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Oncoimmunology. 2019 May 01;8(8):1608106. doi: 10.1080/2162402X.2019.1608106. eCollection 2019.

Exposure to the antimicrobial peptide LL-37 produces dendritic cells optimized for immunotherapy.

Oncoimmunology

Emily Gwyer Findlay, Andrew J Currie, Ailiang Zhang, Jana Ovciarikova, Lisa Young, Holly Stevens, Brian J McHugh, Marta Canel, Mohini Gray, Simon W F Milling, John D M Campbell, John Savill, Alan Serrels, Donald J Davidson

Affiliations

  1. University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.
  2. School of Veterinary and Life Sciences, Murdoch University, Perth, Western Australia, Australia.
  3. Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
  4. Scottish National Blood Transfusion Service, Heriot Watt Research Park, Edinburgh, UK.

PMID: 31413918 PMCID: PMC6682359 DOI: 10.1080/2162402X.2019.1608106

Abstract

Immunization of patients with autologous,

Keywords: CD103; CD141; CD86; CLEC9A; Immunotherapy; PD1; cancer; cathelicidin; cross-presentation; dendritic cells; host defense peptide

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