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Zamanian Azodi M, Peyvandi H, Rostami-Nejad M, et al. Protein-protein interaction network of celiac disease. Gastroenterol Hepatol Bed Bench. 2016;9(4):268-277
Zamanian Azodi, M., Peyvandi, H., Rostami-Nejad, M., Safaei, A., Rostami, K., Vafaee, R., Heidari, M., Hosseini, M., & Zali, M. R. (2016). Protein-protein interaction network of celiac disease. Gastroenterology and hepatology from bed to bench, 9(4), 268-277.
Zamanian Azodi, Mona, et al. "Protein-protein interaction network of celiac disease." Gastroenterology and hepatology from bed to bench vol. 9,4 (2016): 268-277.
Zamanian Azodi M, Peyvandi H, Rostami-Nejad M, Safaei A, Rostami K, Vafaee R, Heidari M, Hosseini M, Zali MR. Protein-protein interaction network of celiac disease. Gastroenterol Hepatol Bed Bench. 2016;9(4):268-277. PMID: 27895852; PMCID: PMC5118851.
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Gastroenterol Hepatol Bed Bench. 2016;9(4):268-277.

Protein-protein interaction network of celiac disease.

Gastroenterology and hepatology from bed to bench

Mona Zamanian Azodi, Hassan Peyvandi, Mohammad Rostami-Nejad, Akram Safaei, Kamran Rostami, Reza Vafaee, Mohammadhossein Heidari, Mostafa Hosseini, Mohammad Reza Zali

Affiliations

  1. Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  2. Hearing Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  3. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  4. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  5. Department of Gastroenterology, Milton Keynes University Hospital United Kingdom.
  6. Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

PMID: 27895852 PMCID: PMC5118851

Abstract

AIM: The aim of this study is to investigate the Protein-Protein Interaction Network of Celiac Disease.

BACKGROUND: Celiac disease (CD) is an autoimmune disease with susceptibility of individuals to gluten of wheat, rye and barley

MATERIAL AND METHODS: In the present study, we collected the articles that focused on the proteomic data in celiac disease. According to the gene expression investigations of these articles, 31 candidate proteins were selected for this study. The networks of related differentially expressed protein were explored using Cytoscape 3.3 and the PPI analysis methods such as MCODE and ClueGO.

RESULTS: According to the network analysis Ubiquitin C, Heat shock protein 90kDa alpha (cytosolic and Grp94); class A, B and 1 member, Heat shock 70kDa protein, and protein 5 (glucose-regulated protein, 78kDa), T-complex, Chaperon in containing TCP1; subunit 7 (beta) and subunit 4 (delta) and subunit 2 (beta), have been introduced as hub-bottlnecks proteins. HSP90AA1, MKKS, EZR, HSPA14, APOB and CAD have been determined as seed proteins.

CONCLUSION: Chaperons have a bold presentation in curtail area in network therefore these key proteins beside the other hub-bottlneck proteins may be a suitable candidates biomarker panel for diagnosis, prognosis and treatment processes in celiac disease.

Keywords: Network; Protein-protein interaction; celiac disease; hub-bottleneck

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