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Ingrosso G, Carosi A, di Cristino D, et al. Volumetric image-guided highly conformal radiotherapy of the prostate bed: Toxicity analysis. Rep Pract Oncol Radiother. 2016;22(1):64-70doi: 10.1016/j.rpor.2016.10.006.
Ingrosso, G., Carosi, A., di Cristino, D., Ponti, E., Lancia, A., Murgia, A., Bruni, C., Morelli, P., Pietrasanta, F., & Santoni, R. (2017). Volumetric image-guided highly conformal radiotherapy of the prostate bed: Toxicity analysis. Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology, 22(1), 64-70. https://doi.org/10.1016/j.rpor.2016.10.006
Ingrosso, Gianluca, et al. "Volumetric image-guided highly conformal radiotherapy of the prostate bed: Toxicity analysis." Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology vol. 22,1 (2017): 64-70. doi: https://doi.org/10.1016/j.rpor.2016.10.006
Ingrosso G, Carosi A, di Cristino D, Ponti E, Lancia A, Murgia A, Bruni C, Morelli P, Pietrasanta F, Santoni R. Volumetric image-guided highly conformal radiotherapy of the prostate bed: Toxicity analysis. Rep Pract Oncol Radiother. 2017 Jan-Feb;22(1):64-70. doi: 10.1016/j.rpor.2016.10.006. Epub 2016 Nov 24. PMID: 27920610; PMCID: PMC5126144.
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Rep Pract Oncol Radiother. 2017 Jan-Feb;22(1):64-70. doi: 10.1016/j.rpor.2016.10.006. Epub 2016 Nov 24.

Volumetric image-guided highly conformal radiotherapy of the prostate bed: Toxicity analysis.

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

Gianluca Ingrosso, Alessandra Carosi, Daniela di Cristino, Elisabetta Ponti, Andrea Lancia, Alessandra Murgia, Claudia Bruni, Pasquale Morelli, Franca Pietrasanta, Riccardo Santoni

Affiliations

  1. Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, Tor Vergata General Hospital, Rome, Italy.

PMID: 27920610 PMCID: PMC5126144 DOI: 10.1016/j.rpor.2016.10.006

Abstract

AIM: To evaluate toxicity of high conformal image-guided radiotherapy of the prostate bed.

BACKGROUND: Radiotherapy of the prostate bed has a pivotal role in the post-operative and salvage settings, but few clinical data are available on the use of daily image guidance in combination with highly conformal techniques, and data on long-term results are lacking.

MATERIALS AND METHODS: We analyzed 118 patients irradiated on the prostate bed using conformal plans processed with a micro-multileaf collimator, and daily checking treatment set-up with a cone-beam CT system. Correlation between toxicity and clinical-dosimetric parameters was assessed by the Cox regression model and log-rank test. Survival analyses were performed with the Kaplan-Meier method.

RESULTS: Median follow-up was 54.08 months. Late grade ≥2 gastro-intestinal (GI) and genito-urinary (GU) toxicity were 3.4% and 4.2%, respectively. Actuarial 4-year late grade ≥2 GI and GU toxicities were 4% and 6%, respectively. Four-year relapse-free survival was 87%. At log-rank test, acute grade ≥2 GI toxicity is associated with the use of antihypertensives (

CONCLUSIONS: Conformal volumetric image-guided radiotherapy of the prostate bed leads to low toxicity rates.

Keywords: Conformal radiotherapy; Image-guided radiotherapy; Prostate bed; Toxicity

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