dystrophy-2F and Is Prevented after Claudin-5 Virotherapy." Frontiers in physiology vol. 7 (2016): 539. doi: https://doi.org/10.3389/fphys.2016.00539
Milani-Nejad N, Schultz EJ, Slabaugh JL, Janssen PM, Rafael-Fortney JA. Myocardial Contractile Dysfunction Is Present without Histopathology in a Mouse Model of Limb-Girdle Muscular Dystrophy-2F and Is Prevented after Claudin-5 Virotherapy. Front Physiol. 2016 Dec 06;7:539. doi: 10.3389/fphys.2016.00539. eCollection 2016. PMID: 27999547; PMCID: PMC5138189.
Copy Download .nbib Format: NLM
Share it on

Front Physiol. 2016 Dec 06;7:539. doi: 10.3389/fphys.2016.00539. eCollection 2016.

Myocardial Contractile Dysfunction Is Present without Histopathology in a Mouse Model of Limb-Girdle Muscular Dystrophy-2F and Is Prevented after Claudin-5 Virotherapy.

Frontiers in physiology

Nima Milani-Nejad, Eric J Schultz, Jessica L Slabaugh, Paul M L Janssen, Jill A Rafael-Fortney

Affiliations

  1. Department of Physiology and Cell Biology, The Ohio State University Wexner Medical CenterColumbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical CenterColumbus, OH, USA; Medical Scientist Training Program and Biomedical Sciences Graduate Program, The Ohio State University Wexner Medical CenterColumbus, OH, USA.
  2. Department of Physiology and Cell Biology, The Ohio State University Wexner Medical CenterColumbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical CenterColumbus, OH, USA; Department of Molecular and Cellular Biochemistry, The Ohio State University Wexner Medical CenterColumbus, OH, USA.
  3. Department of Physiology and Cell Biology, The Ohio State University Wexner Medical CenterColumbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical CenterColumbus, OH, USA.

PMID: 27999547 PMCID: PMC5138189 DOI: 10.3389/fphys.2016.00539

Abstract

Mutations in several members of the dystrophin glycoprotein complex lead to skeletal and cardiomyopathies. Cardiac care for these muscular dystrophies consists of management of symptoms with standard heart medications after detection of reduced whole heart function. Recent evidence from both Duchenne muscular dystrophy patients and animal models suggests that myocardial dysfunction is present before myocardial damage or deficiencies in whole heart function, and that treatment prior to heart failure symptoms may be beneficial. To determine whether this same early myocardial dysfunction is present in other muscular dystrophy cardiomyopathies, we conducted a physiological assessment of cardiac function at the tissue level in the δ-sarcoglycan null mouse model (

Keywords: cardiac contractile force; claudin-5; heart; muscular dystrophy; sarcoglycan

References

  1. Cell. 1999 Aug 20;98(4):465-74 - PubMed
  2. J Cell Biol. 1999 Oct 4;147(1):185-94 - PubMed
  3. J Cell Sci. 2000 Jul;113 ( Pt 14):2535-44 - PubMed
  4. J Cell Biol. 2003 May 12;161(3):459-60 - PubMed
  5. Neuromuscul Disord. 2003 May;13(4):294-302 - PubMed
  6. Muscle Nerve. 2004 Mar;29(3):409-19 - PubMed
  7. Nat Med. 2004 Aug;10(8):828-34 - PubMed
  8. Mol Ther. 2004 Oct;10(4):671-8 - PubMed
  9. Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2373-8 - PubMed
  10. Pflugers Arch. 2006 Feb;451(5):625-30 - PubMed
  11. Am J Physiol. 1992 Jul;263(1 Pt 2):H293-306 - PubMed
  12. Nat Med. 2006 Jul;12(7):787-9 - PubMed
  13. Trends Cardiovasc Med. 2007 Feb;17(2):55-9 - PubMed
  14. Mol Ther. 2007 Jun;15(6):1086-92 - PubMed
  15. Am Heart J. 2007 Sep;154(3):596-602 - PubMed
  16. J Mol Cell Cardiol. 2007 Nov;43(5):523-31 - PubMed
  17. J Comp Physiol B. 2008 Mar;178(3):307-13 - PubMed
  18. Cardiovasc Res. 2008 Sep 1;79(4):652-61 - PubMed
  19. J Mol Cell Cardiol. 2008 Jul;45(1):81-7 - PubMed
  20. Mol Ther. 2008 Sep;16(9):1539-45 - PubMed
  21. Cardiovasc Res. 2009 Jun 1;82(3):404-10 - PubMed
  22. J Am Coll Cardiol. 2009 Apr 7;53(14):1204-10 - PubMed
  23. Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1092-9 - PubMed
  24. Eur J Heart Fail. 2010 Nov;12(11):1163-70 - PubMed
  25. Neuromuscul Disord. 2011 Jan;21(1):68-73 - PubMed
  26. Physiol Genomics. 2011 Jan 7;43(1):24-31 - PubMed
  27. J Appl Physiol (1985). 2011 Feb;110(2):512-9 - PubMed
  28. Circ Cardiovasc Imaging. 2011 Jan;4(1):67-76 - PubMed
  29. J Transl Med. 2011 May 17;9:68 - PubMed
  30. FASEB J. 2011 Sep;25(9):3106-14 - PubMed
  31. Circulation. 2011 Aug 2;124(5):582-8 - PubMed
  32. Skelet Muscle. 2011 Mar 17;1(1):13 - PubMed
  33. Mol Ther. 2012 Jul;20(7):1378-83 - PubMed
  34. J Gen Physiol. 2013 Jan;141(1):133-9 - PubMed
  35. J Cardiovasc Magn Reson. 2013 Jan 16;15:4 - PubMed
  36. PLoS One. 2013;8(2):e57260 - PubMed
  37. Ann Neurol. 2013 Apr;73(4):481-8 - PubMed
  38. Physiol Genomics. 2013 Jul 15;45(14):597-605 - PubMed
  39. Clin Sci (Lond). 2014 Jul;127(2):101-9 - PubMed
  40. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6004-9 - PubMed
  41. J Muscle Res Cell Motil. 2014 Aug;35(3-4):225-34 - PubMed
  42. Sci Transl Med. 2014 Oct 22;6(259):259ra144 - PubMed
  43. Cardiovasc Pathol. 2015 May-Jun;24(3):160-167 - PubMed
  44. Biophys Rev. 2014 Dec;6(3-4):273-289 - PubMed
  45. J Cell Biol. 1993 Aug;122(4):809-23 - PubMed
  46. J Cell Biol. 1997 Oct 20;139(2):375-85 - PubMed
  47. J Med Genet. 1997 Dec;34(12):973-7 - PubMed
  48. Curr Opin Neurol. 1998 Oct;11(5):443-52 - PubMed
  49. J Biol Chem. 1998 Dec 25;273(52):34667-70 - PubMed

Publication Types