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Atmanli A, Domian IJ. Recreating the Cardiac Microenvironment in Pluripotent Stem Cell Models of Human Physiology and Disease. Trends Cell Biol. 2016;27(5):352-364doi: 10.1016/j.tcb.2016.11.010.
Atmanli, A., & Domian, I. J. (2017). Recreating the Cardiac Microenvironment in Pluripotent Stem Cell Models of Human Physiology and Disease. Trends in cell biology, 27(5), 352-364. https://doi.org/10.1016/j.tcb.2016.11.010
Atmanli, Ayhan, and Domian, Ibrahim John. "Recreating the Cardiac Microenvironment in Pluripotent Stem Cell Models of Human Physiology and Disease." Trends in cell biology vol. 27,5 (2017): 352-364. doi: https://doi.org/10.1016/j.tcb.2016.11.010
Atmanli A, Domian IJ. Recreating the Cardiac Microenvironment in Pluripotent Stem Cell Models of Human Physiology and Disease. Trends Cell Biol. 2017 May;27(5):352-364. doi: 10.1016/j.tcb.2016.11.010. Epub 2016 Dec 19. PMID: 28007424; PMCID: PMC5403626.
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Trends Cell Biol. 2017 May;27(5):352-364. doi: 10.1016/j.tcb.2016.11.010. Epub 2016 Dec 19.

Recreating the Cardiac Microenvironment in Pluripotent Stem Cell Models of Human Physiology and Disease.

Trends in cell biology

Ayhan Atmanli, Ibrahim John Domian

Affiliations

  1. Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Biomedical Engineering, Tufts University, Medford, MA, USA.
  2. Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA. Electronic address: [email protected].

PMID: 28007424 PMCID: PMC5403626 DOI: 10.1016/j.tcb.2016.11.010

Abstract

The advent of human pluripotent stem cell (hPSC) biology has opened unprecedented opportunities for the use of tissue engineering to generate human cardiac tissue for in vitro study. Engineering cardiac constructs that recapitulate human development and disease requires faithful recreation of the cardiac niche in vitro. Here we discuss recent progress in translating the in vivo cardiac microenvironment into PSC models of the human heart. We review three key physiologic features required to recreate the cardiac niche and facilitate normal cardiac differentiation and maturation: the biochemical, biophysical, and bioelectrical signaling cues. Finally, we discuss key barriers that must be overcome to fulfill the promise of stem cell biology in preclinical applications and ultimately in clinical practice.

Copyright © 2016 Elsevier Ltd. All rights reserved.

Keywords: cardiac myocytes; cardiac niche; cellular microenvironment; disease modeling; pluripotent stem cells; tissue engineering

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