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Yildirim A, Aydin A, Demir T, et al. Echocardiographic Follow-Up of Patent Foramen Ovale and the Factors Affecting Spontaneous Closure. Acta Cardiol Sin. 2016;32(6):731-737doi: 10.6515/acs20160205a.
Yildirim, A., Aydin, A., Demir, T., Aydin, F., Ucar, B., & Kilic, Z. (2016). Echocardiographic Follow-Up of Patent Foramen Ovale and the Factors Affecting Spontaneous Closure. Acta Cardiologica Sinica, 32(6), 731-737. https://doi.org/10.6515/acs20160205a
Yildirim, Ali, et al. "Echocardiographic Follow-Up of Patent Foramen Ovale and the Factors Affecting Spontaneous Closure." Acta Cardiologica Sinica vol. 32,6 (2016): 731-737. doi: https://doi.org/10.6515/acs20160205a
Yildirim A, Aydin A, Demir T, Aydin F, Ucar B, Kilic Z. Echocardiographic Follow-Up of Patent Foramen Ovale and the Factors Affecting Spontaneous Closure. Acta Cardiol Sin. 2016 Nov;32(6):731-737. doi: 10.6515/acs20160205a. PMID: 27899861; PMCID: PMC5126452.
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Acta Cardiol Sin. 2016 Nov;32(6):731-737. doi: 10.6515/acs20160205a.

Echocardiographic Follow-Up of Patent Foramen Ovale and the Factors Affecting Spontaneous Closure.

Acta Cardiologica Sinica

Ali Yildirim, Alperen Aydin, Tevfik Demir, Fatma Aydin, Birsen Ucar, Zubeyir Kilic

Affiliations

  1. Department of Pediatric.
  2. Department of Pediatric Cardiology, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.

PMID: 27899861 PMCID: PMC5126452 DOI: 10.6515/acs20160205a

Abstract

BACKGROUND: The aim of the present study was to evaluate the echocardiographic follow-up of patent foramen ovale, which is considered a potential etiological factor in various diseases, and to determine the factors affecting spontaneous closure.

METHODS: Between January 2000 and June 2012, records of 918 patients with patent foramen ovale were retrospectively reviewed. Patency of less than 3 mm around the fossa ovalis is called patent foramen ovale. Patients with cyanotic congenital heart diseases, severe heart valve disorders and severe hemodynamic left to right shunts were excluded from the study. The patients were divided into three groups based on age; 1 day-1 month in group 1, 1 month-12 months in group 2, and more than 12 months in group 3.

RESULTS: Of the 918 patients, 564 (61.4%) had spontaneous closure, 328 (35.8%) had patent foramen ovale continued, 15 (1.6%) patients had patent foramen ovale enlarged to 3-5 mm, 6 patients were enlarged to 5-8 mm, and in one patient patent foramen ovale reached to more than 8 mm size. Defect was spontaneously closed in 65.9% of the patients in group 1, 66.7% of the patients in group 2, and 52.3% of the patients in group 3. There was a negative correlation between the age of diagnosis and spontaneous closure (p < 0.05). Gender, prematurity and coexisting malformations such as patent ductus arteriosus and atrial septal aneurysm did not have any effect on spontaneous closure of patent foramen ovale (p > 0.05). However, ventricular septal defect and spontaneous closure of patent foramen ovale had a positive correlation (p < 0.01). No correlation was noted between the existence of atrial septal aneurysm, prematurity, and maturity of the patients.

CONCLUSIONS: The present study demonstrated that spontaneous closure rate of patent foramen ovale is high. Furthermore, a positive correlation was found between spontaneous closure of patent foramen ovale with early diagnosis and small defect size.

Keywords: Echocardiography; Patent foramen ovale; Spontaneus closure

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