Clin Cases Miner Bone Metab. 2016 May-Aug;13(2):123-126. doi: 10.11138/ccmbm/2016.13.2.123. Epub 2016 Oct 05.
Risk factors of mortality during the first year after low energy osteoporosis fracture: a retrospective case-control study.
Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases
Aurore Lloret, Guillaume Coiffier, Tiffen Couchouron, Aleth Perdriger, Pascal Guggenbuhl
Affiliations
Affiliations
- Service de Rhumatologie, CHU de Rennes Hôpital Sud, Rennes, Cedex 2, France.
- Service de Rhumatologie, CHU de Rennes Hôpital Sud, Rennes, Cedex 2, France; INSERM UMR 991, Rennes, France.
PMID: 27920808
PMCID: PMC5119709 DOI: 10.11138/ccmbm/2016.13.2.123
Abstract
INTRODUCTION: Osteoporotic fractures are a major public health problem because of the morbidity and mortality of fracture complications. The objective of this study was to examine predictive factors of mortality during the first year after an osteoporotic fracture.
METHODS: It is a retrospective case-control study using data of a group of 1081 patients aged over 50 years with severe osteoporotic fractures by the Rennes university hospital emergency department from August 2007 to September 2008. Patients (cases) who died during the year following the fracture were compared with others who had survived (controls) one year after the fracture, matched on age, sex and type of fracture. Pre-fracture comorbidities and complications after the fractures were studied.
RESULTS: Forty-two cases and 126 controls were analyzed without significant differences in age, sex or type of fracture. On univariate analysis, previous neoplasia, neurodegenerative disease, walking aids, thromboembolic complication, post fracture infection, post fracture heart failure, post fracture acute respiratory failure were associated with more mortality after osteoporotic fracture. After multivariate analysis, only previous neoplasia (OR = 4.63 [1.79 - 11.95]; p = 0.02) and acute respiratory failure after fracture (OR = 28.15 [5.75 - 137.9]; p<0.001) were retained as predictive factors during the year following the fracture.
CONCLUSION: Patients died more often from their co-morbidities than direct complications of their fractures. Osteoporotic fracture seems to be a marker of poor health status and a factor which may hasten the death.
Keywords: comorbidities; epidemiology; fracture; mortality; osteoporosis
Conflict of interest statement
All Authors declare no conflict of interest.
References
- Clin Orthop Relat Res. 2013 Sep;471(9):2846-51 - PubMed
- Bone. 2003 May;32(5):468-73 - PubMed
- Ann Intern Med. 2010 Mar 16;152(6):380-90 - PubMed
- Lancet. 1999 Mar 13;353(9156):878-82 - PubMed
- Osteoporos Int. 2000;11(3):228-32 - PubMed
- QJM. 2005 Jul;98(7):467-84 - PubMed
- Bone. 2011 Sep;49(3):553-8 - PubMed
- Ann Epidemiol. 2007 Jul;17(7):514-9 - PubMed
- Osteoporos Int. 2003 Jul;14(7):589-94 - PubMed
- Neth J Med. 1992 Aug;41(1-2):4-10 - PubMed
- J Chronic Dis. 1987;40(5):373-83 - PubMed
- Osteoporos Int. 2012 Dec;23(12):2797-803 - PubMed
- Osteoporos Int. 2009 Feb;20(2):221-9 - PubMed
- Osteoporos Int. 2000;11(7):556-61 - PubMed
- JAMA. 2009 Oct 14;302(14):1573-9 - PubMed
- J Clin Endocrinol Metab. 2010 Mar;95(3):1174-81 - PubMed
- J Am Geriatr Soc. 2000 Mar;48(3):283-8 - PubMed
- J Bone Miner Res. 2005 Mar;20(3):494-500 - PubMed
- Am J Epidemiol. 2010 Oct 15;172(8):942-51 - PubMed
- Med Klin (Munich). 2003 Aug 15;98(8):437-46 - PubMed
- J Clin Endocrinol Metab. 2014 Feb;99(2):415-23 - PubMed
- Osteoporos Int. 2009 Oct;20(10):1633-50 - PubMed
- J Bone Joint Surg Br. 2008 Apr;90(4):480-3 - PubMed
- Osteoporos Int. 2004 Nov;15(11):897-902 - PubMed
- Bone. 2013 Sep;56(1):23-9 - PubMed
- Osteoporos Int. 2011 Sep;22(9):2439-48 - PubMed
- Age Ageing. 2010 Mar;39(2):203-9 - PubMed
- PLoS One. 2013 Oct 29;8(10):e78169 - PubMed
- Calcif Tissue Int. 2005 Apr;76(4):235-42 - PubMed
- Clin Orthop Relat Res. 2004 Dec;(429):43-8 - PubMed
- Ann Pharmacother. 2002 Jan;36(1):17-23 - PubMed
- BMJ. 2005 Dec 10;331(7529):1374 - PubMed
- Osteoporos Int. 2005 Dec;16(12):1583-90 - PubMed
- N Engl J Med. 2007 Nov 1;357(18):1799-809 - PubMed
Publication Types