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Sci Rep. 2016 Nov 29;6:38038. doi: 10.1038/srep38038.

The Association between Smoking and Epiretinal Membrane.

Scientific reports

Sheng-Zhan Wang, Qi-Hu Tong, Hui-Yun Wang, Qin-Kang Lu, Yu-Feng Xu

Affiliations

  1. Ningbo Optometry &Ophthalmology Center, the Affiliated Eye Hospital of Wenzhou Medical College, Ningbo Yinzhou people's Hospital, Ningbo, Zhejiang, 315040, China.
  2. Department of Ophthalmology, the Second Affiliated Hospital of Zhejiang University, College of Medicine, Jiefang Road 88, Hangzhou, Zhejiang, 310009, China.

PMID: 27897264 PMCID: PMC5126679 DOI: 10.1038/srep38038

Abstract

We conducted a meta-analysis of analytic and observational studies to evaluate the association between smoking and epiretinal membrane (ERM). The pertinent studies were identified via a literature search using three databases (MEDLINE, Cochrane Library, Embase) and the reference lists of retrieved studies. Cohort, case-control and cross-sectional studies meeting the predefined criteria were included. We extracted the odds ratios (OR) and 95% confidence intervals (CI) from each study. Overall risk estimates were pooled using random-effects models. Subgroup analyses based on several stratified factors were also performed. Two cohort studies and six cross-sectional studies involving 46,837 subjects were included. The pooled effect of all eight studies showed an unexpected significant decreased association between smoking and the occurrence of ERM (OR, 0.72; 95% CI 0.61-0.84; pā€‰=ā€‰0.29, I

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