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Wang PF, Song SY, Guo H, et al. Prognostic role of pretreatment red blood cell distribution width in patients with cancer: A meta-analysis of 49 studies. J Cancer. 2019;10(18):4305-4317doi: 10.7150/jca.31598.
Wang, P. F., Song, S. Y., Guo, H., Wang, T. J., Liu, N., & Yan, C. X. (2019). Prognostic role of pretreatment red blood cell distribution width in patients with cancer: A meta-analysis of 49 studies. Journal of Cancer, 10(18), 4305-4317. https://doi.org/10.7150/jca.31598
Wang, Peng-Fei, et al. "Prognostic role of pretreatment red blood cell distribution width in patients with cancer: A meta-analysis of 49 studies." Journal of Cancer vol. 10,18 (2019): 4305-4317. doi: https://doi.org/10.7150/jca.31598
Wang PF, Song SY, Guo H, Wang TJ, Liu N, Yan CX. Prognostic role of pretreatment red blood cell distribution width in patients with cancer: A meta-analysis of 49 studies. J Cancer. 2019 Jul 10;10(18):4305-4317. doi: 10.7150/jca.31598. eCollection 2019. PMID: 31413750; PMCID: PMC6691718.
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J Cancer. 2019 Jul 10;10(18):4305-4317. doi: 10.7150/jca.31598. eCollection 2019.

Prognostic role of pretreatment red blood cell distribution width in patients with cancer: A meta-analysis of 49 studies.

Journal of Cancer

Peng-Fei Wang, Si-Ying Song, Hang Guo, Ting-Jian Wang, Ning Liu, Chang-Xiang Yan

Affiliations

  1. Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
  2. School of Basic Medical Sciences, Capital Medical University, Beijing, China.
  3. Department of Orthopedics, Shanghai Pudong New Area Gongli Hospital, Naval Military Medical University, Shanghai, China.

PMID: 31413750 PMCID: PMC6691718 DOI: 10.7150/jca.31598

Abstract

Red blood cell distribution width (RDW) has been recently demonstrated to be a predictor of inflammation. High pretreatment RDW level is associated with poor survival outcomes in various malignancies, although the results are controversial. We aimed to investigate the prognostic role of RDW. A systematic literature search was performed in MEDLINE and EMBASE till April 2018. Pooled hazard ratios (HRs) were estimated for overall survival (OS) and combined disease-free survival, progression-free survival, and recurrence-free survival (DFS/PFS/RFS). 49 studies with 19,790 individuals were included in the final analysis. High RDW level adversely affected both OS and DFS/PFS/RFS. For solid cancers, colorectal cancer (CRC) had the strongest relationship with poor OS, followed by hepatic cancer (HCC). Negative OS outcomes were also observed in hematological malignancies. Furthermore, patients at either early or advanced stage had inverse relationship between high pretreatment RDW and poor OS. Studies with cut-off values between 13% and 14% had worse HRs for OS and DFS/PFS/RFS than others. Furthermore, region under the curve (ROC) analysis was used widely to define cut-off values and had relatively closer relationship with poorer HRs. In conclusion, our results suggested that elevated pretreatment RDW level could be a negative predictor for cancer prognosis.

Keywords: malignancies; meta-analysis; prognosis; red blood cell distribution width

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

References

  1. Biometrics. 2000 Jun;56(2):455-63 - PubMed
  2. BMJ. 2001 Jul 28;323(7306):224-8 - PubMed
  3. Anticancer Drugs. 2003 Feb;14(2):119-23 - PubMed
  4. BMJ. 2003 Sep 6;327(7414):557-60 - PubMed
  5. Blood. 1992 Apr 15;79(8):1987-94 - PubMed
  6. J Clin Invest. 2004 May;113(9):1271-6 - PubMed
  7. Blood. 2004 Oct 15;104(8):2565-73 - PubMed
  8. Nat Clin Pract Gastroenterol Hepatol. 2004 Nov;1(1):39-45 - PubMed
  9. Am J Med. 2005 Nov;118(11):1288 - PubMed
  10. Ann Intern Med. 2006 Mar 21;144(6):427-37 - PubMed
  11. J Am Coll Cardiol. 2007 Jul 3;50(1):40-7 - PubMed
  12. Blood. 1991 Nov 15;78(10):2564-7 - PubMed
  13. Arch Intern Med. 2009 Mar 23;169(6):588-94 - PubMed
  14. Ann Oncol. 2010 Jul;21(7):1523-8 - PubMed
  15. Cell. 2010 Mar 19;140(6):883-99 - PubMed
  16. Clin Nutr. 2010 Oct;29(5):600-4 - PubMed
  17. Cell. 2011 Mar 4;144(5):646-74 - PubMed
  18. Dig Dis Sci. 2012 Apr;57(4):1033-8 - PubMed
  19. Cytokine. 2012 May;58(2):193-8 - PubMed
  20. Tumori. 2011 Nov-Dec;97(6):711-6 - PubMed
  21. Hepatology. 2012 Oct;56(4):1567-74 - PubMed
  22. Clin Chem Lab Med. 2011 Dec 17;50(4):635-41 - PubMed
  23. Eur J Cardiothorac Surg. 2014 Jan;45(1):108-13 - PubMed
  24. Clin Cancer Res. 2013 Dec 15;19(24):6678-85 - PubMed
  25. PLoS One. 2013 Nov 11;8(11):e80240 - PubMed
  26. Clin Chem Lab Med. 2014 Jul;52(7):1025-32 - PubMed
  27. J Int Med Res. 2014 Apr;42(2):554-65 - PubMed
  28. N Engl J Med. 2014 Apr 3;370(14):1298-306 - PubMed
  29. Clin Chem Lab Med. 2014 Sep;52(9):e197-9 - PubMed
  30. Biomed Res Int. 2014;2014:145619 - PubMed
  31. N Engl J Med. 2014 Jun 26;370(26):2539-40 - PubMed
  32. Clin Chem Lab Med. 2015 Feb;53(2):e25-8 - PubMed
  33. Onco Targets Ther. 2014 Sep 26;7:1743-52 - PubMed
  34. PLoS One. 2014 Oct 27;9(10):e111440 - PubMed
  35. Cancer Causes Control. 2015 Jan;26(1):45-56 - PubMed
  36. Crit Rev Clin Lab Sci. 2015;52(2):86-105 - PubMed
  37. Dis Markers. 2014;2014:860419 - PubMed
  38. Dig Liver Dis. 2015 Jun;47(6):488-94 - PubMed
  39. Lung Cancer. 2015 Jun;88(3):319-24 - PubMed
  40. J Thorac Oncol. 2015 Aug;10(8):1213-20 - PubMed
  41. Ann Surg Oncol. 2016 Jan;23(1):343-51 - PubMed
  42. Croat Med J. 2015 Aug;56(4):334-43 - PubMed
  43. Anticancer Res. 2015 Oct;35(10):5473-8 - PubMed
  44. Clin Chem Lab Med. 2015 Nov;53(12):2015-9 - PubMed
  45. Mediators Inflamm. 2015;2015:854670 - PubMed
  46. Clin Chim Acta. 2016 Jan 15;452:199-203 - PubMed
  47. Tumour Biol. 2016 Jul;37(7):9323-31 - PubMed
  48. Eur J Cancer. 2016 Mar;56:101-106 - PubMed
  49. Nat Immunol. 2016 Mar;17(3):230-40 - PubMed
  50. Cancer Biomark. 2016 Mar 4;16(4):507-12 - PubMed
  51. Medicine (Baltimore). 2016 Apr;95(17):e3430 - PubMed
  52. Oncotarget. 2016 May 31;7(22):32846-53 - PubMed
  53. Int J Clin Oncol. 2016 Oct;21(5):909-919 - PubMed
  54. Oncotarget. 2016 Jul 5;7(27):42650-42660 - PubMed
  55. Contemp Oncol (Pozn). 2016;20(2):153-7 - PubMed
  56. Eur Arch Otorhinolaryngol. 2017 Jan;274(1):535-542 - PubMed
  57. Onco Targets Ther. 2016 Oct 11;9:6111-6117 - PubMed
  58. Cancer Biomark. 2017;18(1):19-25 - PubMed
  59. Clin Chim Acta. 2017 Oct;473:198-203 - PubMed
  60. Oncotarget. 2017 Apr 4;8(14):23841-23850 - PubMed
  61. Int J Cancer. 2017 Mar 1;140(5):1068-1081 - PubMed
  62. Oncotarget. 2017 Feb 28;8(9):16027-16035 - PubMed
  63. Oncotarget. 2017 Jan 3;8(1):303-314 - PubMed
  64. QJM. 2017 Jun 1;110(6):361-367 - PubMed
  65. J Thorac Dis. 2016 Dec;8(12):3658-3666 - PubMed
  66. Oncotarget. 2017 Apr 4;8(14):22854-22862 - PubMed
  67. Oncotarget. 2017 May 30;8(22):36161-36170 - PubMed
  68. Sci Rep. 2017 Feb 22;7:43001 - PubMed
  69. Oncotarget. 2017 Jun 20;8(25):40724-40731 - PubMed
  70. Oncotarget. 2017 May 9;8(19):32309-32321 - PubMed
  71. Sci Rep. 2017 Jun 2;7(1):2709 - PubMed
  72. Ann Clin Lab Sci. 2017 May;47(3):282-290 - PubMed
  73. Med Sci Monit. 2017 Jul 01;23:3217-3223 - PubMed
  74. Cancer Biomark. 2017 Sep 7;20(3):267-272 - PubMed
  75. Eur Arch Otorhinolaryngol. 2017 Nov;274(11):3985-3992 - PubMed
  76. Medicine (Baltimore). 2017 Sep;96(39):e8056 - PubMed
  77. Oncotarget. 2017 Sep 30;8(54):92522-92535 - PubMed
  78. J Neurooncol. 2018 Apr;137(2):279-287 - PubMed
  79. BMC Gastroenterol. 2017 Dec 20;17(1):163 - PubMed
  80. Oncotarget. 2017 Nov 25;8(65):109468-109477 - PubMed
  81. Clin Genitourin Cancer. 2018 Jun;16(3):e677-e683 - PubMed
  82. J Ovarian Res. 2018 Jan 22;11(1):10 - PubMed
  83. Clin Chim Acta. 2018 Apr;479:98-102 - PubMed
  84. Oncol Lett. 2018 Mar;15(3):3339-3349 - PubMed
  85. Clin Chim Acta. 2018 Jun;481:34-41 - PubMed
  86. Medicine (Baltimore). 2018 Jan;97(3):e9641 - PubMed
  87. Oncotarget. 2018 Jan 10;9(11):10118-10127 - PubMed
  88. Am J Otolaryngol. 2018 Jul - Aug;39(4):453-458 - PubMed
  89. Biometrics. 1994 Dec;50(4):1088-101 - PubMed
  90. Blood. 1975 Jan;45(1):55-65 - PubMed
  91. J Clin Invest. 1993 Feb;91(2):416-9 - PubMed
  92. BMJ. 1998 Feb 7;316(7129):469; author reply 470-1 - PubMed
  93. Stat Med. 1998 Dec 30;17(24):2815-34 - PubMed

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