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Lawton ZE, Traub A, Fatigante WL, et al. Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening. J Am Soc Mass Spectrom. 2016;28(6):1048-1059doi: 10.1007/s13361-016-1562-2.
Lawton, Z. E., Traub, A., Fatigante, W. L., Mancias, J., O'Leary, A. E., Hall, S. E., Wieland, J. R., Oberacher, H., Gizzi, M. C., & Mulligan, C. C. (2017). Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening. Journal of the American Society for Mass Spectrometry, 28(6), 1048-1059. https://doi.org/10.1007/s13361-016-1562-2
Lawton, Zachary E, et al. "Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening." Journal of the American Society for Mass Spectrometry vol. 28,6 (2017): 1048-1059. doi: https://doi.org/10.1007/s13361-016-1562-2
Lawton ZE, Traub A, Fatigante WL, Mancias J, O'Leary AE, Hall SE, Wieland JR, Oberacher H, Gizzi MC, Mulligan CC. Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening. J Am Soc Mass Spectrom. 2017 Jun;28(6):1048-1059. doi: 10.1007/s13361-016-1562-2. Epub 2016 Dec 20. PMID: 28000107.
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J Am Soc Mass Spectrom. 2017 Jun;28(6):1048-1059. doi: 10.1007/s13361-016-1562-2. Epub 2016 Dec 20.

Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening.

Journal of the American Society for Mass Spectrometry

Zachary E Lawton, Angelica Traub, William L Fatigante, Jose Mancias, Adam E O'Leary, Seth E Hall, Jamie R Wieland, Herbert Oberacher, Michael C Gizzi, Christopher C Mulligan

Affiliations

  1. Department of Chemistry, Illinois State University, Normal, IL, 61790, USA.
  2. Department of Management and Quantitative Methods, Illinois State University, Normal, IL, 61790, USA.
  3. Institute of Legal Medicine and Core Facility Metabolomics, Innsbruck Medical University, Innsbruck, Austria.
  4. Department of Criminal Justice Sciences, Illinois State University, Normal, IL, 61790, USA.
  5. Department of Chemistry, Illinois State University, Normal, IL, 61790, USA. [email protected].

PMID: 28000107 DOI: 10.1007/s13361-016-1562-2

Abstract

Forensic evidentiary backlogs are indicative of the growing need for cost-effective, high-throughput instrumental methods. One such emerging technology that shows high promise in meeting this demand while also allowing on-site forensic investigation is portable mass spectrometric (MS) instrumentation, particularly that which enables the coupling to ambient ionization techniques. While the benefits of rapid, on-site screening of contraband can be anticipated, the inherent legal implications of field-collected data necessitates that the analytical performance of technology employed be commensurate with accepted techniques. To this end, comprehensive analytical validation studies are required before broad incorporation by forensic practitioners can be considered, and are the focus of this work. Pertinent performance characteristics such as throughput, selectivity, accuracy/precision, method robustness, and ruggedness have been investigated. Reliability in the form of false positive/negative response rates is also assessed, examining the effect of variables such as user training and experience level. To provide flexibility toward broad chemical evidence analysis, a suite of rapidly-interchangeable ion sources has been developed and characterized through the analysis of common illicit chemicals and emerging threats like substituted phenethylamines. Graphical Abstract ᅟ.

Keywords: Ambient ionization; Analytical validation; Atmospheric pressure chemical ionization; Desorption electrospray ionization; Forensic evidence; Forensics; Paper spray ionization; Portable mass spectrometer; SWGDRUG

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