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Petrovic D, Estoppey Younes S, Pruijm M, et al. Relation of 24-hour urinary caffeine and caffeine metabolite excretions with self-reported consumption of coffee and other caffeinated beverages in the general population. Nutr Metab (Lond). 2016;13:81doi: 10.1186/s12986-016-0144-4.
Petrovic, D., Estoppey Younes, S., Pruijm, M., Ponte, B., Ackermann, D., Ehret, G., Ansermot, N., Mohaupt, M., Paccaud, F., Vogt, B., Pechère-Bertschi, A., Martin, P. Y., Burnier, M., Eap, C. B., Bochud, M., & Guessous, I. (2016). Relation of 24-hour urinary caffeine and caffeine metabolite excretions with self-reported consumption of coffee and other caffeinated beverages in the general population. Nutrition & metabolism, 1381. https://doi.org/10.1186/s12986-016-0144-4
Petrovic, Dusan, et al. "Relation of 24-hour urinary caffeine and caffeine metabolite excretions with self-reported consumption of coffee and other caffeinated beverages in the general population." Nutrition & metabolism vol. 13 (2016): 81. doi: https://doi.org/10.1186/s12986-016-0144-4
Petrovic D, Estoppey Younes S, Pruijm M, Ponte B, Ackermann D, Ehret G, Ansermot N, Mohaupt M, Paccaud F, Vogt B, Pechère-Bertschi A, Martin PY, Burnier M, Eap CB, Bochud M, Guessous I. Relation of 24-hour urinary caffeine and caffeine metabolite excretions with self-reported consumption of coffee and other caffeinated beverages in the general population. Nutr Metab (Lond). 2016 Nov 17;13:81. doi: 10.1186/s12986-016-0144-4. eCollection 2016. PMID: 27891166; PMCID: PMC5112879.
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Nutr Metab (Lond). 2016 Nov 17;13:81. doi: 10.1186/s12986-016-0144-4. eCollection 2016.

Relation of 24-hour urinary caffeine and caffeine metabolite excretions with self-reported consumption of coffee and other caffeinated beverages in the general population.

Nutrition & metabolism

Dusan Petrovic, Sandrine Estoppey Younes, Menno Pruijm, Belén Ponte, Daniel Ackermann, Georg Ehret, Nicolas Ansermot, Markus Mohaupt, Fred Paccaud, Bruno Vogt, Antoinette Pechère-Bertschi, Pierre-Yves Martin, Michel Burnier, Chin B Eap, Murielle Bochud, Idris Guessous

Affiliations

  1. Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la corniche 10, Lausanne, 1010 Switzerland.
  2. Department of Nephrology and Hypertension, Lausanne University Hospital, Rue du Bugnon 17, Lausanne, 1011 Switzerland.
  3. Department of Nephrology and Hypertension, University Hospital of Geneva (HUG), Rue Gabrielle Perret-Gentil 4, Geneva, 1205 Switzerland.
  4. University Clinic for Nephrology, Hypertension and Clinical Pharmacology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 15, Bern, 3010 Switzerland.
  5. Department of Cardiology, University Hospital of Geneva (HUG), Rue Gabrielle Perret-Gentil 4, Geneva, 1205 Switzerland.
  6. Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, 1008 Switzerland.
  7. Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, 1008 Switzerland ; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland.
  8. Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la corniche 10, Lausanne, 1010 Switzerland ; Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine and Primary Care and Emergency Medicine, University Hospital of Geneva (HUG), Rue Gabrielle Perret-Gentil 4, Geneva, 1205 Switzerland ; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, USA ; Lausanne University Outpatient Clinic, Rue du Bugnon 44, Lausanne, 1011 Switzerland ; Unit of Population Epidemiology, University Hospital of Geneva (HUG), Rue Gabrielle Perret-Gentil 4, Geneva, 1205 Switzerland.

PMID: 27891166 PMCID: PMC5112879 DOI: 10.1186/s12986-016-0144-4

Abstract

BACKGROUND: Caffeine intake is generally estimated by self-reported consumption, but it remains unclear how well self-report associates with metabolite urinary excretion. We investigated the associations of self-reported consumption of caffeinated drinks with urinary excretion of caffeine and its major metabolites in an adult population.

METHODS: We used data from the population-based Swiss Kidney Project on Genes in Hypertension (SKIPOGH) study. Consumption of caffeinated coffee, decaffeinated coffee and other caffeinated beverages was assessed by self-administered questionnaire. Quantification of caffeine, paraxanthine, theobromine and theophylline was performed by ultra-high performance liquid chromatography tandem mass spectrometry in 24-h urine. Association of reported consumption of caffeinated drinks with urinary caffeine derived metabolites was determined by quantile regression. We then explored the association between urinary metabolite excretion and dichotomized weekly consumption frequency of caffeinated coffee, with Receiver Operator Characteristic (ROC) analysis.

RESULTS: In the present analysis, we included 598 individuals (52% women, mean age =46 ± 17 years). Self-reported caffeinated coffee intake was positively associated with 24-h urinary excretions of paraxanthine, theophylline and caffeine (

CONCLUSION: Our results suggest that reported consumption of caffeinated coffee is positively associated with 24-h urinary excretion of caffeine, paraxanthine, and theophylline, and may be used as a marker of caffeine intake for epidemiological studies.

Keywords: Caffeine; Paraxanthine; Population-based; Questionnaire; Theophylline; Urinary excretion

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